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Results: 30
Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.
Bernhard Strauss, Andrew Harrison, Paula Almeida Coelho, Keiko Yata, Magdalena Zernicka-Goetz, Jonathon Pines
May 02, 2018
There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential...
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Hebin Liu, Helga Schneider, Asha Recino, Christine Richardson, Martin W Goldberg, Christopher E Rudd
Aug 18, 2015
Active Transport Cell Nucleus Adaptor Proteins Signal Transducing Animals Cell Line GTPase-Activating Proteins Humans Jurkat Cells Mice Microscopy Electron Transmission NFATC Transcription Factors Nuclear Pore Phosphoproteins Protein Binding Small Ubiquitin-Related Modifier Proteins T-Lymphocytes Transcription Factor RelA
Rethinking walkability and developing a conceptual definition of active living environments to guide research and practice.
Melissa Tobin, Samantha Hajna, Kassia Orychock, Nancy Ross, Megan DeVries, Paul J Villeneuve, Lawrence D Frank, Gavin R McCormack, Rania Wasfi, Madeleine Steinmetz-Wood, Jason Gilliland, Gillian L Booth, Meghan Winters, Yan Kestens, Kevin Manaugh, Daniel Rainham, Lise Gauvin, Michael J Widener, Nazeem Muhajarine, Hui Luan, Daniel Fuller
Apr 08, 2022
BACKGROUND: Walkability is a popular term used to describe aspects of the built and social environment that have important population-level impacts on physical activity, energy balance, and health. Although the term is widely...
piRNA-guided co-transcriptional silencing coopts nuclear export factors.
Martin H Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A Falconio, Gregory J Hannon, Benjamin Czech
Jun 21, 2019
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part...
D. melanogaster PIWI proteins Chromosomes Gene Expression nuclear export factor piRNA pathway transcriptional gene silencing transposon control Active Transport Cell Nucleus Animals Chromatin Drosophila melanogaster Gene Silencing Nuclear Proteins Protein Binding Protein Stability RNA Small Interfering Transcription Genetic
A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.
Robert Mahen, Hiroyoshi Hattori, MiYoung Lee, Pooja Sharma, Anand D Jeyasekharan, Ashok R Venkitaraman
Feb 18, 2020
A-type lamins encoded by LMNA form a structural fibrillar meshwork within the mammalian nucleus. How this nuclear organization may influence the execution of biological processes involving DNA transactions remains unclear. Here...
Towards Sustainable Urban Transportation in Ghana
RA Acheampong
Sep 12, 2017
Cycling is considered an environmentally-friendly mode of transport that offers many personal benefits including health, affordability and flexibility of travel. To encourage more people to cycle, especially in contexts where...
Cycling in Warsaw, Poland - Perceived enablers and barriers according to cyclists and non-cyclists.
Katarzyna Iwińska, Malgorzata Blicharska, Livia Pierotti, Marko Tainio, Audrey de Nazelle
Jul 31, 2018
Cycling in urban environments provides many benefits to people. However, planning of cycling infrastructures in large cities faces numerous challenges and requires better understanding of both the factors enabling cycling as...
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.
Hepatocyte nuclear factor-1β (HNF1β) Importin-α Isothermal titration calorimetry Nuclear import pathway Nuclear localisation signal sequence (NLS) Site-directed mutagenesis X-ray crystallography Active Transport Cell Nucleus Animals Binding Sites Cell Line Tumor Cell Nucleus Crystallography X-Ray HEK293 Cells Hepatocyte Nuclear Factor 1-beta Humans Mice Models Molecular Nuclear Localization Signals Protein Binding Protein Conformation alpha-Helical Sequence Analysis Protein Xenopus Proteins Xenopus laevis alpha Karyopherins
Children's Transport Built Environments
Melody Smith, Rebecca Amann, Alana Cavadino, Deborah Raphael, Robin Kearns, Roger Mackett, Lisa Mackay, Penelope Carroll, Euan Forsyth, Suzanne Mavoa, Jinfeng Zhao, Erika Ikeda, Karen Witten
Jan 06, 2020
Children's independent mobility is declining internationally. Parents are the gatekeepers of children's independent mobility. This mixed methods study investigates whether parent perceptions of the neighbourhood environment...
