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The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology.
Thomas E Wood, Sophie A Howard, Andreas Förster, Laura M Nolan, Eleni Manoli, Nathan P Bullen, Hamish CL Yau, Abderrahman Hachani, Richard D Hayward, John C Whitney, Waldemar Vollmer, Paul S Freemont, Alain Filloux
Jul 13, 2020
The type VI secretion system (T6SS) is crucial in interbacterial competition and is a virulence determinant of many Gram-negative bacteria. Several T6SS effectors are covalently fused to secreted T6SS structural components such...
Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa.
Ian J Passmore, Kahoko Nishikawa, Kathryn S Lilley, Steven D Bowden, Jade CS Chung, Martin Welch
Feb 16, 2015
The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella.
David M Bulmer, Lubna Kharraz, Andrew J Grant, Paul Dean, Fiona JE Morgan, Michail H Karavolos, Anne C Doble, Emma J McGhie, Vassilis Koronakis, Richard A Daniel, Pietro Mastroeni, CM Anjam Khan
Mar 19, 2019
Although there have been great advances in our understanding of the bacterial cytoskeleton, major gaps remain in our knowledge of its importance to virulence. In this study we have explored the contribution of the bacterial...
Identity Determinants of the Translocation Signal for a Type 1 Secretion System
The toxin hemolysin A was first identified in uropathogenic E. coli strains and shown to be secreted in a one-step mechanism by a dedicated secretion machinery. This machinery, which belongs to...
Olivia Spitz, Isabelle N Erenburg, Kerstin Kanonenberg, Sandra Peherstorfer, Michael HH Lenders, Jens Reiners, Miao Ma, Ben F Luisi, Sander HJ Smits, Lutz Schmitt
Feb 24, 2022
More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells.
Laura Gomez-Valero, Christophe Rusniok, Danielle Carson, Sonia Mondino, Ana Elena Pérez-Cobas, Monica Rolando, Shivani Pasricha, Sandra Reuter, Jasmin Demirtas, Johannes Crumbach, Stephane Descorps-Declere, Elizabeth L Hartland, Sophie Jarraud, Gordon Dougan, Gunnar N Schroeder, Gad Frankel, Carmen Buchrieser
Feb 18, 2019
The genus Legionella comprises 65 species, among which Legionella pneumophila is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally...