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BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
Sarah JL Graham, Krzysztof B Wicher, Agnieszka Jedrusik, Guoji Guo, Wishva Herath, Paul Robson, Magdalena Zernicka-Goetz
Oct 20, 2014
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.
Joep Beumer, Benedetta Artegiani, Yorick Post, Frank Reimann, Fiona Gribble, Thuc Nghi Nguyen, Hongkui Zeng, Maaike Van den Born, Johan H van Es, Hans Clevers
Oct 19, 2018
Enteroendocrine cells (EECs) control a wide range of physiological processes linked to metabolism1. We show that EEC hormones are differentially expressed between crypts (for example, Glp1) and villi (for example, secretin). As...
Bone morphogenetic protein 4 (BMP4) loss-of-function variant associated with autosomal dominant Stickler syndrome and renal dysplasia.
Thomas RW Nixon, Allan Richards, Laura K Towns, Gavin Fuller, Stephen Abbs, Philip Alexander, Annie McNinch, Richard N Sandford, Martin P Snead
Dec 03, 2020
Stickler syndrome is a genetic disorder that can lead to joint problems, hearing difficulties and retinal detachment. Genes encoding collagen types II, IX and XI are usually responsible, but some families have no causal variant...
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
Miguel L Soares, Seiki Haraguchi, Maria-Elena Torres-Padilla, Tibor Kalmar, Lee Carpenter, Graham Bell, Alastair Morrison, Christopher JA Ring, Neil J Clarke, David M Glover, Magdalena Zernicka-Goetz
Jun 16, 2011
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Kazuhiro Murakami, Ufuk Günesdogan, Jan J Zylicz, Walfred WC Tang, Roopsha Sengupta, Toshihiro Kobayashi, Shinseog Kim, Richard Butler, Sabine Dietmann, M Azim Surani
Dec 09, 2015
Activins Animals Bone Morphogenetic Protein 4 Cell Differentiation Chromatin DNA-Binding Proteins Enhancer Elements Genetic Epigenesis Genetic Female Fibroblast Growth Factor 2 Gene Expression Regulation Developmental Genome Germ Cells Germ Layers Homeodomain Proteins Male Mice Mouse embryonic stem cells Nanog Homeobox Protein Pluripotent Stem Cells Positive Regulatory Domain I-Binding Factor 1 Protein Binding RNA-Binding Proteins SOXB1 Transcription Factors Transcription Factor AP-2 Transcription Factors
Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media.
Baojiang Wu, Lin Li, Bojiang Li, Junpeng Gao, Yanglin Chen, Mengyi Wei, Zhiqing Yang, Baojing Zhang, Shudong Li, Kexin Li, Changshan Wang, M Azim Surani, Xihe Li, Fuchou Tang, Siqin Bao
Feb 04, 2020
Inhibitors of Mek1/2 and Gsk3β, known as 2i, and, together with leukemia inhibitory factor, enhance the derivation of embryonic stem cells (ESCs) and promote ground-state pluripotency (2i/L-ESCs). However, recent reports show...
Blastocyst Chemically Defined development Embryonic Stem Cells epigenetics Genomic Imprinting hypermethylation Implantation MOUSE Pluripotency Activins Animals Blastocyst Bone Morphogenetic Protein 4 Cell Self Renewal Culture Media Serum-Free DNA Methylation Epigenesis Genetic Genomic Instability Mice Mitogen-Activated Protein Kinase Kinases Mouse embryonic stem cells Pluripotent Stem Cells Protein Kinase Inhibitors Signal Transduction Up-Regulation