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Results: 200
IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
Peace Atakpa, Nagendra Babu Thillaiappan, Stefania Mataragka, David L Prole, Colin W Taylor
Dec 21, 2018
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistribute Ca2+ from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H+-ATPase (V-ATPase)...
Ca(2+) IP(3) receptor concanamycin A Endoplasmic Reticulum genetically encoded Ca(2+) sensor lysosome membrane contact site proximity ligation assay store-operated Ca(2+) entry Calcium Calcium Signaling Cytosol Endoplasmic Reticulum HEK293 Cells HeLa Cells Humans Hydrogen-Ion Concentration Inositol 1 4 5-Trisphosphate Receptors Lysosomes
Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome.
Mallory C Shields, Matthew R Bowers, McKenzie M Fulcer, Madelyn K Bollig, Patrick J Rock, Bryan R Sutton, Alysia D Vrailas-Mortimer, Hanns Lochmüller, Roger G Whittaker, Rita Horvath, Noreen E Reist
Mar 07, 2019
During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human...
Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia.
5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.
Tereza Bautzova, James RF Hockley, Teresa Perez-Berezo, Julien Pujo, Michael M Tranter, Cleo Desormeaux, Maria Raffaella Barbaro, Lilian Basso, Pauline Le Faouder, Corinne Rolland, Pascale Malapert, Aziz Moqrich, Helene Eutamene, Alexandre Denadai-Souza, Nathalie Vergnolle, Ewan St John Smith, David I Hughes, Giovanni Barbara, Gilles Dietrich, David C Bulmer, Nicolas Cenac
Jan 04, 2019
Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies.
Calmodulin sits at the center of molecular mechanisms underlying learning and memory. Its complex and sometimes opposite influences, mediated via the binding to various proteins, are yet to be fully understood....
DORN1/P2K1 and purino-calcium signalling in plants
Elsa Matthus, Jian Sun, Limin Wang, Madhura G Bhat, Amirah B Mohammad-Sidik, Katie A Wilkins, Nathalie Leblanc-Fournier, Valérie Legué, Bruno Moulia, Gary Stacey, Julia M Davies
Feb 06, 2020
BACKGROUND AND AIMS:Extracellular ATP governs a range of plant functions, including cell viability, adaptation and cross-kingdom interactions. Key functions of extracellular ATP in leaves and roots may involve an increase in...
Published by: Annals of botany
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
Alice E Adriaenssens, Berit Svendsen, Brian YH Lam, Giles SH Yeo, Jens J Holst, Frank Reimann, Fiona M Gribble
Jun 29, 2016
Alpha cells Beta cells Delta cells Ghrelin Glucagon Insulin RNA sequencing Somatostatin Animals Calcium Ghrelin Glucagon Glucagon-Secreting Cells Insulin Insulin-Secreting Cells Islets of Langerhans Male Mice Mice Inbred C57BL Mice Transgenic Reverse Transcriptase Polymerase Chain Reaction Somatostatin-Secreting Cells Transcriptome
The calcium transporter ANNEXIN1 mediates cold-induced calcium signaling and freezing tolerance in plants.
Qiangbo Liu, Yanglin Ding, Yiting Shi, Liang Ma, Yi Wang, Chunpeng Song, Katie A Wilkins, Julia M Davies, Heather Knight, Marc R Knight, Zhizhong Gong, Yan Guo, Shuhua Yang
Jan 05, 2021
The transient elevation of cytosolic free calcium concentration ([Ca2+ ]cyt ) induced by cold stress is a well-established phenomenon; however, the underlying mechanism remains elusive. Here, we report that the Ca2+ -permeable...
Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer.
Mingmin Ding, Hongbo Wang, Chunrong Qu, Fuchun Xu, Yingmin Zhu, Guangyao Lv, Yungang Lu, Qingjun Zhou, Hui Zhou, Xiaodong Zeng, Jingwen Zhang, Chunhong Yan, Jiacheng Lin, Huai-Rong Luo, Zixing Deng, Yuling Xiao, Jinbin Tian, Michael X Zhu, Xuechuan Hong
Jul 28, 2020
Transient receptor potential canonical 6 (TRPC6) proteins form receptor-operated Ca2+-permeable channels, which have been thought to bring benefit to the treatment of diseases, including cancer. However, selective antagonists...
anticancer Ca(2+) signaling Drug Discovery Nonselective cation channels TRPC channels Animals Antineoplastic Agents Apoptosis Calcium Cell Movement Cell Proliferation Gene Expression Regulation Neoplastic Humans Mice Mice Inbred BALB C Mice Nude Pyrazoles Pyrimidines Stomach Neoplasms TRPC6 Cation Channel Tumor Cells Cultured Xenograft Model Antitumor Assays
Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones.
