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How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors...

Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Calcium Signaling Carrier Proteins Feeding Behavior Interneurons Quinine Receptors AMPA Sensory Receptor Cells Sensory Thresholds

Behavioural imprinting IMM learning Memory Animals Chickens Imprinting Psychological Memory Mice Neurons Prosencephalon Proto-Oncogene Proteins c-fos Receptors AMPA Signal Transduction Synapses gamma-Aminobutyric Acid

A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external sphincters, with corresponding preservation of motor neurons in the brainstem oculomotor nuclei...

Aged Amyotrophic Lateral Sclerosis Female Gene Expression Regulation Genetic Predisposition to Disease Humans Male Middle Aged Motor Neurons Nerve Degeneration Receptors AMPA Spinal Cord Synaptic Transmission gamma-Aminobutyric Acid

Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response to agonist binding. Most studies have focused on the agonist-bound, activated channel while assigning a lesser role to the apo or...

X-ray crystallography Alternative Splicing Atomic force microscopy channel gating Electrophysiology Ion channel ionotropic glutamate receptor Patch clamp protein conformations synapse Allosteric Regulation Allosteric Site Alternative Splicing Animals cerebellum Cryoelectron Microscopy Crystallography X-Ray HEK293 Cells Humans Ion Channel Gating Membrane Proteins Mice Microscopy Atomic Force Patch-Clamp Techniques Protein Domains Protein Isoforms Protein Structure Quaternary Protein Structure Tertiary Purkinje Cells Receptors AMPA

AMPA receptor (AMPAR) abundance and positioning at excitatory synapses regulates the strength of transmission. Changes in AMPAR localisation can enact synaptic plasticity, allowing long-term information storage, and is therefore...

Amino Acid Sequence Animals CA1 Region Hippocampal Fluorescent Dyes Imaging Three-Dimensional Mice Inbred C57BL Models Neurological Mutation Neuronal Plasticity Neurons Nuclear Proteins Protein Binding Protein Domains Protein Multimerization Receptors AMPA Synapses Synaptic Transmission

AMPA-type glutamate receptors (AMPARs) mediate rapid signal transmission at excitatory synapses in the brain. Glutamate binding to the receptor's ligand-binding domains (LBDs) leads to ion channel activation and desensitization....

Animals Calcium Channels Cryoelectron Microscopy Glutamic Acid HEK293 Cells Humans Mutation Patch-Clamp Techniques Protein Domains Rats Receptors AMPA Recombinant Proteins Synaptic Transmission Transfection

AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout the brain. Their signalling is uniquely diversified by brain region-specific auxiliary subunits, providing an opportunity for the development of...

Calcium Channels Receptors AMPA Ligands Synaptic Transmission

Receptors AMPA Ligands Calcium Channels Synaptic Transmission

Animals Electric Stimulation Hippocampus long-term potentiation Male Neuronal Plasticity Neurons Phosphorylation Rats Rats Wistar Receptors AMPA Receptors N-Methyl-D-Aspartate Synaptic Transmission Thiazepines Time Factors