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![Cover Image for Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.](https://coverimages.igi-global.com/images/search-article.png)
Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.
Jack J Miller, Angus Z Lau, Per Mose Nielsen, Giles McMullen-Klein, Andrew J Lewis, Nichlas Riise Jespersen, Vicky Ball, Ferdia A Gallagher, Carolyn A Carr, Christoffer Laustsen, Hans Erik Bøtker, Damian J Tyler, Marie A Schroeder
Feb 11, 2019
OBJECTIVES: The aim of this study was to determine if hyperpolarized [1,4-13C2]malate imaging could measure cardiomyocyte necrosis after myocardial infarction (MI). BACKGROUND: MI is defined by an acute burst of cellular...
cardiac MRI Energy Metabolism hyperpolarized MR Magnetic Resonance Spectroscopy Necrosis Animals Carbon Isotopes Carbon-13 Magnetic Resonance Spectroscopy Contrast Media Energy Metabolism Fumarates Isolated Heart Preparation Magnetic Resonance Imaging Cine Malates Male Molecular Imaging Myocardial Infarction Myocytes Cardiac Necrosis Predictive Value of Tests Rats Wistar
Eva M Serrao, Mikko I Kettunen, Tiago B Rodrigues, Piotr Dzien, Alan J Wright, Aarthi Gopinathan, Ferdia A Gallagher, David Y Lewis, Kristopher K Frese, Jaime Almeida, William J Howat, David A Tuveson, Kevin M Brindle
Aug 07, 2015
Hyperpolarized 13C MRI
James T Grist, Jack J Miller, Fulvio Zaccagna, Mary A McLean, Frank Riemer, Tomasz Matys, Damian J Tyler, Christoffer Laustsen, Alasdair J Coles, Ferdia A Gallagher
Mar 17, 2020
Cerebral metabolism is tightly regulated and fundamental for healthy neurological function. There is increasing evidence that alterations in this metabolism may be a precursor and early biomarker of later stage disease...
Probing hepatic metabolism of [2- 13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR
Irene Marco-Rius, Alan J. Wright, De-En Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment
Sep 10, 2021
RESEARCH ARTICLE Basic Science - Preclinical spectroscopy Carbon-13 Magnetic Resonance Spectroscopy Gluconeogenesis Glycolysis Liver metabolism Dynamic Nuclear Polarisation Hyperpolarisation
Published by: Springer International Publishing
Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.
Eva M Serrao, Tiago B Rodrigues, Ferdia A Gallagher, Mikko I Kettunen, Brett WC Kennedy, Sarah L Vowler, Keith A Burling, Kevin M Brindle
Jun 16, 2016
Cancer Fasting hyperpolarization Lymphoma Pyruvate REPEATABILITY Algorithms Animals Biomarkers Tumor Carbon-13 Magnetic Resonance Spectroscopy Fasting Female Mice Mice Inbred C57BL Neoplasms Experimental Pyruvic Acid Reproducibility of Results Sensitivity and Specificity Signal Processing Computer-Assisted
Probing hepatic metabolism of [2- 13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR
Irene Marco-Rius, Alan J. Wright, De-En Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment
Feb 26, 2021
RESEARCH ARTICLE Basic Science - Preclinical spectroscopy Carbon-13 Magnetic Resonance Spectroscopy Gluconeogenesis Glycolysis Liver metabolism Dynamic Nuclear Polarisation Hyperpolarisation
Published by: Springer International Publishing
1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase.
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.
Irene Marco-Rius, Alan J Wright, De-En Hu, Dragana Savic, Jack J Miller, Kerstin N Timm, Damian Tyler, Kevin M Brindle, Arnaud Comment
Sep 02, 2020
OBJECTIVES: To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substrate...
(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.
Piotr Dzien, Sui-Seng Tee, Mikko I Kettunen, Scott K Lyons, Timothy J Larkin, Kerstin N Timm, De-En Hu, Alan Wright, Tiago B Rodrigues, Eva M Serrao, Irene Marco-Rius, Elizabeth Mannion, Paula D'Santos, Brett WC Kennedy, Kevin M Brindle
Aug 06, 2015
Zymomonas mobilis pyruvate decarboxylase hyperpolarized [1-13C] pyruvate reporter genes Animals Carbon-13 Magnetic Resonance Spectroscopy Enzyme Activation Female Genes Reporter HEK293 Cells Humans Magnetic Resonance Imaging Mice Mice SCID Molecular Imaging pyruvate decarboxylase Pyruvic Acid Recombinant Proteins Reproducibility of Results Sensitivity and Specificity Tissue Distribution Zymomonas
Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.