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C. elegans Piwi RNA processing RNAi epigenetic inheritance nuclear RNAi piRNA splicing Transcription transposable elements Animals Argonaute Proteins Caenorhabditis elegans Caenorhabditis elegans Proteins DNA Transposable Elements Introns Nuclear Proteins Protein Binding RNA Interference

Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how the...

Animals Argonaute Proteins Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Cytoplasmic Granules Gene Silencing Germ Cells Mutation Protein Binding Proteomics RNA Interference RNA Double-Stranded RNA Small Interfering

In mice, the pathway involving PIWI and PIWI-interacting RNA (PIWI-piRNA) is essential to re-establish transposon silencing during male-germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon...

Animals Argonaute Proteins Gene Expression Regulation Mice Mice Knockout RNA Small Interfering

chromosome inversions flamenco Fruit fly Gene Silencing Germ Cells gypsy12 Heterochromatin POSITION-EFFECT VARIEGATION sterility transposable elements Animals Animals Genetically Modified Argonaute Proteins Chromosome Deletion Chromosomes Insect DNA Transposable Elements Drosophila Proteins Drosophila melanogaster evolution Molecular Female Fertility Gene Expression Regulation Developmental Multigene Family Ovary RNA Stability RNA Small Interfering

The unicellular green alga Chlamydomonas reinhardtii is evolutionarily divergent from higher plants, but has a fully functional silencing machinery including microRNA (miRNA)-mediated translation repression and mRNA turnover....

3' Untranslated Regions Argonaute Proteins Biological Evolution Chlamydomonas reinhardtii Gene Expression Gene Expression Regulation Plant MicroRNAs Phylogeny RNA Interference RNA Messenger RNA Small Interfering

Arabidopsis Arabidopsis Proteins Argonaute Proteins Cucumovirus Methyltransferases Plant Diseases Viral Proteins

Argonaute Proteins Breast Neoplasms DEAD-box RNA Helicases DNA Primers Endoribonucleases Eukaryotic Initiation Factor-2 Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation Humans Mammary Glands Human MicroRNAs RNA Messenger Ribonuclease III

Hippo Piwi Ras Warts piRNA transposon Animals Argonaute Proteins Cell Line Cell Proliferation Cell Transformation Neoplastic Cells Cultured DNA Transposable Elements Drosophila Drosophila Proteins Female Gene Expression Regulation Gene Silencing Ovary RNA Small Interfering Signal Transduction

Animals Argonaute Proteins DNA Transposable Elements Embryonic Stem Cells Female Gene Expression Profiling Gene Expression Regulation Developmental Germ Cells Infertility female Meiosis Mice MicroRNAs Oocytes RNA Small Interfering

The process of erythropoiesis must be efficient and robust to supply the organism with red bloods cells both under condition of homeostasis and stress. The microRNA (miRNA) pathway was recently shown to regulate erythroid...

Anemia Animals Argonaute Proteins Cell Differentiation Cell Lineage Erythroblasts Erythroid Cells Erythropoiesis Eukaryotic Initiation Factor-2 Gene Expression Regulation Developmental Genetic Loci Homeostasis Hyperplasia Mice Mice Inbred C57BL MicroRNAs

Argonaute Proteins Cell Cycle GTP-Binding Protein gamma Subunits Humans Oligonucleotide Array Sequence Analysis Protein Isoforms RNA Interference RNA Polymerase III RNA Long Noncoding rho GTP-Binding Proteins

PIWI-interacting RNAs (piRNAs) and their partnering PIWI proteins defend the animal germline against transposable elements and play a crucial role in fertility. Numerous studies in the past have uncovered many additional...

Animals Argonaute Proteins Cluster Analysis DNA Transposable Elements Databases Genetic Datasets as Topic evolution Molecular Genetic Loci Genome Humans Internet Phylogeny RNA Small Interfering Software

The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. piRNAs are proposed to recruit MIWI2 to the transcriptionally...

Animals Argonaute Proteins Cell Cycle Proteins DNA Methylation DNA Transposable Elements Female Fetus Gene Silencing Genome Germ Cells Male Mice Mice Inbred C57BL Protein Binding Testis

BACKGROUND: MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells...

Animals Argonaute Proteins Cell Differentiation Cell Proliferation Cells Cultured DEAD-box RNA Helicases DNA Methylation Endoribonucleases Eukaryotic Initiation Factor-2 Female Gene Expression Regulation Germ Cells Inhibitor of Apoptosis Proteins Integrases Long Interspersed Nucleotide Elements Male Mice Mice Knockout MicroRNAs RNA Small Interfering Ribonuclease III Spermatogenesis Testis Ubiquitin-Protein Ligases

Nuclear RNA interference (RNAi) pathways work together with histone modifications to regulate gene expression and enact an adaptive response to transposable RNA elements. In the germline, nuclear RNAi can lead to...

22G-RNA Argonaute NRDE-3 RNA Interference RNAi piRNA trans-generational epigenetic inheritance Animals Argonaute Proteins Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Nucleus Gene Silencing Germ Cells Nuclear Proteins RNA Interference RNA Double-Stranded RNA Nuclear RNA Small Interfering RNA-Binding Proteins

ALCL ALK kinase IL-10 IL-21 IL-22 Cytokines miR-155 Anaplastic Lymphoma Kinase Animals Argonaute Proteins CCAAT-Enhancer-Binding Protein-beta Case-Control Studies Caspase 3 Cell Line Tumor Chromosomes Human Pair 2 Chromosomes Human Pair 5 DNA Methylation Gene Expression Regulation Neoplastic Genetic Therapy Humans Lymphoma Large-Cell Anaplastic Mice Inbred NOD Mice SCID MicroRNAs Promoter Regions Genetic Receptor Protein-Tyrosine Kinases STAT3 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Transfection Translocation Genetic Xenograft Model Antitumor Assays

Defective germline reprogramming in Piwil4 (Miwi2)- and Dnmt3l-deficient mice results in the failure to reestablish transposon silencing, meiotic arrest and progressive loss of spermatogonia. Here we sought to understand the...

Animals Argonaute Proteins Cells Cultured Cellular Reprogramming DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Transposable Elements Genes Intracisternal A-Particle Male Meiosis Mice Mice Inbred C57BL Mice Knockout Spermatogonia Transcriptome

The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects the genetic information of animal germ cells from the deleterious effects of molecular parasites, such as transposons. Discovered nearly a...

PIWI proteins piRNA biogenesis ping-pong amplification loop post-transcriptional gene silencing (PTGS) transcriptional gene silencing (TGS) transposon control Animals Argonaute Proteins Chromosomal Proteins Non-Histone Drosophila Proteins Drosophila melanogaster Gene Silencing Histones Humans Microtubule-Associated Proteins RNA Messenger RNA Small Interfering RNA-Binding Proteins Transcription Genetic