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Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells.
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease. However, the...
Airway smooth muscle Ca(2+) signaling Cyclic AMP Histamine Protein kinase A Spatial organization Adult Bronchi Calcium Signaling Cell Compartmentation Child Child Preschool Cyclic AMP Cyclic AMP-Dependent Protein Kinases Dinoprostone Histamine Humans Inositol 1 4 5-Trisphosphate Receptors Isoproterenol Myocytes Smooth Muscle Pertussis Toxin Receptors Prostaglandin E EP2 Subtype Receptors Prostaglandin E EP4 Subtype Type C Phospholipases
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization.
Antonio D Barbosa, Koini Lim, Muriel Mari, James R Edgar, Lihi Gal, Peter Sterk, Benjamin J Jenkins, Albert Koulman, David B Savage, Maya Schuldiner, Fulvio Reggiori, Philip A Wigge, Symeon Siniossoglou
Jul 08, 2019
Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl...
lipid droplet nuclear membrane NUCLEUS phospholipid triglyceride Biocatalysis Cell Compartmentation Cell Cycle Cell Nucleolus Cell Nucleus Shape Homeostasis Imaging Three-Dimensional Lipid Droplets Nuclear Envelope Phospholipids Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Triglycerides
Metabolic Reprogramming and Oncogenesis
The process of tumorigenesis can be described by a series of molecular features, among which alteration of cellular metabolism has recently emerged. This metabolic rewiring fulfills the energy and biosynthetic demands of fast...
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment
K Kirschner, T Chandra, V Kiselev, D Flores-Santa Cruz, IC Macaulay, HJ Park, J Li, DG Kent, R Kumar, DC Pask, TL Hamilton, M Hemberg, W Reik, AR Green
Jul 26, 2017
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct...
Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.
A fundamental question in developmental and stem cell biology concerns the origin and nature of signals that initiate asymmetry leading to pattern formation and self-organization. Instead of having prominent pre-patterning...
Proteome Mapping of a Cyanobacterium Reveals Distinct Compartment Organization and Cell-Dispersed Metabolism.
Laura L Baers, Lisa M Breckels, Lauren A Mills, Laurent Gatto, Michael J Deery, Tim J Stevens, Christopher J Howe, Kathryn S Lilley, David J Lea-Smith
Oct 29, 2019
Cyanobacteria are complex prokaryotes, incorporating a Gram-negative cell wall and internal thylakoid membranes (TMs). However, localization of proteins within cyanobacterial cells is poorly understood. Using subcellular...