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Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
Md Saiful Islam, Michael A McDonough, Rasheduzzaman Chowdhury, Joseph Gault, Amjad Khan, Elisabete Pires, Christopher J Schofield
Jun 26, 2020
2-oxoglutarate and iron dependent dioxygenase C-5 hydroxylysine JMJD6 JmjC domain-containing protein 6 RNA Splicing X-ray crystallography dioxygenase enzyme catalysis enzyme structure hydroxylase hydroxylysine (Hyl) Hypoxia metalloenzyme Substrate Specificity Catalysis Crystallography X-Ray Estrogen Receptor alpha Humans Hydroxylation Jumonji Domain-Containing Histone Demethylases Kinetics Lysine Protein Conformation Substrate Specificity