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Cover Image for MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics View Article
MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
TA Masters, DA Tumbarello, MV Chibalina, F Buss
Jul 26, 2017
APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these...
AKT activation APPL1 endosomes cortical actin membrane ruffling myosin VI unconventional myosins Actins Adaptor Proteins Signal Transducing Animals Cell Line Endosomes Enzyme Activation Mice Myosin Heavy Chains Proto-Oncogene Proteins c-akt Signal Transduction
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