Search

Results: 11

Cover Image for Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.

Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.

David L Prole, Colin W Taylor

Nov 19, 2015

Animals Calcium Signaling Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Membrane Proteins Signal Transduction

Published by:

Cover Image for Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.

Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.

Abha Meena, Stephen C Tovey, Colin W Taylor

Feb 10, 2015

Ca2+ signalling Cyclic AMP Inositol trisphosphate receptor Parathyroid hormone Adenylyl Cyclases Calcium Calcium Signaling Carbachol Colforsin Cyclic AMP Cyclic AMP-Dependent Protein Kinases Cytosol HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Parathyroid Hormone Receptor Parathyroid Hormone Type 1

Published by:

$Cover Image for Cyclic AMP Recruits a Discrete Intracellular Ca$^{2+}$ Store by Unmasking Hypersensitive IP$_{3}$ Receptors$ View Article

Cyclic AMP Recruits a Discrete Intracellular Ca$^{2+}$ Store by Unmasking Hypersensitive IP$_{3}$ Receptors

V Konieczny, SC Tovey, S Mataragka, DL Prole, CW Taylor

Mar 10, 2017

Cyclic AMP Endoplasmic Reticulum Inositol 1 4 5-Trisphosphate intracellular Ca(2+) store IRBIT Golgi Apparatus Parathyroid hormone phospholipase C

Published by:

Cover Image for Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes.

Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes.

Maria Jimena Amaya, André G Oliveira, Lena K Schroeder, Edward S Allgeyer, Joerg Bewersdorf, Michael H Nathanson

Jun 07, 2021

Extended synaptotagmins (E-Syts) are a recently identified family of proteins that tether the endoplasmic reticulum (ER) to the plasma membrane (PM) in part by conferring regulation of cytosolic calcium (Ca2+) at these contact...

Animals Calcium Calcium Signaling Cells Cultured Hepatocytes Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Male RNA Interference Rats Rats Sprague-Dawley Synaptotagmins

Published by:

Cover Image for Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.

Cristina I López Sanjurjo, Stephen C Tovey, Colin W Taylor

Oct 13, 2014

Calcium Calcium Signaling Carbachol Cell Line Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Lysosomes NADP

Published by:

Cover Image for Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.

Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.

Aneesh Chandran, Xavier Chee, David L Prole, Taufiq Rahman

Apr 30, 2019

Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 Å away from the IP3-binding core (IBC). However, the precise...

Allosteric Regulation Animals Calcium Hydrogen Bonding Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Mice Models Molecular Molecular Dynamics Simulation Protein Binding Protein Conformation

Published by:

Cover Image for IP3 receptors

Cover Image for Analyses of Ligand Binding to IP3 Receptors Using Fluorescence Polarization.

Analyses of Ligand Binding to IP3 Receptors Using Fluorescence Polarization.

Ana M Rossi, Colin W Taylor

Jan 16, 2019

Fluorescence polarization (FP) can be used to measure binding of a small fluorescent ligand to a larger protein because the ligand rotates more rapidly in its free form than when bound. When excited with plane polarized light...

affinity Fluorescence Polarization IP3 receptor Ligand binding Thermodynamics Entropy Fluorescence Polarization Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Ligands Thermodynamics

Published by:

Cover Image for IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans.

IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans.

Anikó I Nagy, Rafael P Vázquez-Manrique, Marie Lopez, Christo P Christov, María Dolores Sequedo, Mareike Herzog, Anna E Herlihy, Maxime Bodak, Roxani Gatsi, Howard A Baylis

Feb 19, 2015

C. elegans RNA Interference calcium signalling enhanced RNAi Inositol 1 4 5‐trisphosphate Animals Caenorhabditis elegans Image Processing Computer-Assisted Inositol 1 4 5-Trisphosphate Intestinal Mucosa Microscopy Fluorescence Models Biological RNA Interference RNA Double-Stranded Signal Transduction

Published by:

Cover Image for A tale of two inositol trisphosphates.

A tale of two inositol trisphosphates.

Robin Irvine

Nov 25, 2015

Calcium inositol inositol phosphates inositol trisphosphate Animals History 20th Century History 21st Century Humans Inositol 1 4 5-Trisphosphate Inositol Phosphates

Published by:

Cover Image for Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3

Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3

Colin Taylor, Andrew M Riley, Genevieve Dupont, Taufiq Rahman, Barry VL Potter, Ana M Rossi

Apr 14, 2022

Ca(2+) signaling IP(3) receptor IP(3) receptor antagonist Endoplasmic Reticulum intracellular Ca(2+) stores partial agonist quantal Ca(2+) release receptor inactivation Animals Calcium Calcium Signaling Chickens Drug Partial Agonism Endoplasmic Reticulum HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors inositol phosphates Time Factors

Published by: