Search
Results: 846
Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.
Marisa W Friederich, Sharita Timal, Christopher A Powell, Cristina Dallabona, Alina Kurolap, Sara Palacios-Zambrano, Drago Bratkovic, Terry GJ Derks, David Bick, Katelijne Bouman, Kathryn C Chatfield, Nadine Damouny-Naoum, Megan K Dishop, Tzipora C Falik-Zaccai, Fuad Fares, Ayalla Fedida, Ileana Ferrero, Renata C Gallagher, Rafael Garesse, Micol Gilberti, Cristina González, Katherine Gowan, Clair Habib, Rebecca K Halligan, Limor Kalfon, Kaz Knight, Dirk Lefeber, Laura Mamblona, Hanna Mandel, Adi Mory, John Ottoson, Tamar Paperna, Ger JM Pruijn, Pedro F Rebelo-Guiomar, Ann Saada, Bruno Sainz, Hayley Salvemini, Mirthe H Schoots, Jan A Smeitink, Maciej J Szukszto, Hendrik J Ter Horst, Frans van den Brandt, Francjan J van Spronsen, Joris A Veltman, Eric Wartchow, Liesbeth T Wintjes, Yaniv Zohar, Miguel A Fernández-Moreno, Hagit N Baris, Claudia Donnini, Michal Minczuk, Richard J Rodenburg, Johan LK Van Hove
Dec 07, 2018
Mitochondrial protein synthesis requires charging mt-tRNAs with their cognate amino acids by mitochondrial aminoacyl-tRNA synthetases, with the exception of glutaminyl mt-tRNA (mt-tRNAGln). mt-tRNAGln is indirectly charged by a...
Amino Acid Sequence Cardiomyopathies Female FIBROBLASTS Humans Infant Infant Newborn Lentivirus Male Mitochondrial Diseases Models Molecular Mutation Myocardium Nitrogenous Group Transferases Oxidative Phosphorylation Pedigree Protein Biosynthesis Protein Subunits RNA Transfer Saccharomyces cerevisiae
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein
Michael D Crabtree, Wade Borcherds, Anusha Poosapati, Sarah L Shammas, Gary W Daughdrill, Jane Clarke
Mar 26, 2018
Appropriate integration of cellular signals requires a delicate balance of ligand-target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in...
Amino Acid Sequence Animals Binding Sites Cloning Molecular Conserved Sequence Escherichia coli Gene Expression Histone-Lysine N-Methyltransferase Humans Intrinsically Disordered Proteins Membrane Proteins Mice Models Molecular Mutation Myeloid-Lymphoid Leukemia Protein Phosphoproteins Proline Protein Binding Protein Conformation alpha-Helical Protein Folding Protein Interaction Domains and Motifs Recombinant Proteins Sequence Alignment Sequence Homology Amino Acid Tumor Suppressor Protein p53
Gene exchange drives the ecological success of a multi-host bacterial pathogen.
Emily J Richardson, Rodrigo Bacigalupe, Ewan M Harrison, Lucy A Weinert, Samantha Lycett, Manouk Vrieling, Kirsty Robb, Paul A Hoskisson, Matthew TG Holden, Edward J Feil, Gavin K Paterson, Steven YC Tong, Adebayo Shittu, Willem van Wamel, David M Aanensen, Julian Parkhill, Sharon J Peacock, Jukka Corander, Mark Holmes, J Ross Fitzgerald
Sep 29, 2018
The capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and...
Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome.
Mallory C Shields, Matthew R Bowers, McKenzie M Fulcer, Madelyn K Bollig, Patrick J Rock, Bryan R Sutton, Alysia D Vrailas-Mortimer, Hanns Lochmüller, Roger G Whittaker, Rita Horvath, Noreen E Reist
Mar 07, 2019
During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human...
CyanoGate
Ravendran Vasudevan, Grant AR Gale, Alejandra A Schiavon, Anton Puzorjov, John Malin, Michael D Gillespie, Konstantinos Vavitsas, Valentin Zulkower, Baojun Wang, Christopher J Howe, David J Lea-Smith, Alistair J McCormick
Mar 14, 2019
Recent advances in synthetic biology research have been underpinned by an exponential increase in available genomic information and a proliferation of advanced DNA assembly tools. The adoption of plasmid vector assembly...
Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor.
How release of phosphate from mammalian F1-ATPase generates a rotary substep.
The rotation of the central stalk of F1-ATPase is driven by energy derived from the sequential binding of an ATP molecule to its three catalytic sites and the release of the products of hydrolysis. In human F1-ATPase, each 360°...
ATP synthase Mitochondria phosphate release rotary substep Adenosine Diphosphate Animals Catalytic Domain Cattle Crystallography X-Ray Humans Hydrolysis Mitochondria Models Molecular Molecular Motor Proteins Phosphates Protein Binding Protein Structure Secondary Proton-Translocating ATPases Temperature
Instabilities of High Speed Dislocations.
Despite numerous theoretical models and simulation results, a clear physical picture of dislocations traveling at velocities comparable to the speed of sound in the medium remains elusive. Using two complementary atomistic...
