Search

Advances in sequencing technology have led to the introduction of panel testing in hereditary breast and ovarian cancer. While direct-to-consumer testing services have become widely available, the clinical validity of many of...

Breast Cancer gene panel genetic testing and hereditary cancer ovarian cancer AMP-Activated Protein Kinase Kinases Antigens CD Cadherins DNA-Binding Proteins Epithelial Cell Adhesion Molecule Female Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease Genetic Testing Hereditary Breast and Ovarian Cancer Syndrome High-Throughput Nucleotide Sequencing Humans Li-Fraumeni Syndrome Lynch Syndrome II MutL Protein Homolog 1 MutS Homolog 2 Protein PTEN Phosphohydrolase Peutz-Jeghers Syndrome Protein Serine-Threonine Kinases Sequence Analysis DNA Tumor Suppressor Protein p53

BACKGROUND: Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway....

AMP-Activated Protein Kinase Kinases Animals Breast Neoplasms Cell Proliferation Diabetes mellitus Fatty Acids Female Gene Expression Profiling Gene Expression Regulation Neoplastic Heterografts Humans Lipid Metabolism Lipid Peroxidation Metformin Mice Mitochondria Oxidation-Reduction Protein Kinases Transcriptome

AMPK Autophagy PIKfyve Ptdins5P ULK1 glucose starvation AMP-Activated Protein Kinase Kinases Animals Autophagosomes Autophagy-Related Protein-1 Homolog Glucose Humans Intracellular Signaling Peptides and Proteins Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phosphorylation Signal Transduction

AMPK PI(5)P PIKfyve ULK1 Autophagy glucose starvation mTOR phagophore AMP-Activated Protein Kinase Kinases Autophagosomes Autophagy Autophagy-Related Protein-1 Homolog Cell Line Gene Expression Regulation Glucose Humans metabolism Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phospholipids Protein Kinases Signal Transduction