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IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
Peace Atakpa, Nagendra Babu Thillaiappan, Stefania Mataragka, David L Prole, Colin W Taylor
Dec 21, 2018
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistribute Ca2+ from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H+-ATPase (V-ATPase)...
Ca(2+) IP(3) receptor concanamycin A Endoplasmic Reticulum genetically encoded Ca(2+) sensor lysosome membrane contact site proximity ligation assay store-operated Ca(2+) entry Calcium Calcium Signaling Cytosol Endoplasmic Reticulum HEK293 Cells HeLa Cells Humans Hydrogen-Ion Concentration Inositol 1 4 5-Trisphosphate Receptors Lysosomes
Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.
The calcium transporter ANNEXIN1 mediates cold-induced calcium signaling and freezing tolerance in plants.
Qiangbo Liu, Yanglin Ding, Yiting Shi, Liang Ma, Yi Wang, Chunpeng Song, Katie A Wilkins, Julia M Davies, Heather Knight, Marc R Knight, Zhizhong Gong, Yan Guo, Shuhua Yang
Jan 05, 2021
The transient elevation of cytosolic free calcium concentration ([Ca2+ ]cyt ) induced by cold stress is a well-established phenomenon; however, the underlying mechanism remains elusive. Here, we report that the Ca2+ -permeable...
Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.
Noemí Esteras, Olga Kopach, Marta Maiolino, Vincenzo Lariccia, Salvatore Amoroso, Seema Qamar, Selina Wray, Dmitri A Rusakov, Morana Jaganjac, Andrey Y Abramov
May 31, 2021
INTRODUCTION: The second most common form of early-onset dementia-frontotemporal dementia (FTD)-is often characterized by the aggregation of the microtubule-associated protein tau. Here we studied the mechanism of tau-induced...
4R tau AMPA receptors MAPT 10+16 NMDA receptors Calcium Signaling frontotemporal dementia Glutamate Induced Pluripotent Stem Cells mitochondrial antioxidants mitochondrial reactive oxygen species Tau frontotemporal dementia Humans Induced Pluripotent Stem Cells Mitochondria Neurons Reactive Oxygen Species Receptors N-Methyl-D-Aspartate tau Proteins
Impacts of Spike Shape Variations on Synaptic Communication.
Understanding the communication theoretical capabilities of information transmission among neurons, known as neuro-spike communication, is a significant step in developing bio-inspired solutions for nanonetworking. In this...
Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L Seifert, Marshall W Hogarth, Davi A Mazala, Kai Ting Huang, Rita Horvath, Jyoti K Jaiswal, György Hajnóczky
Apr 21, 2020
Muscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix...
Atrophy autosomal recessive Calcium Injury membrane Mitochondria mitochondrial disease muscle disease Adolescent Adult Animals Calcium Calcium Signaling Calcium-Binding Proteins Cation Transport Proteins Cell Membrane Cytosol Female FIBROBLASTS Homeostasis Humans Male Mice Knockout Mitochondria Mitochondrial Membrane Transport Proteins Models Biological Muscle Contraction Muscle Weakness Muscle Skeletal Muscular Atrophy Sarcolemma Tetanus Wasting Syndrome
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
Vittorio Vellani, Anna M Kinsey, Massimiliano Prandini, Sabine C Hechtfischer, Peter Reeh, Pier C Magherini, Chiara Giacomoni, Peter A McNaughton
Jun 16, 2011
Animals Animals Newborn Calcitonin Gene-Related Peptide Calcium Signaling Ganglia Spinal Hot Temperature Immunohistochemistry In Situ Hybridization In Vitro Techniques Ion Channel Gating Nerve Growth Factors Nociceptors Protein Kinase C-epsilon Protein Transport Rats Rats Sprague-Dawley Receptor PAR-1 Receptors Thrombin TRPV Cation Channels Thrombin Up-Regulation
Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.
Ca2+ signalling Cyclic AMP Inositol trisphosphate receptor Parathyroid hormone Adenylyl Cyclases Calcium Calcium Signaling Carbachol Colforsin Cyclic AMP Cyclic AMP-Dependent Protein Kinases Cytosol HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Parathyroid Hormone Receptor Parathyroid Hormone Type 1
Calcium Na(+)/K(+)-ATPase Platelet Protein Kinase C Sarco/endoplasmic reticulum Ca(2+)-ATPase Adenosine Diphosphate Blood Platelets Calcium Calcium Channels Calcium Signaling Cell Membrane Cytosol Humans Indoles Isoenzymes Platelet Activation Platelet Aggregation Inhibitors Protein Isoforms Protein Kinase C Thrombin
All three IP3 receptor subtypes generate Ca2+ puffs, the universal building blocks of IP3-evoked Ca2+ signals.
