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X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is achieved by the early blastocyst...

Animals Blastocyst Inner Cell Mass Epigenesis Genetic Female Genes X-Linked Histones In Situ Hybridization Fluorescence Male Mice Mice Inbred C57BL Mice Inbred DBA Models Genetic Pregnancy RNA Long Noncoding Sequence Analysis RNA Single-Cell Analysis Transcription Factors X Chromosome Inactivation

cell identity transitions Pluripotency reprogramming signaling transcriptional networks Animals Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Plasticity Cellular Reprogramming Female Gene Expression Regulation Developmental Gene Regulatory Networks Germ Layers Mice Mice Inbred C57BL Octamer Transcription Factor-3 Pluripotent Stem Cells Signal Transduction

OCT4 STAT3 pathway developmental biology metabolism single-cell profiling Animals Blastocyst Inner Cell Mass Cell Lineage Embryo Mammalian Embryonic Development Gene Expression Regulation Developmental Glycolysis Mice Octamer Transcription Factor-3 Pluripotent Stem Cells STAT3 Transcription Factor Signal Transduction Single-Cell Analysis

Biopsy Blastocyst Inner Cell Mass Female Genome Human Humans Mesoderm Mosaicism Mutagenesis Mutation Mutation Rate Placenta Pregnancy Trisomy Trophoblasts Zygote

During pre-implantation development, the mammalian embryo self-organizes into the blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) giving rise to all embryonic tissues. In mice, oriented...

Adaptor Proteins Signal Transducing Animals Blastocyst Blastocyst Inner Cell Mass Blastomeres Cell Cycle Proteins Cell Differentiation Cell Division Cell Lineage Cell Movement Cell Polarity Embryo Mammalian Embryonic Development Female Male Mice Phosphoproteins Protein Transport Reproducibility of Results YAP-Signaling Proteins

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows...

Animals Biomarkers Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Lineage Cell Proliferation Clone Cells Embryo Culture Techniques Embryo Implantation Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Gestational Age Laminin Mice Mice 129 Strain Mice Inbred C57BL Mice Inbred CBA Phenotype Pluripotent Stem Cells Transcription Factors

Embryo human Pluripotency RNA-seq single cell Animals Blastocyst Blastocyst Inner Cell Mass Cell Line Cell Lineage Chromosome Mapping Embryo Culture Techniques Embryonic Development Gene Expression Profiling Genetic Markers Germ Layers Humans Pluripotent Stem Cells Primates Single-Cell Analysis