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Are There Hidden Genes in DNA/RNA Vaccines?

Christopher A Beaudoin, Martin Bartas, Adriana Volná, Petr Pečinka, Tom L Blundell

Feb 22, 2022

Due to the fast global spreading of the Severe Acute Respiratory Syndrome Coronavirus - 2 (SARS-CoV-2), prevention and treatment options are direly needed in order to control infection-related morbidity, mortality, and economic...

DNA vaccine ORF-Sh ORF2b RNA vaccine SARS-CoV-2 codon optimization spike protein COVID-19 Vaccines Codon Genes Overlapping Genes Viral Humans Nucleic Acid Conformation Open Reading Frames Protein Biosynthesis Protein Domains RNA Messenger Spike Glycoprotein Coronavirus vaccines DNA mRNA Vaccines

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Cover Image for Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes.

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Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes.

Angelo Pavesi, Alberto Vianelli, Nicola Chirico, Yiming Bao, Olga Blinkova, Robert Belshaw, Andrew Firth, David Karlin

Sep 21, 2018

Overlapping genes represent a fascinating evolutionary puzzle, since they encode two functionally unrelated proteins from the same DNA sequence. They originate by a mechanism of overprinting, in which point mutations in an...

Amino Acid Sequence Animals evolution Molecular Genes Overlapping Genes Viral Mammals Mutation Open Reading Frames principal component analysis Proteins

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