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Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production.
Andreas Giraud, Lynda Zeboudj, Marie Vandestienne, Jérémie Joffre, Bruno Esposito, Stéphane Potteaux, José Vilar, Daniela Cabuzu, Johannes Kluwe, Sylvie Seguier, Alain Tedgui, Ziad Mallat, Antoine Lafont, Hafid Ait-Oufella
Apr 09, 2019
AIMS: Abdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix destruction. Despite improvement...
abdominal aortic aneurysm Cell therapy Gingival fibroblasts Metalloproteases Remodelling Angiotensin II Animals Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Disease Models Animal Extracellular Matrix FIBROBLASTS Gingiva Mice Inbred C57BL Mice Knockout Protective Agents Tissue Inhibitor of Metalloproteinase-1 Transforming Growth Factor beta
Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.
Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms.
Marc Clément, Joel Chappell, Juliette Raffort, Fabien Lareyre, Marie Vandestienne, Annabel L Taylor, Alison Finigan, James Harrison, Martin R Bennett, Patrick Bruneval, Soraya Taleb, Helle F Jørgensen, Ziad Mallat
Mar 29, 2019
Objective- Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the...
Angiotensin II Autophagy clones Endoplasmic Reticulum Inflammation Mice Smooth muscle cells Adult Aged aortic dissection Angiotensin II Animals Aorta Aortic Aneurysm Autophagy Autophagy-Related Protein 5 Cell Lineage Cell Plasticity Cells Cultured Disease Models Animal Endoribonucleases Female Humans Male Mice 129 Strain Mice Inbred C57BL Mice Knockout ApoE Middle Aged Muscle Smooth Vascular Myocytes Smooth Muscle Phenotype Protein Serine-Threonine Kinases Signal Transduction
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.
Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud, Ludivine Laurans, Bruno Esposito, Florence Pinet, Patrick Bruneval, Juliette Raffort, Fabien Lareyre, Jose Vilar, Amir Boufenzer, Lea Guyonnet, Coralie Guerin, Eric Clauser, Jean-Sébastien Silvestre, Sylvie Lang, Laurie Soulat-Dufour, Alain Tedgui, Ziad Mallat, Soraya Taleb, Alexandre Boissonnas, Marc Derive, Giulia Chinetti, Hafid Ait-Oufella
Dec 07, 2020
The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the...
cell migration/adhesion Inflammation innate immunity Monocytes vascular biology Angiotensin II Animals Aortic Aneurysm Abdominal Cell Movement Gene Deletion Humans Interleukin-1beta Matrix Metalloproteinase 2 Mice Mice Knockout ApoE Monocytes Triggering Receptor Expressed on Myeloid Cells-1 Tumor Necrosis Factor-alpha
Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.
Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (KCNJ) 5 (KCNJ5) gene encoding the G-coupled...
GIRK4 K channel KCNJ5 gene RNASeq aldosterone knockout mice aldosterone Angiotensin II Animals Cell Line Tumor Cytochrome P-450 CYP11B2 Female G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression Profiling Humans Male Mice Inbred C57BL Mice Knockout Sex Factors Vasoconstrictor Agents zona glomerulosa
Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.
Padmapriya Ponnuswamy, Jeremie Joffre, Olivier Herbin, Bruno Esposito, Ludivine Laurans, Christoph J Binder, Thomas F Tedder, Lynda Zeboudj, Xavier Loyer, Andreas Giraud, Yujiao Zhang, Alain Tedgui, Ziad Mallat, Hafid Ait-Oufella
Jun 21, 2018
Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B...
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Ellie Paige, Marc Clément, Fabien Lareyre, Michael Sweeting, Juliette Raffort, Céline Grenier, Alison Finigan, James Harrison, James E Peters, Benjamin B Sun, Adam S Butterworth, Seamus C Harrison, Matthew J Bown, Jes S Lindholt, Stephen A Badger, Iftikhar J Kullo, Janet Powell, Paul E Norman, D Julian A Scott, Marc A Bailey, Stefan Rose-John, John Danesh, Daniel F Freitag, Dirk S Paul, Ziad Mallat
Feb 07, 2019
BACKGROUND: The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor ( IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known....
Alleles Aortic Aneurysm Genetics Inflammation Interleukins Alleles Angiotensin II Animals Antibodies Aortic Aneurysm Abdominal Biomarkers Disease Models Animal Humans Interleukin-6 Linear Models Mice Polymorphism Single Nucleotide Receptors Interleukin-6 Signal Transduction Survival Rate Transforming Growth Factor beta
Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension.
Silvana G Cooper, Lucas AC Souza, Caleb J Worker, Ariana Julia B Gayban, Sophie Buller, Ryosuke Satou, Yumei Feng Earley
Oct 24, 2022
The brain renin-angiotensin system plays important roles in blood pressure and cardiovascular regulation. There are two isoforms of prorenin in the brain: the classic secreted form (prorenin/sREN) encoded by renin-a, and an...
NAD(P)H oxidase angiotensin receptor autonomic control Renin-Angiotensin System salt-sensitive hypertension Angiotensin II Animals Cholinergic Agents Desoxycorticosterone Acetate Hypertension Mice NADPH Oxidase 2 RNA Messenger Renin Sodium Chloride sodium Dietary Subfornical Organ Tyrosine 3-Monooxygenase
Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.
Laura Davies, Jiawei Jin, Weijin Shen, Hoyee Tsui, Ying Shi, Yanwen Wang, Yanmin Zhang, Guoliang Hao, JingJing Wu, Si Chen, James A Fraser, Nianguo Dong, Vincent Christoffels, Ursula Ravens, Christopher L-H Huang, Henggui Zhang, Elizabeth J Cartwright, Xin Wang, Ming Lei
Oct 19, 2020
BACKGROUND: Atrial fibrillation (AF), often associated with structural, fibrotic change in cardiac tissues involving regulatory signaling mediators, becomes increasingly common with age. In the present study, we explored the...
aging Atrial fibrillation cardiac remodeling Age Factors Aged Angiotensin II Animals Atrial fibrillation Atrial Remodeling Case-Control Studies Cells Cultured Computer Simulation Down-Regulation Female Fibrosis Heart Rate Humans MAP Kinase Kinase 4 Male Mice Mice Knockout Myocytes Cardiac Rats Rats Sprague-Dawley Signal Transduction Transfection Transforming Growth Factor beta1
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
Sarvenaz Metghalchi, Marie Vandestienne, Yacine Haddad, Bruno Esposito, Julien Dairou, Alain Tedgui, Ziad Mallat, Stephane Potteaux, Soraya Taleb
Jun 21, 2018
AIMS: Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix degradation. Despite considerable progress in...