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Results: 29
Thyroid Hormone Deficiency Suppresses Fetal Pituitary-Adrenal Function Near Term
Emily J Camm, Isabella Inzani, Miles J De Blasio, Katie L Davies, India R Lloyd, FB Peter Wooding, Dominique Blache, Abigail L Fowden, Alison J Forhead
Oct 22, 2020
ACTH adrenal gland corticotrophs Cortisol Fetus Pituitary Gland Thyroid Hormones Adrenal Cortex Hormones Adrenal Glands Adrenal Medulla Adrenocorticotropic Hormone Animals Cell Count Cell Proliferation congenital hypothyroidism Corticotrophs Fetal Development Fetal Diseases Fetal Organ Maturity Hydrocortisone Hypothalamo-Hypophyseal System Insulin-Like Growth Factor I Pituitary-Adrenal System RNA Messenger Receptor IGF Type 1 Sheep Thyroidectomy Thyroxine Triiodothyronine Zona Fasciculata
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.
Helen Bolton, Sarah JL Graham, Niels Van der Aa, Parveen Kumar, Koen Theunis, Elia Fernandez Gallardo, Thierry Voet, Magdalena Zernicka-Goetz
Mar 30, 2016
Aneuploidy Animals Blastocyst Cell Count Cell Lineage Chromosome Segregation Chromosomes Mammalian Embryo Implantation Female Fertilization in Vitro Humans In Situ Hybridization Fluorescence Male Mice Mice Inbred C57BL Mice Inbred CBA Mitosis Models Genetic Morpholines Mosaicism Protein Kinase Inhibitors Purines Zygote
The effects of scaffold architecture and fibrin gel addition on tendon cell phenotype.
Three-tier regulation of cell number plasticity by neurotrophins and Tolls in $\textit{Drosophila}$
I Foldi, N Anthoney, N Harrison, M Gangloff, B Verstak, MP Nallasivan, S AlAhmed, B Zhu, M Phizacklea, M Losada-Perez, M Moreira, NJ Gay, A Hidalgo
May 05, 2017
Accuracy and Safety of the Cytosponge for Assessing Histologic Activity in Eosinophilic Esophagitis
David A Katzka, Thomas C Smyrk, Jeffrey A Alexander, Debra M Geno, RoseMary A Beitia, Audrey O Chang, Nicholas J Shaheen, Rebecca C Fitzgerald, Evan S Dellon
Jul 13, 2018
Adult Biopsy Cell Count Cross-Sectional Studies Dimensional Measurement Accuracy Eosinophilic Esophagitis Eosinophils Esophagoscopy esophagus Female Humans Male Middle Aged Monitoring Physiologic Mucous Membrane Patient acuity Patient Preference Prospective Studies Specimen Handling Statistics as Topic Surgical Sponges United States
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
PK Yip, A Carrillo-Jimenez, P King, A Vilalta, K Nomura, CC Chau, AMS Egerton, Z-H Liu, AJ Shetty, JL Tremoleda, M Davies, T Deierborg, JV Priestley, GC Brown, AT Michael-Titus, JL Venero, MA Burguillos
Apr 19, 2017
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis.
Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A Frake, Alejandro Carnicer Lombarte, Carla F Bento, Kristian Franze, David C Rubinsztein
Sep 08, 2018
Actin Cytoskeleton Actins Acyltransferases Adaptor Proteins Signal Transducing Animals Apoptosis Autophagosomes Autophagy CapZ Actin Capping Protein Cell Count Cell Line Tumor Cell Proliferation Cell Survival Contact Inhibition Epithelial Cells Extracellular Matrix FIBROBLASTS Gene Knockdown Techniques Glucose HeLa Cells Humans Hypoxia Mice Myosin Type II Phosphoproteins Signal Transduction Transcription Factors YAP-Signaling Proteins
Population dynamics of normal human blood inferred from somatic mutations.
Henry Lee-Six, Nina Friesgaard Øbro, Mairi S Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J Osborne, Brian JP Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O'Neill, Michael R Stratton, Elisa Laurenti, Anthony R Green, David G Kent, Peter J Campbell
Sep 21, 2018
LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.
Lalarukh Haris Shaikh, Junhua Zhou, Ada ED Teo, Sumedha Garg, Sudeshna Guha Neogi, Nichola Figg, Giles S Yeo, Haixiang Yu, Janet J Maguire, Wanfeng Zhao, Martin R Bennett, Elena AB Azizan, Anthony P Davenport, Grahame McKenzie, Morris J Brown
Jun 05, 2015
Rapid in-house method of CSF analysis utilising sedimentation direct from the spinal needle.
OBJECTIVES: To establish the utility of a novel in-house method of CSF analysis using sedimentation cytology direct from the spinal needle for the detection of laboratory-defined pleocytosis. MATERIALS AND METHODS: In dogs and...
Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain.