De novo design of potent and selective mimics of IL-2 and IL-15.
Daniel-Adriano Silva, Shawn Yu, Umut Y Ulge, Jamie B Spangler, Kevin M Jude, Carlos Labão-Almeida, Lestat R Ali, Alfredo Quijano-Rubio, Mikel Ruterbusch, Isabel Leung, Tamara Biary, Stephanie J Crowley, Enrique Marcos, Carl D Walkey, Brian D Weitzner, Fátima Pardo-Avila, Javier Castellanos, Lauren Carter, Lance Stewart, Stanley R Riddell, Marion Pepper, Gonçalo JL Bernardes, Michael Dougan, K Christopher Garcia, David Baker
Jan 29, 2019
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. We use this strategy to design mimics...
Amino Acid Sequence Animals Binding Sites Colonic Neoplasms Computer Simulation Crystallography X-Ray Disease Models Animal Drug Design Humans Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Melanoma Mice Models Molecular Molecular Mimicry Protein Stability Receptors Interleukin-2 Signal Transduction
Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.
Kathryn Holt, Johanna J Kenyon, Mohammad Hamidian, Mark B Schultz, Derek J Pickard, Gordon Dougan, Ruth Hall
Jun 25, 2018
The majority of Acinetobacter baumannii isolates that are multiply, extensively and pan-antibiotic resistant belong to two globally disseminated clones, GC1 and GC2, that were first noticed in the 1970s. Here, we investigated...
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
Yavuz Kulaberoglu, Kui Lin, Maxine Holder, Zhongchao Gai, Marta Gomez, Belul Assefa Shifa, Merdiye Mavis, Lily Hoa, Ahmad AD Sharif, Celia Lujan, Ewan St John Smith, Ivana Bjedov, Nicolas Tapon, Geng Wu, Alexander Hergovich
Jul 12, 2018
The Hippo tumor suppressor pathway is essential for development and tissue growth control, encompassing a core cassette consisting of the Hippo (MST1/2), Warts (LATS1/2), and Tricornered (NDR1/2) kinases together with MOB1 as an...
Functional Alleles of Chicken BG Genes, Members of the Butyrophilin Gene Family, in Peripheral T Cells.
B-G B7 family Adaptive Immunity innate immunity Membrane Protein Alleles Alternative Splicing Amino Acid Sequence Animals Butyrophilins Chickens Cloning Molecular Exons Gene Expression Haplotypes Introns Models Molecular Multigene Family Phylogeny Protein Conformation Sequence Analysis DNA Structure-Activity Relationship T-Lymphocytes
2'-Alkynylnucleotides
Marius M Haugland, Afaf H El-Sagheer, Rachel J Porter, Javier Peña, Tom Brown, Edward A Anderson, Janet E Lovett
Jan 26, 2018
Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible...
Phenotypes can be robust and evolvable if mutations have non-local effects on sequence constraints.
The mapping between biological genotypes and phenotypes plays an important role in evolution, and understanding the properties of this mapping is crucial to determine the outcome of evolutionary processes. One of the most...
Approximating Matsubara dynamics using the planetary model
Matsubara dynamics is the quantum-Boltzmann-conserving classical dynamics which remains when real-time coherences are taken out of the exact quantum Liouvillian [T. J. H. Hele et al., J. Chem. Phys. 142, 134103 (2015)]; because...
Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions
Selective sweep on human amylase genes postdates the split with Neanderthals
CE Inchley, CDA Larbey, NAA Shwan, L Pagani, L Saag, T Antão, G Jacobs, G Hudjashov, E Metspalu, M Mitt, CA Eichstaedt, B Malyarchuk, M Derenko, J Wee, S Abdullah, F-X Ricaut, M Mormina, R Mägi, R Villems, M Metspalu, MK Jones, JAL Armour, T Kivisild
May 02, 2017
Structural Basis for Mitotic Centrosome Assembly in Flies.
Zhe Feng, Anna Caballe, Alan Wainman, Steven Johnson, Andreas FM Haensele, Matthew A Cottee, Paul T Conduit, Susan M Lea, Jordan W Raff
Aug 18, 2017
Ultrasmall silica nanoparticles directly ligate the T cell receptor complex.
Bradley Vis, Rachel E Hewitt, Tom P Monie, Camilla Fairbairn, Suzanne D Turner, Stephen D Kinrade, Jonathan J Powell
Jan 09, 2020
Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice.
Catriona P Harkins, Bruno Pichon, Michel Doumith, Julian Parkhill, Henrik Westh, Alexander Tomasz, Herminia de Lencastre, Stephen D Bentley, Angela M Kearns, Matthew TG Holden
Jan 10, 2020
BACKGROUND: The spread of drug-resistant bacterial pathogens poses a major threat to global health. It is widely recognised that the widespread use of antibiotics has generated selective pressures that have driven the emergence...
Comparative Genomics
Duncan T Odom
Jan 31, 2020
Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate.
3D complex
Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data...
|
|< |
< |
1 |