All three subtypes of inositol 1,4,5-trisphosphate receptor (IP3R) are intracellular Ca2+ channels that are co-regulated by IP3 and Ca2+ This allows IP3Rs to evoke regenerative Ca2+ signals, the smallest of which are Ca2+ puffs...
Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron.
Wenjuan Zou, Jiajun Fu, Haining Zhang, Kang Du, Wenming Huang, Junwei Yu, Shitian Li, Yuedan Fan, Howard A Baylis, Shangbang Gao, Rui Xiao, Wei Ji, Lijun Kang, Tao Xu
Nov 30, 2018
How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors...
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells.
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease. However, the...
Airway smooth muscle Ca(2+) signaling Cyclic AMP Histamine Protein kinase A Spatial organization Adult Bronchi Calcium Signaling Cell Compartmentation Child Child Preschool Cyclic AMP Cyclic AMP-Dependent Protein Kinases Dinoprostone Histamine Humans Inositol 1 4 5-Trisphosphate Receptors Isoproterenol Myocytes Smooth Muscle Pertussis Toxin Receptors Prostaglandin E EP2 Subtype Receptors Prostaglandin E EP4 Subtype Type C Phospholipases
Nuclear calcium signatures are associated with root development.
In plants, nuclear Ca2+ releases are essential to the establishment of nitrogen-fixing and phosphate-delivering arbuscular mycorrhizal endosymbioses. In the legume Medicago truncatula, these nuclear Ca2+ signals are generated by...
Sarcoplasmic reticular Ca2+-ATPase inhibition paradoxically upregulates murine skeletal muscle Nav1.4 function.
Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic...
Animals caffeine Calcium Channel Agonists Calcium Signaling Cells Cultured Indoles Mice Muscle Fibers Skeletal Muscle Skeletal NAV1.4 Voltage-Gated Sodium Channel Patch-Clamp Techniques Primary Cell Culture Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Sarcoplasmic Reticulum Calcium-Transporting ATPases sodium Up-Regulation
P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors.
Sin-Lih Tan, Muruj Barri, Peace Atakpa-Adaji, Colin W Taylor, Ewan St John Smith, Ruth D Murrell-Lagnado
Oct 01, 2021
The P2X4 purinergic receptor is targeted to endolysosomes, where it mediates an inward current dependent on luminal ATP and pH. Activation of P2X4 receptors was previously shown to trigger lysosome fusion, but the regulation of...
Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling
Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane permeabilization (MOMP): a central step in the mitochondrial pathway of...
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation.
Ian Winfield, Kerry Barkan, Sarah Routledge, Nathan J Robertson, Matthew Harris, Ali Jazayeri, John Simms, Christopher A Reynolds, David R Poyner, Graham Ladds
Jan 28, 2022
The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8th helix (H8), it is involved in early conformational changes following...
CLR GPCRs RAMPs Mutagenesis signaling bias Amino Acid Motifs Calcitonin Receptor-Like Protein Calcium Signaling Cyclic AMP HEK293 Cells Humans MAP Kinase Signaling System Molecular Dynamics Simulation Protein Domains Protein Structure Tertiary Receptor Activity-Modifying Protein 1 Receptors Calcitonin Gene-Related Peptide Receptors Corticotropin-Releasing Hormone Receptors G-Protein-Coupled Receptors Glucagon
Absence of platelet phenotype in mice lacking the motor protein myosin Va.
BACKGROUND: The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both...
Iron availability modulates the Arabidopsis thaliana root calcium signature evoked by exogenous ATP.
Plants use changes in cytosolic free Ca2+ ("signatures") to encode information from the specific signals generated in development, immunity and stress perception. Phosphate availability has a significant impact on the...
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
Aleks Ponjavic, James McColl, Alexander R Carr, Ana Mafalda Santos, Klara Kulenkampff, Anna Lippert, Simon J Davis, David Klenerman, Steven F Lee
Apr 11, 2019
Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this...
A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.
Zhu-Hong Li, Thayer P King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A Vella, Isabelle Coppens, Sandip Patel, Silvia NJ Moreno
Nov 25, 2021
Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca2+-dependent events. Little is known about TPCs in unicellular organisms despite...
Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions.
Nagendra Babu Thillaiappan, Alap P Chavda, Stephen C Tovey, David L Prole, Colin W Taylor
Jun 12, 2018
IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization of IP3Rs determines both the propagation of Ca2+ signals between IP3Rs and the selective regulation of cellular responses. Here...
True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors.
Isuru Jayasinghe, Alexander H Clowsley, Ruisheng Lin, Tobias Lutz, Carl Harrison, Ellen Green, David Baddeley, Lorenzo Di Michele, Christian Soeller
Jun 28, 2018
Signaling nanodomains rely on spatial organization of proteins to allow controlled intracellular signaling. Examples include calcium release sites of cardiomyocytes where ryanodine receptors (RyRs) are clustered with their...
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