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Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1.
James M Dunce, Amy E Milburn, Manickam Gurusaran, Irene da Cruz, Lee T Sen, Ricardo Benavente, Owen R Davies
Mar 02, 2020
Meiotic chromosomes undergo rapid prophase movements, which are thought to facilitate the formation of inter-homologue recombination intermediates that underlie synapsis, crossing over and segregation. The meiotic telomere...
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.
IDP biophysics coupled folding and binding Electrostatics Kinetics phi-value protein dynamic protein electrostatics Protein Folding protein-protein interactions residual structure signaling Apoptosis Regulatory Proteins CREB-Binding Protein Cyclic AMP Response Element-Binding Protein Humans Hydrophobic and Hydrophilic Interactions Intrinsically Disordered Proteins Kinetics Molecular Dynamics Simulation Myeloid Cell Leukemia Sequence 1 Protein Protein Binding Protein Folding Protein Interaction Domains and Motifs Proto-Oncogene Proteins Signal Transduction Static Electricity Thermodynamics
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
Jason D Cooper, Deborah J Smyth, Rebecca Bailey, Felicity Payne, Kate Downes, Lisa M Godfrey, Jennifer Masters, Lauren R Zeitels, Adrian Vella, Neil M Walker, John A Todd
Jun 16, 2011
Antigens CD Apoptosis Regulatory Proteins Case-Control Studies Diabetes mellitus Type 1 Genetic Markers Genetic Predisposition to Disease Genotype Humans Intercellular Adhesion Molecule-1 Interleukin-6 Logistic Models Polymorphism Single Nucleotide Programmed Cell Death 1 Receptor T Cell Transcription Factor 1 TATA-Binding Protein Associated Factors Transcription Factor TFIID
Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.
Si Ming Man, Andrew Ekpenyong, Panagiotis Tourlomousis, Sarra Achouri, Eugenia Cammarota, Katherine Hughes, Alessandro Rizzo, Gilbert Ng, John A Wright, Pietro Cicuta, Jochen R Guck, Clare E Bryant
Feb 03, 2015
ASC ROS caspase-1 Cytoskeleton innate immunity Actin Cytoskeleton Actins Animals Apoptosis Regulatory Proteins Bone Marrow Cells Calcium-Binding Proteins Caspase 1 Cytoskeleton Hydrogen Peroxide Immunity Innate Inflammasomes Inflammation Interleukin-1beta MACROPHAGES Mice Mice Transgenic Microscopy Confocal Neutrophils Polymerization Reactive Oxygen Species Salmonella Infections Salmonella typhimurium
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Hongjun Fu, Andrea Possenti, Rosie Freer, Yoshikazu Nakano, Nancy C Hernandez Villegas, Maoping Tang, Paula VM Cauhy, Benjamin A Lassus, Shuo Chen, Stephanie L Fowler, Helen Y Figueroa, Edward D Huey, Gail Vw Johnson, Michele Vendruscolo, Karen E Duff
Jul 26, 2019
Excitatory neurons are preferentially impaired in early Alzheimer's disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place...
Complex inhibitory effects of nitric oxide on autophagy.
Sovan Sarkar, Viktor I Korolchuk, Maurizio Renna, Sara Imarisio, Angeleen Fleming, Andrea Williams, Moises Garcia-Arencibia, Claudia Rose, Shouqing Luo, Benjamin R Underwood, Guido Kroemer, Cahir J O'Kane, David C Rubinsztein
Jan 04, 2018
Autophagy, a major degradation process for long-lived and aggregate-prone proteins, affects various human processes, such as development, immunity, cancer, and neurodegeneration. Several autophagy regulators have been identified...
Animals Apoptosis Regulatory Proteins Autophagy Beclin-1 Cell Line Class III Phosphatidylinositol 3-Kinases Enzyme Inhibitors HEK293 Cells HeLa Cells Humans Huntingtin Protein Huntington Disease I-kappa B Kinase Mechanistic Target of Rapamycin Complex 1 Membrane Proteins Mice Mitogen-Activated Protein Kinase 8 Multiprotein Complexes NG-Nitroarginine Methyl Ester Nerve Tissue Proteins Nitric oxide nitric oxide synthase Nuclear Proteins Phosphorylation Protein Isoforms Proteins Proto-Oncogene Proteins c-bcl-2 Rats TOR Serine-Threonine Kinases Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins
Role of Non-Native Electrostatic Interactions in the Coupled Folding and Binding of PUMA with Mcl-1
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.
Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher, Farida Latif
Jun 13, 2011
Amino Acid Sequence Apoptosis Regulatory Proteins Cell Line Tumor CpG Islands DNA Methylation Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Molecular Sequence Data Monomeric GTP-Binding Proteins Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma Sequence Alignment
XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation.
Fang Lin, Ghita Ghislat, Shouqing Luo, Maurizio Renna, Farah Siddiqi, David C Rubinsztein
May 05, 2015
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M Lindgren, Jian'an Luan, Luca A Lotta, Claudia Langenberg, Peter Arner, Rona J Strawbridge, Ingrid Dahlman
Apr 01, 2020
OBJECTIVES: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes. The goal of this...
Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.
Hanne Dubois, Frederic Sorgeloos, Soroush T Sarvestani, Liesbet Martens, Yvan Saeys, Jason M Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert
Mar 25, 2019
Animals Apoptosis Regulatory Proteins Caliciviridae Infections Cells Cultured Gastrointestinal Tract Inflammasomes Interleukin-1beta Intracellular Signaling Peptides and Proteins MACROPHAGES Mice Mice Inbred C57BL Mice Knockout NLR Family Pyrin Domain-Containing 3 Protein Norovirus Phosphate-Binding Proteins pyroptosis STAT1 Transcription Factor
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Majid Sakhi Jabir, Lee Hopkins, Neil D Ritchie, Ihsan Ullah, Hannah K Bayes, Dong Li, Panagiotis Tourlomousis, Alison Lupton, Daniel Puleston, Anna Katharina Simon, Clare Bryant, Thomas J Evans
Jul 16, 2018
The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated through the microbial type III...
AIM2 absent in melanoma 2 ATG autophagy related ATPIF1 ATPase inhibitory factor 1 BID BH3 interacting domain death agonist BMDM bone marrow-derived macrophages BrdU 5-bromo-2-deoxyuridine CASP caspase DNA detection GFP green fluorescent protein IL1B interleukin 1 β LC3B microtubule-associated protein 1 light chain 3 β LDH lactate dehydrogenase LPS lipopolysaccharide MT-CO1 mitochondrially encoded cytochrome c oxidase I Mito-TEMPO (2-(2 2 6 6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride NAc N-acetylcysteine NAIP NLR family apoptosis inhibitor NGS normal goat serum NLR proteins NLR nucleotide-binding domain leucine-rich repeat containing NLRC4 NLR family CARD domain containing 4 NLRP3 NLR family pyrin domain containing 3 PBS phosphate-buffered saline PINK1 PTEN induced putative kinase 1 Rn18s 18S rRNA T3SS type III secretion system TNF Tumor Necrosis Factor TUBB5 tubulin β 5 class I Three-MA 3-methyladenine Vav vav 1 oncogene Infection mitophagy mtDNA mitochondrial DNA type III secretion system Animals Apoptosis Regulatory Proteins Autophagy Bone Marrow Cells Calcium-Binding Proteins DNA Mitochondrial DNA-Binding Proteins Down-Regulation Female HEK293 Cells Humans Inflammasomes MACROPHAGES Mice Inbred C57BL Mitochondria mitophagy Protein Binding Pseudomonas Infections Pseudomonas aeruginosa Reactive Oxygen Species
Prediction of GABARAP interaction with the GABA type A receptor.
We have performed docking simulations on GABARAP interacting with the GABA type A receptor using SwarmDock. We have also used a novel method to study hydration sites on the surface of these two proteins; this method identifies...
GABA receptor associated protein changes the electrostatic environment around the GABA type A receptor.
Benedict WJ Irwin, Clara C Wanjura, Daniel Molnar, Michael J Rutter, Michael C Payne, P-L Chau
Oct 04, 2021
NLRP3 inflammasome pathways in atherosclerosis.
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns...
Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.
Parimal Kumar, Trevor R Sweeney, Maxim A Skabkin, Olga V Skabkina, Christopher UT Hellen, Tatyana V Pestova
Feb 17, 2020
Ribosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA's 5'-terminal 'cap'. The minimal 'cap0' consists of N7-methylguanosine linked to the first nucleotide via a 5'-5' triphosphate (ppp) bridge. Cap0 is...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Binding Competitive Carrier Proteins Eukaryotic Initiation Factor-4E Eukaryotic Initiation Factor-4F Intracellular Signaling Peptides and Proteins Neoplasm Proteins Peptide Chain Initiation Translational Proteins RNA Caps RNA Transfer RNA-Binding Proteins Recombinant Proteins Ribosomes
Promiscuous and Selective
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.
