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Results: 17
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
B Lo, ADE Swafford, KA Shafer-Weaver, LF Jerome, L Rakhlin, DR Mathern, CA Callahan, P Jiang, LJ Davison, HE Stevens, CL Lucas, J White, R von Borstel, JA Todd, MJ Lenardo
Feb 21, 2012
Clinical Research Prevention Autoimmune Disease Diabetes 4.2 Evaluation of markers and technologies 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Metabolic and endocrine Animals Autoantibodies Diabetes mellitus Type 1 Disease Progression Electrochemistry Female Humans Insulin Antibodies Insulin-Secreting Cells Luminescent Measurements Mice Mice Inbred NOD ROC Curve Radioligand Assay Reproducibility of Results Sensitivity and Specificity
Can screening for degenerative cervical myelopathy (SCREEN-DCM) be effectively undertaken based on signs, symptoms and known risk factors? Rationale and research protocol for a prospective, multicentre, observational study
Introduction Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord impairment. Unfortunately, the condition remains poorly recognised and underdiagnosed. To...
A Nouri, G Molliqaj, R Gondar, A Lavé, G Jannelli, B Davies, M Kotter, A Martin, J Virojanapa, JS Cheng, T Somma, P Cappabianca, CLA Vleggeert-Lankamp, V Ter Wengel, T Meling, K Schaller, E Tessitore
Jul 21, 2022
Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
Nguyen Duc Toan, Thomas C Darton, Nguyen Hoang Thien Huong, Le Thanh Hoang Nhat, To Nguyen Thi Nguyen, Ha Thanh Tuyen, Le Quoc Thinh, Nguyen Kien Mau, Pham Thi Thanh Tam, Cam Ngoc Phuong, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Ngo Minh Xuan, Tang Chi Thuong, Nguyen Thanh Hung, Christine Boinett, Stephen Reece, Abhilasha Karkey, Jeremy N Day, Stephen Baker
Sep 02, 2022
Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there...
Patient Safety Infant Mortality Hematology Sepsis Pediatric Clinical Research Infectious Diseases Perinatal Period - Conditions Originating in Perinatal Period 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Infection Inflammatory and immune system 3 Good Health and Well Being
Therapeutic and diagnostic advances in Stickler syndrome
The Stickler syndromes are the leading cause of inherited retinal detachment and the most common cause of rhegmatogenous retinal detachment in childhood. The clinical and molecular genetic spectrum of this connective...
Martin Snead, Howard Martin, Peter Bale, Nick Shenker, David Baguley, Philip Alexander, Annie McNinch, Arabella Poulson
Dec 10, 2020
Transomental defects as a cause of chronic abdominal pain, the role of diagnostic laparoscopy
Optimization of Nanosubstrates toward Molecularly Surface-Functionalized Raman Spectroscopy.
Paulo De Carvalho Gomes, Mike Hardy, Yazmin Tagger, Jonathan James Stanley Rickard, Paula Mendes, Pola Goldberg Oppenheimer
Sep 26, 2022
Diagnostic advancements require continuous developments of reliable analytical sensors, which can simultaneously fulfill many criteria, including high sensitivity and specificity for a broad range of target analytes....
The role of [68 Ga]Ga-DOTATATE PET/CT in wild-type KIT/PDGFRA gastrointestinal stromal tumours (GIST).
Luigi Aloj, Olivier Giger, Iosif A Mendichovszky, Ben G Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A Gallagher, Bala Attili, Mary McLean, Robin L Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R Maher, Ruth T Casey
Mar 26, 2021
BACKGROUND: [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor...
DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression.
Tamar Paz-Elizur, Yael Leitner-Dagan, Kerstin B Meyer, Barak Markus, Federico M Giorgi, Martin O'Reilly, Hyunjin Kim, Yentl Evgy, Ronen Fluss, Laurence S Freedman, Robert C Rintoul, Bruce Ponder, Zvi Livneh
Apr 22, 2020
Proactive breast cancer risk assessment in primary care
Juliet A Usher-Smith, Sarah Hindmarch, David P French, Marc Tischkowitz, Sowmiya Moorthie, Fiona M Walter, Rebecca A Dennison, Francisca Stutzin Donoso, Stephanie Archer, Lily Taylor, Jon Emery, Stephen Morris, Douglas F Easton, Antonis C Antoniou
Mar 06, 2023
Early constipation predicts faster dementia onset in Parkinson's disease.
M Camacho, AD Macleod, J Maple-Grødem, JR Evans, DP Breen, G Cummins, RS Wijeyekoon, JC Greenland, G Alves, OB Tysnes, RA Lawson, RA Barker, CH Williams-Gray
Jan 21, 2021
aging Parkinson's Disease Brain Disorders Acquired Cognitive Impairment Neurodegenerative Dementia Neurosciences Clinical Research 4 Detection screening and diagnosis 4.2 Evaluation of markers and technologies 4.1 Discovery and preclinical testing of markers and technologies 2.1 Biological and endogenous factors 2 Aetiology Neurological
Progression to Dementia in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease.