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
Olga Sin, Tristan de Jong, Alejandro Mata-Cabana, Michelle Kudron, Mohamad Amr Zaini, Francesco A Aprile, Renée I Seinstra, Esther Stroo, Roméo Willinge Prins, Céline N Martineau, Hai Hui Wang, Wytse Hogewerf, Anne Steinhof, Erich E Wanker, Michele Vendruscolo, Cornelis F Calkhoven, Valerie Reinke, Victor Guryev, Ellen AA Nollen
Sep 09, 2019
Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer's and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive...
C. elegans MOAG-2/LIR-3 RNA Polymerase III Non-coding RNA polyglutamine protein aggregation Protein homeostasis protein quality control snoRNA tRNA Active Transport Cell Nucleus Animals Animals Genetically Modified Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Nucleus Cytosol Disease Models Animal Neurodegenerative Diseases Peptides Promoter Regions Genetic Protein Aggregates protein aggregation Pathological Protein Binding RNA Interference RNA Polymerase III RNA Small Untranslated Transcription Factors Transcription Genetic
Cross-sectional and longitudinal associations of active travel, organised sport and physical education with accelerometer-assessed moderate-to-vigorous physical activity in young people
Erika Ikeda, Justin M Guagliano, Andrew J Atkin, Lauren B Sherar, Ulf Ekelund, Bjørge Hansen, Kate Northstone, Esther van Sluijs, International Children’s Accelerometry Database (ICAD) Collaborators
May 09, 2022
CD82 controls CpG-dependent TLR9 signaling.
Nida S Khan, Daniel P Lukason, Marianela Feliu, Rebecca A Ward, Allison K Lord, Jennifer L Reedy, Zaida G Ramirez-Ortiz, Jenny M Tam, Pia V Kasperkovitz, Paige E Negoro, Tammy D Vyas, Shuying Xu, Melanie M Brinkmann, Mridu Acharaya, Katerina Artavanis-Tsakonas, Eva-Maria Frickel, Christine E Becker, Zeina Dagher, You-Me Kim, Eicke Latz, Hidde L Ploegh, Michael K Mansour, Cindy K Miranti, Stuart M Levitz, Jatin M Vyas
Oct 03, 2019
Function of the Nuclear Transport Machinery in Maintaining the Distinctive Compositions of the Nucleus and Cytoplasm.
Murray Stewart
Mar 02, 2022
Although the separation of transcription and translation, mediated by the nuclear envelope, is the defining characteristic of Eukaryotes, the barrier between the nuclear and cytoplasmic compartments needs to be semipermeable to...
Physical activity, screen time, and sleep duration of children aged 6-9 years in 25 countries
Stephen Whiting, Marta Buoncristiano, Peter Gelius, Karim Abu-Omar, Mary Pattison, Jolanda Hyska, Vesselka Duleva, Sanja Musić Milanović, Hana Zamrazilová, Tatjana Hejgaard, Mette Rasmussen, Eha Nurk, Lela Shengelia, Cecily C. Kelleher, Mirjam M. Heinen, Angela Spinelli, Paola Nardone, Akbota Abildina, Shynar Abdrakhmanova, Gulmira Aitmurzaeva, Zhamyila Usuopva, Iveta Pudule, Aušra Petrauskiene, Victoria Farrugia Sant'Angelo, Enisa Kujundzic, Stevo Popovic, Anne Siri Fismen, Ingunn Holden Bergh, Anna Fijalkowska, Ana Isabel Rito, Alexandra Cucu, Lacramioara Aurelia Brinduse, Valentina Peterkova, Andrea Gualtieri, Marta García-Solano, Enrique Gutiérrez-González, Zulfinissio Abdurrahmonova, Khadichamo Boymatova, Nazan Yardim, Maya Tanrygulyyeva, Daniel Weghuber, Karin Schindler, Dragana Stojisavljević, Aida Filipović Hadžiomeragić, Eliza Markidou Ionnaidu, Wolfgang Ahrens, Maria Hassapidou, Viktoria Anna Kovacs, Sergej M. Ostojic, Lubica Ticha, Gregor Starc, Kenisha Russell Jonsson, Igor Spiroski, Harry Rutter, Romeu Mendes, Julianne Williams, Ivo Rakovac, João Breda
Mar 01, 2021
Background: Children are becoming less physically active as opportunities for safe active play, recreational activities, and active transport decrease. At the same time, sedentary screen-based activities both during school...
