Search
Results: 59
3D complex
Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data...
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
Monica C Pillon, Meredith N Frazier, Lucas B Dillard, Jason G Williams, Seda Kocaman, Juno M Krahn, Lalith Perera, Cassandra K Hayne, Jacob Gordon, Zachary D Stewart, Mack Sobhany, Leesa J Deterding, Allen L Hsu, Venkata P Dandey, Mario J Borgnia, Robin E Stanley
Jan 27, 2021
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric...
Efficient and exact sampling of transition path ensembles on Markovian networks.
The problem of flickering trajectories in standard kinetic Monte Carlo (kMC) simulations prohibits sampling of the transition path ensembles (TPEs) on Markovian networks representing many slow dynamical processes of interest. In...
30+ year evolution of Cu in the surface sediment of Lake Poyang, China.
Poyang Lake, the largest freshwater lake in China, is increasingly experiencing Cu crises. Combining field data, laboratory experiments, and long-term simulations, we retrieved 30 + year evolution of Cu in surface sediments...
Light-triggered syneresis of a water insoluble peptide-hydrogel effectively removes small molecule waste contaminants.
A short peptide based hydrogel exhibits aqueous insolubility, thixotropy and efficient light induced syneresis. Upon irradiation with UV light, the hydrogel shrinks and expells ∼50% of the solvent. Syneresis is caused by...
Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
Benzhydryl Compounds Binding Sites Breast Neoplasms Catalase Cytochrome P-450 CYP1A2 Databases Chemical Databases Protein Dioxins Endocrine Disruptors Environmental Pollutants Female Humans Molecular Dynamics Simulation Phenols Protein Binding Protein Structure Tertiary Recombinant Proteins Sex Hormone-Binding Globulin
Application of Probabilistic Risk Assessment in Establishing Perchlorate and Goitrogen Risk Mitigation Strategies.
Douglas Crawford-Brown
Sep 02, 2015
aggregate risk cumulative risk goitrogens perchlorate probabilistic risk assessment regulatory rationality Adolescent Adult Antithyroid Agents Child Child Preschool Female Goiter Humans Infant Male Monte Carlo Method No-Observed-Adverse-Effect Level Perchlorates Pregnancy Probability Risk Assessment Threshold Limit Values Water Pollutants Chemical Water Supply Young Adult
Anthropogenic stressors impact fish sensory development and survival via thyroid disruption.
Marc Besson, William E Feeney, Isadora Moniz, Loïc François, Rohan M Brooker, Guillaume Holzer, Marc Metian, Natacha Roux, Vincent Laudet, David Lecchini
Jul 28, 2021
Physical descriptions of the bacterial nucleoid at large scales, and their biological implications.
Vincenzo G Benza, Bruno Bassetti, Kevin D Dorfman, Vittore F Scolari, Krystyna Bromek, Pietro Cicuta, Marco Cosentino Lagomarsino
May 25, 2018
Recent experimental and theoretical approaches have attempted to quantify the physical organization (compaction and geometry) of the bacterial chromosome with its complement of proteins (the nucleoid). The genomic DNA exists in...
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical investigation for the treatment of SCLC. As well as acting as a neuropeptide...
Acetylcysteine Animals Antineoplastic Agents Antineoplastic Agents Phytogenic Apoptosis CHO Cells Carcinoma Small Cell Cell Division Cricetinae Drug Synergism Etoposide Free Radical Scavengers Glutathione Growth Inhibitors JNK Mitogen-Activated Protein Kinases Lipid Peroxidation Lung Neoplasms MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases Oligopeptides Oxidation-Reduction Reactive Oxygen Species Stimulation Chemical Transcription Factor AP-1 Transcription Genetic Tumor Cells Cultured
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.
The deposition of pathological protein aggregates in the brain plays a central role in cognitive decline and structural damage associated with neurodegenerative diseases. In Alzheimer's disease, the formation of amyloid-β...
MACiE
Gemma L Holliday, Gail J Bartlett, Daniel E Almonacid, Noel M O'Boyle, Peter Murray-Rust, Janet M Thornton, John BO Mitchell
Dec 19, 2005
Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition.
Meiosis is the cell division that halves the genetic component of diploid cells to form gametes or spores. To achieve this, meiotic cells undergo a radical spatial reorganisation of chromosomes. This reorganisation is a...
The origin of two-dimensional electron gases at oxide interfaces
The response of oxide thin films to polar discontinuities at interfaces and surfaces has generated enormous activity due to the variety of interesting effects that it gives rise to. A case in point is the discovery of the...
Non-Markovian modeling of protein folding.
Cihan Ayaz, Lucas Tepper, Florian N Brünig, Julian Kappler, Jan O Daldrop, Roland R Netz
Aug 30, 2021
We extract the folding free energy landscape and the time-dependent friction function, the two ingredients of the generalized Langevin equation (GLE), from explicit-water molecular dynamics (MD) simulations of the α-helix...
Phosphopeptide interactions with BRCA1 BRCT domains
BRCA1 BRCT DNA damage response Phosphopeptide Tandem BRCT domains pSXXF motif Amino Acid Motifs Amino Acid Sequence BRCA1 Protein Binding Sites Computer Simulation DNA Damage DNA Repair Models Chemical Models Molecular Molecular Sequence Data Phosphopeptides Protein Binding Protein Conformation Protein Structure Tertiary
|
|< |
< |
1 |