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Results: 7
Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons.
Erika Harno, Charlotte Sefton, Jonathan R Wray, Tiffany-Jayne Allen, Alison Davies, Anthony P Coll, Anne White
Jun 08, 2021
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian YH Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A Malagon, Patricia Valerio, Marcos F Fondevila, Johan Fernø, Maria M Malagon, Raian Contreras, Paul Pfluger, Jens C Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Sep 10, 2018
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide...
Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice.
Charlotte Sefton, Alison Davies, Tiffany-Jayne Allen, Jonathan R Wray, Rosemary Shoop, Antony Adamson, Neil Humphreys, Anthony P Coll, Anne White, Erika Harno
Feb 27, 2019
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
UNLABELLED: The nucleus of the solitary tract (NTS) is emerging as a major site of action for the appetite-suppressive effects of leading pharmacotherapies currently investigated to treat obesity. However, our understanding of...
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
LK Burke, T Darwish, AR Cavanaugh, S Virtue, E Roth, J Morro, S-M Liu, J Xia, JW Dalley, K Burling, S Chua, T Vidal-Puig, GJ Schwartz, C Blouet
Jun 08, 2017
Generation and Characterization of Functional Human Hypothalamic Neurons.
POMC DIFFERENTIATION human Hypothalamus neuron obesity pluripotent stem cell Protocol Agouti-Related Protein Bone Morphogenetic Proteins Cell Culture Techniques Cell Differentiation Cells Cultured Enzyme Inhibitors Humans Hypothalamic Hormones Hypothalamus Neurogenesis Neurons Pluripotent Stem Cells Pro-Opiomelanocortin Signal Transduction Time Factors
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Arash Yavari, Claire J Stocker, Sahar Ghaffari, Edward T Wargent, Violetta Steeples, Gabor Czibik, Katalin Pinter, Mohamed Bellahcene, Angela Woods, Pablo B Martínez de Morentin, Céline Cansell, Brian YH Lam, André Chuster, Kasparas Petkevicius, Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Timothy J Pullen, Peter L Oliver, Alexander Stockenhuber, Chinh Nguyen, Merzaka Lazdam, Jacqueline F O'Dowd, Parvathy Harikumar, Mónika Tóth, Craig Beall, Theodosios Kyriakou, Julia Parnis, Dhruv Sarma, George Katritsis, Diana DJ Wortmann, Andrew R Harper, Laurence A Brown, Robin Willows, Silvia Gandra, Victor Poncio, Márcio J de Oliveira Figueiredo, Nathan R Qi, Stuart N Peirson, Rory J McCrimmon, Balázs Gereben, László Tretter, Csaba Fekete, Charles Redwood, Giles SH Yeo, Lora K Heisler, Guy A Rutter, Mark A Smith, Dominic J Withers, David Carling, Eduardo B Sternick, Jonathan RS Arch, Michael A Cawthorne, Hugh Watkins, Houman Ashrafian
Sep 03, 2019
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed...
AMP-Activated Protein Kinases Adiposity Adult aging Agouti-Related Protein Animals Arcuate Nucleus of Hypothalamus Energy Metabolism Enzyme Activation Feeding Behavior Female Heterozygote Humans Hyperphagia Hypothalamus Insulin Insulin-Secreting Cells Male Mice Mitochondria Mutation Neurons obesity Oxidative Phosphorylation Receptors Ghrelin Ribosomes Signal Transduction Transcriptome Up-Regulation