Tissue expression microarrays, employed to determine the players and mechanisms leading to prostate cancer development, have consistently shown that myosin VI, a unique actin-based motor, is upregulated in medium-grade human...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Blotting Western Cell Line Cell Line Tumor Endocytosis Endosomes Gene Expression Golgi Apparatus Green Fluorescent Proteins HeLa Cells Humans Male Membrane Proteins Microscopy Fluorescence Microscopy Immunoelectron Myosin Heavy Chains Prostate-specific antigen Prostatic Neoplasms Protein Binding Protein Serine-Threonine Kinases RNA Interference Recombinant Fusion Proteins Transfection Tumor Suppressor Proteins Vascular Endothelial Growth Factor A
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G Aragam, Johan Ärnlöv, Joshua D Backman, Mary L Biggs, Heather L Bloom, Jeffrey Brandimarto, Michael R Brown, Leonard Buckbinder, David J Carey, Daniel I Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P Cook, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Michael E Dunn, Gunnar Engström, Tõnu Esko, Stephan B Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Craig L Hyde, Erik Ingelsson, J Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B Margulies, Winfried März, Olle Melander, Ify R Mordi, Thomas Morgan, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Alexander Niessner, Teemu Niiranen, Michelle L O'Donoghue, Anjali T Owens, Colin NA Palmer, Helen M Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M Psaty, Regeneron Genetics Center, Kenneth M Rice, Paul M Ridker, Simon PR Romaine, Jerome I Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Steen Stender, David J Stott, Per Svensson, Mari-Liis Tammesoo, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Dawn Waterworth, Peter E Weeke, Raul Weiss, Kerri L Wiggins, Heming Xing, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J Samani, John JV McMurray, Jian Yang, Peter M Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A Lubitz, Naveed Sattar, Michael V Holmes, Thomas P Cappola, Folkert W Asselbergs, Aroon D Hingorani, Karoline Kuchenbaecker, Patrick T Ellinor, Chim C Lang, Kari Stefansson, J Gustav Smith, Ramachandran S Vasan, Daniel I Swerdlow, R Thomas Lumbers
Jan 29, 2020
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Atrial fibrillation Cardiomyopathies Carrier Proteins Case-Control Studies Coronary Artery Disease Cyclin-Dependent Kinase Inhibitor p21 Genome-Wide Association Study Heart Failure Humans Mendelian Randomization Analysis Microfilament Proteins Muscle Proteins Risk Factors Ventricular Function Left
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.
Andrew S Cowburn, Charlotte Summers, Benjamin J Dunmore, Neda Farahi, Richard P Hayhoe, Cristin G Print, Simon J Cook, Edwin R Chilvers
Jun 19, 2018
Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis...
Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Caspase 9 Cell Survival Gene Expression Regulation Granulocyte Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Inflammation Membrane Proteins Microscopy Confocal Models Biological Neutrophils Phenotype Pneumonia Proto-Oncogene Proteins Tumor Necrosis Factor-alpha
The fifth adaptor protein complex.
Jennifer Hirst, Lael D Barlow, Gabriel Casey Francisco, Daniela A Sahlender, Matthew NJ Seaman, Joel B Dacks, Margaret S Robinson
Jan 24, 2018
Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the...
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.
Si Ming Man, Lee J Hopkins, Eileen Nugent, Susan Cox, Ivo M Glück, Panagiotis Tourlomousis, John A Wright, Pietro Cicuta, Tom P Monie, Clare E Bryant
May 08, 2014
ASC Bacteria caspase-1 caspase-8 innate immunity Animals Apoptosis Apoptosis Regulatory Proteins Bone Marrow Cells Calcium-Binding Proteins Carrier Proteins Caspase 1 Caspase 8 Enzyme Activation HEK293 Cells Humans Inflammasomes Inflammation Interleukin-1beta MACROPHAGES Mice Mice Transgenic NLR Family Pyrin Domain-Containing 3 Protein Salmonella typhimurium
Altered expression of cell cycle and apoptotic proteins in chronic hepatitis C virus infection.
Saira Sarfraz, Saeed Hamid, Anwar Siddiqui, Snawar Hussain, Shahid Pervez, Graeme Alexander
Jun 14, 2011
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