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Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma.
Stefan Antonowicz, Zsolt Bodai, Tom Wiggins, Sheraz R Markar, Piers R Boshier, Yan Mei Goh, Mina E Adam, Haonan Lu, Hiromi Kudo, Francesca Rosini, Robert Goldin, Daniela Moralli, Catherine M Green, Chris J Peters, Nagy Habib, Hani Gabra, Rebecca C Fitzgerald, Zoltan Takats, George B Hanna
Apr 16, 2021
Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients' breath and could improve early diagnosis, however the mechanisms of their production are unknown. Here, we show that weak aldehyde detoxification...
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Sally E Thomas, Elke Malzer, Adriana Ordóñez, Lucy E Dalton, Emily FA van T Wout, Elizabeth Liniker, Damian C Crowther, David A Lomas, Stefan J Marciniak
Feb 12, 2019
Cell cycle checkpoints ensure that proliferation occurs only under permissive conditions, but their role in linking nutrient availability to cell division is incompletely understood. Protein folding within the endoplasmic...
Animals Cell Cycle Cell Line Cell Line Tumor Cell Proliferation Cell Separation Drosophila melanogaster Endoplasmic Reticulum Flow Cytometry Gene Expression Regulation Genes p53 HEK293 Cells HeLa Cells Humans Plasmids Protein Biosynthesis Protein Phosphatase 1 RNA Interference Tumor Suppressor Protein p53
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.
Caroline Baynes, Catherine S Healey, Karen A Pooley, Serena Scollen, Robert N Luben, Deborah J Thompson, Paul DP Pharoah, Douglas F Easton, Bruce AJ Ponder, Alison M Dunning, SEARCH breast cancer study
Jun 17, 2011
Adult Aged Ataxia Telangiectasia Mutated Proteins Breast Neoplasms Cell Cycle Proteins Checkpoint Kinase 2 DNA-Binding Proteins Female Genes BRCA1 Genes BRCA2 Genes p53 Genetic Predisposition to Disease Haplotypes Humans Middle Aged Polymorphism Single Nucleotide Protein Serine-Threonine Kinases risk Tumor Suppressor Proteins
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Florian T Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier, Robert E Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A McCarroll, Kevin Eggan
May 01, 2017
Alleles Cell Count Cell Differentiation Cell Division Cell Line DNA DNA Mutational Analysis Exome Genes Dominant Genes p53 Human Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Loss of Heterozygosity Mosaicism Mutation Neoplasms Protein Domains selection Genetic Tumor Suppressor Protein p53
Sporadic implementation of UK familial mammographic surveillance guidelines 15 years after original publication.
D Gareth Evans, Maria Edwards, Stephen W Duffy, Cancer Genetics Group clinical leads, Marc Tischkowitz
Oct 10, 2019
Adult Breast Neoplasms Early Detection of Cancer Female Genes BRCA1 Genes BRCA2 Genes p53 Guideline Adherence Health Services Accessibility Heterozygote Humans Magnetic Resonance Imaging Mammography Medical History Taking Middle Aged Mutation Practice Guidelines as Topic Risk Assessment State Medicine United Kingdom
Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma.
NA Wong, L Brett, M Stewart, A Leitch, DB Longley, MG Dunlop, PG Johnston, AM Lessells, DI Jodrell
Sep 02, 2020
Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is inhibited by metabolites of the chemotherapeutic agent 5-fluorouracil (5FU). Nuclear expression of TS in human tissue in vivo has not been characterised and its...
Adenocarcinoma Adult Aged Antimetabolites Antineoplastic Cell Differentiation Cell Nucleus Colorectal Neoplasms Drug Resistance Neoplasm Enzyme Induction Enzyme Inhibitors Female Fluorouracil Gene Expression Profiling Genes p53 Humans Ki-67 Antigen Male Middle Aged Neoplasm Metastasis Neoplasm Proteins RNA Messenger RNA Neoplasm Reproducibility of Results Survival Analysis thymidylate synthase Treatment Outcome Tumor Suppressor Protein p53
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim, Christoph Ziegenhain, Julia Hess, Oliver M Dovey, Stefan Eser, Swati Parekh, Fernando Constantino-Casas, Jorge de la Rosa, Marta I Sierra, Mario Fraga, Julia Mayerle, Günter Klöppel, Juan Cadiñanos, Pentao Liu, George Vassiliou, Wilko Weichert, Katja Steiger, Wolfgang Enard, Roland M Schmid, Fengtang Yang, Kristian Unger, Günter Schneider, Ignacio Varela, Allan Bradley, Dieter Saur, Roland Rad
Jun 25, 2018
Adaptor Proteins Signal Transducing Alleles Animals Carcinogenesis Carcinoma Pancreatic Ductal Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p16 Disease Progression evolution Molecular Female Gene Dosage Genes myc Genes p53 Humans Male Mice Mutation NF-kappa B p52 Subunit Neoplasm Metastasis Nuclear Proteins Pancreatic Neoplasms Phenotype Phosphoproteins Proto-Oncogene Proteins p21(ras) Transcription Factors Transcriptome Transforming Growth Factor beta1 YAP-Signaling Proteins
Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients.
Marjanka K Schmidt, Johanna Tommiska, Annegien Broeks, Flora E van Leeuwen, Laura J Van't Veer, Paul DP Pharoah, Douglas F Easton, Mitul Shah, Manjeet Humphreys, Thilo Dörk, Scarlett A Reincke, Rainer Fagerholm, Carl Blomqvist, Heli Nevanlinna
Jun 17, 2011
p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.
Ivano Amelio, Mara Mancini, Varvara Petrova, Rob A Cairns, Polina Vikhreva, Sara Nicolai, Alberto Marini, Alexey A Antonov, John Le Quesne, Juvenal D Baena Acevedo, Kate Dudek, Gabriella Sozzi, Ugo Pastorino, Richard A Knight, Tak W Mak, Gerry Melino
Dec 04, 2018
HIF SWI/SNF Chromatin architecture microenvironment p53 Animals Carcinoma Non-Small-Cell Lung Cell Hypoxia Cell Line Tumor Extracellular Matrix Genes p53 Heterografts Humans Hypoxia-Inducible Factor 1 Lung Neoplasms Mice Mice Inbred BALB C Mice Nude Mutation Transcriptional Activation Tumor Microenvironment Tumor Suppressor Protein p53
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.
Jillian L Barlow, Lesley F Drynan, Duncan R Hewett, Luke R Holmes, Silvia Lorenzo-Abalde, Alison L Lane, Helen E Jolin, Richard Pannell, Angela J Middleton, See Heng Wong, Alan J Warren, James S Wainscoat, Jacqueline Boultwood, Andrew NJ McKenzie
Jan 29, 2020
The identification of the genes associated with chromosomal translocation breakpoints has fundamentally changed understanding of the molecular basis of hematological malignancies. By contrast, the study of chromosomal deletions...
Interaction between the Cockayne syndrome B and p53 proteins
The CSB protein plays a role in the transcription coupled repair (TCR) branch of the nucleotide excision repair pathway. CSB is very often found mutated in Cockayne syndrome, a segmental progeroid genetic disease characterized...