Active play Active Transport Physical inactivity Sedentary behaviour SURVEILLANCE /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2737 name=Physiology (medical) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Francesco Paonessa, Lewis D Evans, Ravi Solanki, Delphine Larrieu, Selina Wray, John Hardy, Stephen P Jackson, Frederick J Livesey
Feb 05, 2019
The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal dementia (FTD), but the underlying pathogenic...
The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import.
Maxime Veillette, Katsiaryna Bichel, Paulina Pawlica, Stefan MV Freund, Mélodie B Plourde, Quang Toan Pham, Carlos Reyes-Moreno, Leo C James, Lionel Berthoux
Mar 06, 2013
Motivation and active travel in adolescent girls and boys in Germany – Findings from the ARRIVE study
Denise Renninger, Anne Kelso, Anne K Reimers, Isabel Marzi, Franziska Beck, Elaine S Engels, Martyn Standage, Yolanda Demetriou
Oct 31, 2022
Active travel (using an active mode of transport such as walking or cycling) contributes to the accumulation of daily physical activity and thus holds potential for promoting health. To promote active travel among adolescents an...
Active Transport Behavioral regulation self-determination theory Sex/gender analysis Youth /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/3300/3313 name=Transportation /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology
Motivation and active travel in adolescent girls and boys in Germany – Findings from the ARRIVE study
Denise Renninger, Anne Kelso, Anne K Reimers, Isabel Marzi, Franziska Beck, Elaine S Engels, Martyn Standage, Yolanda Demetriou
Oct 31, 2022
Active travel (using an active mode of transport such as walking or cycling) contributes to the accumulation of daily physical activity and thus holds potential for promoting health. To promote active travel among adolescents an...
Active Transport Behavioral regulation self-determination theory Sex/gender analysis Youth /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/3300/3313 name=Transportation /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology
Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.
Active Transport Cell Nucleus Antineoplastic Agents Cell Line Tumor Cell Nucleus Chromosome Segregation HCT116 Cells HeLa Cells Humans Microscopy Confocal Mitogen-Activated Protein Kinases Mitosis Mutation Proto-Oncogene Proteins c-myc Proto-Oncogene Proteins p21(ras) RNA Interference Time-Lapse Imaging
Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.
Emma Kneuss, Marzia Munafò, Evelyn L Eastwood, Undine-Sophie Deumer, Jonathan B Preall, Gregory J Hannon, Benjamin Czech
Aug 13, 2019
The PIWI-interacting RNA (piRNA) pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilization. In Drosophila ovaries, most piRNAs originate from...
PIWI proteins RNA export nuclear export factor piRNA clusters transposon control Active Transport Cell Nucleus Animals DNA Transposable Elements Drosophila Drosophila Proteins Intracellular Signaling Peptides and Proteins Nucleocytoplasmic Transport Proteins RNA Precursors RNA Small Interfering RNA-Binding Proteins
Cross-sectional and longitudinal associations of active travel, organised sport and physical education with accelerometer-assessed moderate-to-vigorous physical activity in young people
mRNA localization in the Drosophila germline.
Timothy T Weil
Mar 08, 2016
Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway.
Delphine Larrieu, Emmanuelle Viré, Samuel Robson, Sophia Y Breusegem, Tony Kouzarides, Stephen P Jackson
Sep 20, 2018
Hutchinson-Gilford progeria syndrome (HGPS) is an incurable premature aging disease. Identifying deregulated biological processes in HGPS might thus help define novel therapeutic strategies. Fibroblasts from HGPS patients...
Active Transport Cell Nucleus Adult Aged 80 and over Case-Control Studies Cell Nucleus Cells Cultured Cellular Senescence Child Female FIBROBLASTS Humans Male Microtubules N-Terminal Acetyltransferase E N-Terminal Acetyltransferases Nuclear Pore Complex Proteins Phenotype progeria Proto-Oncogene Proteins Young Adult beta Karyopherins ran GTP-Binding Protein
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