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Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic homeostasis hypothesis suggests that synaptic connections are strengthened during wake and downscaled during sleep; however, it is...

LTD LTP STDP Up-Down state in vivo MOUSE network oscillations Sleep Somatosensory Cortex Animals Excitatory Postsynaptic Potentials Female Male Mice Mice 129 Strain Mice Transgenic Neuronal Plasticity Sleep Slow-Wave Synapses

Sleep spindles are distinctive transient patterns of brain activity that typically occur during non-rapid eye movement (NREM) sleep in humans and other mammals. Thought to be important for the consolidation of learning, they may...

Automated detection awake EEG learning Slow waves Spectral analysis wake spindles Animals Electroencephalography learning polysomnography Sheep Sleep Sleep Slow-Wave

Slow-wave sleep is characterized by near-synchronous alternation of active Up states and quiescent Down states in the neocortex. Although the cortex itself can maintain these oscillations, the full expression of Up-Down states...

GABAergic interneuron Up-Down states INHIBITION in vivo MOUSE non-specific thalamic nuclei Slow oscillation slow-wave sleep synchronization thalamocortical Animals Evoked Potentials Female Interneurons Male Mice Mice Inbred C57BL Neocortex Receptors GABA-B Sleep Slow-Wave Thalamus