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Results: 26
Insulin-like Growth Factor II
Amber N Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M Testai, Ekta Kumari, Deborah E Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L Wood, Steven W Levison
Apr 05, 2019
Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II...
IGF-II crypt of Lieberkühn intestinal stem cell neural stem cell Neurogenesis subgranular zone subventricular zone Adult stem cells Animals Biomarkers Brain Cell Differentiation Immunohistochemistry Insulin-Like Growth Factor II Intestines Mice Mice Knockout Mice Transgenic Neurogenesis Olfactory Bulb Organ Specificity Stem Cell Niche
Population dynamics of normal human blood inferred from somatic mutations.
Henry Lee-Six, Nina Friesgaard Øbro, Mairi S Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J Osborne, Brian JP Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O'Neill, Michael R Stratton, Elisa Laurenti, Anthony R Green, David G Kent, Peter J Campbell
Sep 21, 2018
Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells.
Emmanuel Than-Trong, Bahareh Kiani, Nicolas Dray, Sara Ortica, Benjamin Simons, Steffen Rulands, Alessandro Alunni, Laure Bally-Cuif
Jan 20, 2021
The cellular basis and extent of neural stem cell (NSC) self-renewal in adult vertebrates, and their heterogeneity, remain controversial. To explore the functional behavior and dynamics of individual NSCs, we combined genetic...
Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner.
Golnar Kolahgar, Saskia JE Suijkerbuijk, Iwo Kucinski, Enzo Z Poirier, Sarah Mansour, Benjamin D Simons, Eugenia Piddini
Jun 25, 2015
Stem cell niche organization in the Drosophila ovary requires the ECM component Perlecan.
Alfonsa Díaz-Torres, Alicia E Rosales-Nieves, John R Pearson, Carmen Santa-Cruz Mateos, Miriam Marín-Menguiano, Owen J Marshall, Andrea H Brand, Acaimo González-Reyes
Jan 28, 2021
Stem cells reside in specialized microenvironments or niches that balance stem cell proliferation and differentiation.1,2 The extracellular matrix (ECM) is an essential component of most niches, because it controls niche...
A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms.
Adult stem cells are important for tissue maintenance and repair. One key question is how such cells are specified and then protected from differentiation for a prolonged period. Investigating the maintenance of Drosophila...
D. melanogaster Notch Zfh1 developmental biology miRNA satellite cell Stem Cells Adult stem cells Animals Animals Genetically Modified Cell Differentiation Cells Cultured Drosophila Proteins Drosophila melanogaster Gene Expression Regulation Developmental MicroRNAs Myoblasts RNA Isoforms Repressor Proteins Zinc Finger E-box-Binding Homeobox 1
Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease.
Demyelinating diseases, such as multiple sclerosis (MS), are responsible for a significant portion of the neurological disability burden worldwide, especially in young adults. Demyelination can be followed by a spontaneous...
A practical and efficient cellular substrate for the generation of induced pluripotent stem cells from adults
I Geti, ML Ormiston, F Rouhani, M Toshner, M Movassagh, J Nichols, W Mansfield, M Southwood, A Bradley, AA Rana, L Vallier, NW Morrell
Jun 13, 2019
Adult Adult stem cells Animals Cell Culture Techniques Cell Differentiation Cell Lineage Endothelium Vascular Hematopoietic Stem Cells Humans Induced Pluripotent Stem Cells Karyotyping Leukocytes Mononuclear Mice Mice SCID Neoplasm Transplantation Nuclear Reprogramming Regenerative Medicine Stem Cell Transplantation Teratoma StemCellInstitute
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo, Meritxell Huch
Jun 28, 2016
Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4.
Louis Gervais, Marius van den Beek, Manon Josserand, Jérémy Sallé, Marine Stefanutti, Carolina N Perdigoto, Patricia Skorski, Khallil Mazouni, Owen J Marshall, Andrea H Brand, François Schweisguth, Allison J Bardin
Apr 26, 2019
Chromatin remodeling accompanies differentiation, however, its role in self-renewal is less well understood. We report that in Drosophila, the chromatin remodeler Kismet/CHD7/CHD8 limits intestinal stem cell (ISC) number and...
Cbl Drosophila midgut EGFR epigenetic Kismet/CHD7/CHD8 Proliferation control Trr/MLL3/4 Adult stem cells chromatin regulators Tissue homeostasis Animals Cell Differentiation Cell Proliferation Chromatin Chromatin Assembly and Disassembly DNA Helicases Drosophila Proteins Drosophila melanogaster ErbB Receptors Histone-Lysine N-Methyltransferase Histones Homeodomain Proteins RNA Polymerase II Receptors Invertebrate Peptide Signal Transduction Stem Cells Transcription Factors
Therapeutic revascularisation of ischaemic tissue
Christina L O'Neill, Michelle T O'Doherty, Sarah Ej Wilson, Amer A Rana, Claire E Hirst, Alan W Stitt, Reinhold J Medina
Jun 12, 2019
What's New in Orthopaedic Basic Science.