N-Methyl-d-aspartate receptors (NMDARs) are Ca(2+)-permeable glutamate receptors that play a critical role in synaptic plasticity and promoting cell survival. However, overactive NMDARs can trigger cell death signalling pathways...
The ultrasonographic appearance of renal medullary striations and their association with renal disease and renal histopathology in domestic cats.
Medullary striations (MS) have been anecdotally observed on ultrasound of feline kidneys; however, their significance is unknown. Aims of this retrospective, case control, pilot study were to describe the appearance, prevalence...
Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.
NMDA receptor Hippocampus spike timing-dependent plasticity t-LTD t-LTP Action Potentials Animals Astrocytes CA1 Region Hippocampal CA3 Region Hippocampal Calcineurin Calcium cations Divalent Endocannabinoids long-term potentiation Long-Term Synaptic Depression Mice Inbred C57BL Neurotransmitter Agents Patch-Clamp Techniques Presynaptic Terminals Receptor Cannabinoid CB1 Receptors N-Methyl-D-Aspartate Serine Time Factors Tissue Culture Techniques
The effect of the type of HA on the degradation of PLGA/HA composites.
Buffering effects Hydroxyapatite Particle-mediated water sorption Poly(d l lactide-co-glycolide (50:50)) Calcium Durapatite Elastic Modulus Hydrogen-Ion Concentration Lactic Acid Molecular Weight Particle Size Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Powders Solutions Temperature water X-Ray Diffraction
Rapid sensing of l-leucine by human and murine hypothalamic neurons
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L Evans, Florian T Merkle, Frank Reimann, Fiona M Gribble, Clemence Blouet
Apr 05, 2018
OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Janin Lautenschläger, Amberley D Stephens, Giuliana Fusco, Florian Ströhl, Nathan Curry, Maria Zacharopoulou, Claire H Michel, Romain Laine, Nadezhda Nespovitaya, Marcus Fantham, Dorothea Pinotsi, Wagner Zago, Paul Fraser, Anurag Tandon, Peter St George-Hyslop, Eric Rees, Jonathan J Phillips, Alfonso De Simone, Clemens F Kaminski, Gabriele S Kaminski Schierle
Jul 31, 2018
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein...
Superficial and multiple calcifications and ulceration associate with intraplaque hemorrhage in the carotid atherosclerotic plaque.
Jia Yang, Xiangjun Pan, Bai Zhang, Yanhong Yan, Yabo Huang, Adam K Woolf, Jonathan H Gillard, Zhongzhao Teng, Pinjing Hui
Sep 05, 2018
Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells.
Catalin Chimerel, Edward Emery, David K Summers, Ulrich Keyser, Fiona M Gribble, Frank Reimann
Oct 01, 2014
Calcium Hydride Reduction of Polycyclic Aromatic Hydrocarbons
A molecular calcium hydride effects the two electron reduction of polyaromatic hydrocarbons, including naphthalene (E0=−3.1 V).
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells.
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, Ahmed Alrifaiy, Ingrid Wernstedt Asterholm, Anna Benrick, Margarita V Chibalina, Lena Eliasson, Claudia Guida, Thomas G Hill, Alexander Hamilton, Reshma Ramracheya, Frank Reimann, Nils JG Rorsman, Ioannis Spilliotis, Andrei I Tarasov, Jonathan N Walker, Patrik Rorsman, Linford JB Briant
Jan 23, 2020
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells1. Somatostatin is a powerful paracrine inhibitor of...
Fluctuation Analysis in Nonstationary Conditions
Fluctuation analysis is a method that allows measurement of the single-channel current of ion channels even when it is too small to be resolved directly with the patch-clamp technique. This is the case for voltage-gated calcium...
Serum magnesium and calcium levels in relation to ischemic stroke
Susanna C Larsson, Matthew Traylor, Stephen Burgess, Giorgio B Boncoraglio, Christina Jern, Karl Michaëlsson, Hugh S Markus, MEGASTROKE Project of the International Stroke Genetics Consortium
Mar 20, 2019
OBJECTIVE: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach. METHODS: Analyses were conducted using...
Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L Seifert, Marshall W Hogarth, Davi A Mazala, Kai Ting Huang, Rita Horvath, Jyoti K Jaiswal, György Hajnóczky
Apr 21, 2020
Muscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix...
Atrophy autosomal recessive Calcium Injury membrane Mitochondria mitochondrial disease muscle disease Adolescent Adult Animals Calcium Calcium Signaling Calcium-Binding Proteins Cation Transport Proteins Cell Membrane Cytosol Female FIBROBLASTS Homeostasis Humans Male Mice Knockout Mitochondria Mitochondrial Membrane Transport Proteins Models Biological Muscle Contraction Muscle Weakness Muscle Skeletal Muscular Atrophy Sarcolemma Tetanus Wasting Syndrome
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