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IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.
Hung-Chang Chen, Nils Eling, Celia Pilar Martinez-Jimenez, Louise McNeill O'Brien, Valentina Carbonaro, John C Marioni, Duncan T Odom, Maike de la Roche
Jun 03, 2019
IL-7 Ageing lymph node tumour response γδ T-cell lineage aging Animals Carcinoma Lewis Lung Cell Differentiation Cell Lineage Gene Expression Regulation Neoplastic Immunophenotyping Interleukin-17 Interleukin-7 Lymph Nodes Mice Mice Inbred C57BL Receptors Antigen T-Cell gamma-delta Signal Transduction T-Lymphocyte Subsets Tumor Burden
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.
Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Elizabeth Allen, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, James Dooley, Louis Boon, Julia Katharina Schwarze, Frank Tacke, Kiavash Movahedi, Niels Vandamme, Bart Neyns, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Damya Laoui, Jo Agnes Van Ginderachter
Mar 30, 2021
BACKGROUND: Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the...
Biomarkers immunologic Immunotherapy Lymphocytes Receptors tumor tumor-infiltrating Animals Antineoplastic Agents Immunological Carcinoma Lewis Lung Combined Modality Therapy Databases Genetic Female Gene Expression Profiling Humans Immune Checkpoint Inhibitors Lung Neoplasms Lymphocyte Depletion Lymphocytes Tumor-Infiltrating Melanoma Experimental Mice Inbred C57BL Mice Knockout Molecular Targeted Therapy Phenotype Programmed Cell Death 1 Receptor RNA-seq Receptors CCR8 Skin Neoplasms T-Lymphocytes Regulatory