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The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier.
Jonathan J Ruprecht, Martin S King, Thomas Zögg, Antoniya A Aleksandrova, Els Pardon, Paul G Crichton, Jan Steyaert, Edmund RS Kunji
Jan 08, 2019
Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix-open states. The structure of the cytoplasmic-open state...
Adenine nucleotide translocase Adenine nucleotide translocator Alternating access mechanism Bioenergetics bongkrekate cardiolipin induced fit Mitochondria transport mechanism Adenosine Diphosphate Adenosine Triphosphate Amino Acid Sequence Binding Sites Biological Transport Bongkrekic Acid Cytoplasm Mitochondria Mitochondrial ADP ATP Translocases Mitochondrial Membrane Transport Proteins Models Molecular Protein Conformation Protein Structure Secondary Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism.
Uncoupling protein 1 (UCP1) is an integral membrane protein found in the mitochondrial inner membrane of brown adipose tissue, and facilitates the process of non-shivering thermogenesis in mammals. Its activation by fatty acids...
Alternating access mechanism Proton transport Purine nucleotide inhibition Thermogenesis Adipocytes Brown Adipose Tissue Brown Animals Cardiolipins Energy Metabolism Fatty Acids Gene Expression Regulation Humans Ion Transport Mitochondria Models Molecular Protons Purine Nucleotides Thermogenesis Uncoupling Protein 1