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The spread of multi-drug resistance and the slow pace at which antibiotics come onto the market are undermining our ability to treat human infections, leading to high mortality rates. Aiming to overcome this global crisis...

Amino Acid Sequence Animals Antimicrobial Cationic Peptides Caco-2 Cells Cathelicidins Cell Survival Cell Wall Escherichia coli Humans Hydrogen Bonding Larva Lipid Bilayers Molecular Dynamics Simulation Moths Protein Conformation alpha-Helical Static Electricity

NAMPT may represent a novel target for drug discovery in various therapeutic areas, including oncology and inflammation. Additionally, recent work has suggested that targeting NAMPT has potential in treating axon degeneration....

axon degeneration Molecular docking NAMPT Similarity searching Virtual screening Animals Antineoplastic Agents Axons Caco-2 Cells Cell Line Tumor Cell Proliferation Crystallography X-Ray Cytochrome P-450 Enzyme System Cytokines Dose-Response Relationship Drug Drug Discovery Drug Screening Assays Antitumor Enzyme Inhibitors Humans Mice Mice Nude Models Molecular Molecular Structure Nicotinamide Phosphoribosyltransferase Structure-Activity Relationship

Animals Caco-2 Cells Computer Graphics Cyprinidae Databases Pharmaceutical Drug Design Drug-Related Side Effects and Adverse Reactions Humans Models Theoretical Pharmacokinetics Rats Small Molecule Libraries Software Tetrahymena pyriformis Toxicity Tests User-Computer Interface

Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies...

Atomic force microscopy cell stiffness epithelial ion transport fluoride gastrointestinal epithelia Proteomics Animals Caco-2 Cells Cell Adhesion Chlorides Elastic Modulus Fluorides Humans Intestinal Mucosa Mice Microscopy Atomic Force Microscopy Electron Scanning Microscopy Fluorescence Patch-Clamp Techniques Proteome Rats

Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by...

Animals Bacterial Toxins Caco-2 Cells Cell Line Tumor Cells Cultured Cellular Senescence DNA Damage DNA Replication DNA Single-Stranded Histones Humans Mice Neoplasms RAW 264.7 Cells Replication Protein A salmonella

BACKGROUND & AIMS: Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER...

Gene Expression IBD Inflammation Signal Transduction Activating Transcription Factor 6 Animals Autophagy Caco-2 Cells Cell Culture Techniques Endoplasmic Reticulum Chaperone BiP Endoplasmic reticulum stress Epithelial Cells HEK293 Cells Humans Ileum Inflammatory Bowel Diseases Intestinal Mucosa Mice Signal Transduction

calicivirus carbon metabolism Glycolysis noroviruses Oxidative Phosphorylation pentose phosphate pathway Animals Caco-2 Cells Caliciviridae Infections Glycolysis Host-Pathogen Interactions Humans MACROPHAGES Metabolomics Mice Norovirus Oxidative Phosphorylation pentose phosphate pathway RAW 264.7 Cells Virus Replication

A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-22 is a barrier protective cytokine by inducing...

Animals Autophagy-Related Proteins Caco-2 Cells Carrier Proteins genetic variation Humans Inflammatory Bowel Diseases Interleukins Intestinal Mucosa Membrane Proteins Mice Mice Knockout Nucleotidyltransferases Signal Transduction

Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have been reported in humans. One...

Animals Astroviridae Infections Caco-2 Cells Cell Line Chlorocebus aethiops Enterocytes Gastroenteritis Humans Immunity Innate Interferons Intestinal Mucosa Intestine Small Mamastrovirus Vero Cells Viral Tropism

Caco-2 Cells Disease Outbreaks genetic variation Genomic Islands Genomics Humans Phenotype Plasmids Prophages Salmonella Infections Salmonella enteritidis Uruguay

The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea. Although 22 antigenically different colonization factors (CFs) have been identified and characterized in...

Animals Caco-2 Cells Diarrhea Enterotoxigenic Escherichia coli Escherichia coli Infections Fimbriae Proteins Humans Intestine Small Microscopy Electron Phenotype Swine whole genome sequencing

Sophorolipids (SL) are amphiphilic biosurfactant molecules consisting of a disaccharide sophorose with one fatty acid at the C1 position and optional acetylation at the C6'and C6" positions. They exist in a closed ring lactonic...

Animals Ascomycota Caco-2 Cells Cell Extracts Cell Line Tumor Cell Proliferation Colorectal Neoplasms Female Genes APC Glycolipids HCT116 Cells HT29 Cells Humans Male Mice Mice Transgenic Tumor Burden Up-Regulation

Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to the global well-being of their host. A wide variety of metabolites produced by commensal bacteria are...

IDO-1 butyrate Gut microbiota immune gene regulation intestinal epithelial cells Bacteria Butyric Acid Caco-2 Cells Down-Regulation Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Regulation Developmental Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Interferon-gamma Intestinal Mucosa Male Middle Aged Receptors G-Protein-Coupled Transcription Factors

7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive...

7-methylguanosine G-Quadruplexes METTL1 RNA methylation SAM-dependent methyltransferase cell migration high-throughput sequencing let-7 miRNA biogenesis microRNA A549 Cells Base Sequence Biological Assay Caco-2 Cells Cell Movement Cell Proliferation Guanosine HEK293 Cells Humans Methylation Methyltransferases MicroRNAs Nucleic Acid Conformation RNA processing Post-Transcriptional

Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome...

Adolescent Adult Age Factors Aged Aged 80 and over Asymptomatic Infections covid-19 COVID-19 Nucleic Acid Testing Caco-2 Cells Child Child Preschool Female Germany Hospitalization Humans Infant Male Middle Aged Probability SARS-CoV-2 Viral Load Virus Replication Virus Shedding Young Adult