Matthew J Allen
Nov 14, 2016
Basic science studies remain a critically important part of
the knowledge-discovery process in musculoskeletal patient
care. This article highlights several of the key advances
in orthopaedic basic science over the past year. It...
Developmental mechanisms and adult stem cells for therapeutic lung regeneration.
Chronic degenerative lung diseases are essentially untreatable pathological conditions. By contrast, the healthy lung has numerous mechanisms that allow for rapid repair and restoration of function following minor acute...
Somatic growth and telomere dynamics in vertebrates
Much telomere loss takes place during the period of most rapid growth when cell proliferation and potentially energy expenditure are high. Fast growth is linked to reduced longevity. Therefore, the effects of somatic cell...
Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57KIP2/Dacapo.
Quiescent neural stem cells (NSCs) in the adult brain are regenerative cells that could be activated therapeutically to repair damage. It is becoming apparent that quiescent NSCs exhibit heterogeneity in their propensity for...
Dacapo G(0)/G(2) Brain Cell Cycle dorsal-ventral Heterogeneity neural stem cell p57 quiescence spatial patterning Adult stem cells Animals Cell Cycle Cell Division Cyclin-Dependent Kinase Inhibitor p57 Drosophila Proteins Drosophila melanogaster G2 Phase Homeodomain Proteins Neural Stem Cells Neurogenesis Nuclear Proteins Resting Phase Cell Cycle
Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.
Hedwig S Kruitwagen, Loes A Oosterhoff, Ingrid GWH Vernooij, Ingrid M Schrall, Monique E van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R Molenaar, J Bernd Helms, Guy CM Grinwis, Monique MA Verstegen, Luc JW van der Laan, Meritxell Huch, Niels Geijsen, Robert G Vries, Hans Clevers, Jan Rothuizen, Baukje A Schotanus, Louis C Penning, Bart Spee
Jan 08, 2019
Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies...
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Michael Segel, Björn Neumann, Myfanwy FE Hill, Isabell P Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C Agley, Amelia J Thompson, Ginez A Gonzalez, Amar Sharma, Steffan Holmqvist, David H Rowitch, Kristian Franze, Robin Jm Franklin, Kevin J Chalut
Aug 21, 2019
Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells.
Bethan Lloyd-Lewis, Felicity M Davis, Olivia B Harris, Jessica R Hitchcock, Christine J Watson
Oct 10, 2018
Anja Füllgrabe, Simon Joost, Alexandra Are, Tina Jacob, Unnikrishnan Sivan, Andrea Haegebarth, Sten Linnarsson, Benjamin D Simons, Hans Clevers, Rune Toftgård, Maria Kasper
Dec 04, 2015
Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland.
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre
Aug 07, 2018
Adult stem cells Animals Cell Differentiation Cell Lineage Cell Plasticity Cell Transformation Neoplastic Epithelial Cells Female Fluorescent Antibody Technique Gene Expression Regulation Developmental Gestational Age Mammary Glands Animal Mice Mice Transgenic Models Genetic Morphogenesis Mouse embryonic stem cells Neoplastic Stem Cells Phenotype Receptor Notch1 Signal Transduction Single-Cell Analysis Time Factors
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.
Seungmin Han, Juergen Fink, David J Jörg, Eunmin Lee, Min Kyu Yum, Lemonia Chatzeli, Sebastian R Merker, Manon Josserand, Teodora Trendafilova, Amanda Andersson-Rolf, Catherine Dabrowska, Hyunki Kim, Ronald Naumann, Ji-Hyun Lee, Nobuo Sasaki, Richard Lester Mort, Onur Basak, Hans Clevers, Daniel E Stange, Anna Philpott, Jong Kyoung Kim, Benjamin D Simons, Bon-Kyoung Koo
Jul 24, 2019
Lgr5 Troy biophysical modeling deep tissue imaging gastric corpus isthmus stem cell Intestine punctuated neutral drift Single-cell RNA-seq two stem cell compartments unbiased genetic labeling Adult stem cells Biomarkers Cell Differentiation Cell Lineage Cell Self Renewal Cells Cultured Gastric Mucosa Humans Ki-67 Antigen Sequence Analysis RNA Single-Cell Analysis Stathmin Stem Cell Niche Stomach
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