Calum A Hamilton, Fiona E Matthews, Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Rory Durcan, Gemma Roberts, Joanna Ciafone, Sally AH Barker, Michael Firbank, Ian G McKeith, Alan J Thomas
Mar 04, 2021
Dementia Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer's Disease Related Dementias (ADRD) Acquired Cognitive Impairment Neurosciences Clinical Research Neurodegenerative Alzheimer's Disease Brain Disorders aging 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis 2.1 Biological and endogenous factors 2 Aetiology Neurological
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy.
J Lei, A Rudolph, KB Moysich, S Rafiq, S Behrens, EL Goode, PD Pharoah, P Seibold, PA Fasching, IL Andrulis, VN Kristensen, FJ Couch, U Hamann, MJ Hooning, H Nevanlinna, U Eilber, MK Bolla, J Dennis, Q Wang, A Lindblom, A Mannermaa, D Lambrechts, M García-Closas, P Hall, G Chenevix-Trench, M Shah, R Luben, L Haeberle, AB Ekici, MW Beckmann, JA Knight, G Glendon, S Tchatchou, GI Alnæs, AL Borresen-Dale, S Nord, JE Olson, E Hallberg, C Vachon, D Torres, HU Ulmer, T Rüdiger, A Jager, CH van Deurzen, MM Tilanus-Linthorst, TA Muranen, K Aittomäki, C Blomqvist, S Margolin, VM Kosma, JM Hartikainen, V Kataja, S Hatse, H Wildiers, A Smeets, J Figueroa, SJ Chanock, J Lissowska, J Li, K Humphreys, KA Phillips, kConFab Investigators, S Linn, S Cornelissen, SA van den Broek, D Kang, JY Choi, SK Park, KY Yoo, CN Hsiung, PE Wu, MF Hou, CY Shen, SH Teo, NA Taib, CH Yip, GF Ho, K Matsuo, H Ito, H Iwata, K Tajima, AM Dunning, J Benitez, K Czene, LE Sucheston, T Maishman, WJ Tapper, D Eccles, DF Easton, MK Schmidt, J Chang-Claude
Jun 17, 2019
Breast Cancer Genetics Cancer 2.1 Biological and endogenous factors 2 Aetiology 4.2 Evaluation of markers and technologies 4 Detection screening and diagnosis Cancer Adult Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Breast Neoplasms Female Genomics Humans immunomodulation Interleukin-12 Subunit p40 Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Staging Polymorphism Single Nucleotide Prognosis Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type II Receptors Estrogen Receptors Transforming Growth Factor beta Signal Transduction Treatment Outcome Tumor Burden
MicroRNA profiling of low concentration extracellular vesicle RNA utilizing NanoString nCounter technology
Rachel E Crossland, Anna Albiero, Clara Sanjurjo‐Rodríguez, Monica Reis, Anastasia Resteu, Amy E Anderson, Anne M Dickinson, Arthur G Pratt, Mark Birch, Andrew W McCaskie, Elena Jones, Xiao‐nong Wang
Jan 29, 2023
Extracellular vesicles (EV) and the microRNAs that they contain are increasingly recognised as a rich source of informative biomarkers, reflecting pathological processes and fundamental biological pathways and responses. Their...
Neurofilament light chain predicts future dementia risk in cerebral small vessel disease.
Marco Egle, Laurence Loubiere, Aleksandra Maceski, Jens Kuhle, Nils Peters, Hugh S Markus
Feb 10, 2021
aging Dementia Prevention Brain Disorders Biomedical Imaging Clinical Trials and Supportive Activities Acquired Cognitive Impairment Behavioral and Social Science Neurosciences Neurodegenerative Clinical Research 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis 4.2 Evaluation of markers and technologies Neurological
Accurate detection of benign and malignant renal tumor subtypes with MethylBoostER
Sabrina H Rossi, Izzy Newsham, Sara Pita, Kevin Brennan, Gahee Park, Christopher G Smith, Radoslaw P Lach, Thomas Mitchell, Junfan Huang, Anne Babbage, Anne Y Warren, John T Leppert, Grant D Stewart, Olivier Gevaert, Charles E Massie, Shamith A Samarajiwa
Oct 29, 2022
[11C]PK11195-PET brain imaging of the mitochondrial translocator protein in mitochondrial disease
Patrick Chinnery
Mar 08, 2021
¬¬¬Abstract
Objective: To explore the possibilities of radioligands against the mitochondrial outer membrane protein TSPO as biomarkers for mitochondrial disease, we performed positron emission tomography (PET)-MR brain imaging...