Amelia J Thompson, Eva K Pillai, Ivan B Dimov, Sarah K Foster, Christine E Holt, Kristian Franze
Jan 29, 2019
Tissue mechanics is important for development; however, the spatio-temporal dynamics of in vivo tissue stiffness is still poorly understood. We here developed tiv-AFM, combining time-lapse in vivo atomic force microscopy with...
Evaluation of the Idexx ProCyte Dx® for analysis of canine cerebrospinal fluid.
OBJECTIVES: To assess the utility of the Idexx ProCyte Dx® haematology analyser for assessing total nucleated cell count and differential cell counts in canine cerebrospinal fluid. MATERIALS AND METHODS: Seventy-three...
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
Emanuel Rognoni, Celine Gomez, Angela Oliveira Pisco, Emma L Rawlins, Ben D Simons, Fiona M Watt, Ryan R Driskell
Aug 17, 2018
New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at...
Fibroblast lineages Wounding β-catenin aging Animals Animals Newborn Apoptosis Biomarkers Cell Count Cell Differentiation Cell Proliferation Clone Cells Dermis FIBROBLASTS Gene Expression Profiling Gene Expression Regulation Developmental Green Fluorescent Proteins Hair Follicle Homeostasis Integrases Mice Inbred C57BL Organogenesis Receptor Platelet-Derived Growth Factor alpha Regeneration Signal Transduction Tail Time Factors Wnt Signaling Pathway Wound Healing beta Catenin
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Florian T Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier, Robert E Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A McCarroll, Kevin Eggan
May 01, 2017
Alleles Cell Count Cell Differentiation Cell Division Cell Line DNA DNA Mutational Analysis Exome Genes Dominant Genes p53 Human Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Loss of Heterozygosity Mosaicism Mutation Neoplasms Protein Domains selection Genetic Tumor Suppressor Protein p53
Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people
M Byford, C Brayne, I McKeith, M Chatfield, Pg Ince, FE Matthews, MRC CFAS Neuropathology group
Jun 16, 2011
BACKGROUND: Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in subcortical areas of...
Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells.
Mojtaba Abdi-Jalebi, M Ibrahim Dar, Aditya Sadhanala, Satyaprasad P Senanayak, Michael Grätzel, Richard H Friend
Nov 01, 2016
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool.
Nicole Prior, Christopher J Hindley, Fabian Rost, Elena Meléndez, Winnie WY Lau, Berthold Göttgens, Steffen Rulands, Benjamin D Simons, Meritxell Huch
May 17, 2019
Bipotent Hepatoblast Lgr5 Liver development Liver stem/progenitor cells Organoid Alleles Animals Base Sequence Cell Count Cell Culture Techniques Cell Differentiation Cell Lineage Cells Cultured Embryonic Development Epithelial Cells Female Gene Expression Regulation Developmental Hepatocytes Homeostasis Liver Male Mice Microscopy Confocal Receptors G-Protein-Coupled Stem Cells
The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex.
Erin Knock, João Pereira, Patrick D Lombard, Andrew Dimond, Donna Leaford, Frederick J Livesey, Brian Hendrich
Jun 08, 2015
Animals Cell Count Cell Cycle Cell Lineage Cerebral Cortex DNA-Binding Proteins Eye Proteins Gene Expression Profiling Gene Expression Regulation Developmental Homeodomain Proteins Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Mice Knockout Neural Stem Cells Neurogenesis Neurons Nucleosomes PAX6 Transcription Factor Paired Box Transcription Factors Repressor Proteins T-Box Domain Proteins Transcription Factors Transcription Genetic Transgenes
How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?
Oisín Huhn, Xiaohui Zhao, Laura Esposito, Ashley Moffett, Francesco Colucci, Andrew M Sharkey
Jul 30, 2021
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly...
Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow.
Etienne Paubelle, Florence Zylbersztejn, Thiago Trovati Maciel, Caroline Carvalho, Annalisa Mupo, Meyling Cheok, Liesbet Lieben, Pierre Sujobert, Justine Decroocq, Akihiko Yokoyama, Vahid Asnafi, Elizabeth Macintyre, Jérôme Tamburini, Valérie Bardet, Sylvie Castaigne, Claude Preudhomme, Hervé Dombret, Geert Carmeliet, Didier Bouscary, Yelena Z Ginzburg, Hughes de Thé, Marc Benhamou, Renato C Monteiro, George S Vassiliou, Olivier Hermine, Ivan C Moura
Feb 07, 2020
Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly on antimitotic chemotherapy. Here, we present an...
acute myeloid leukemia Leukemic stem cell vitamin D receptor Animals Apoptosis Azacitidine Bone Marrow Cell Count Cell Cycle Cell Differentiation Cell Line Tumor DNA (Cytosine-5-)-Methyltransferases DNA Methylation Disease Progression Female Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Humans Leukemia Myeloid Acute Mice Inbred C57BL Monocytes Myeloid Cells Neoplastic Stem Cells Oncogenes Promoter Regions Genetic Receptors Calcitriol Signal Transduction Survival Analysis Tumor Stem Cell Assay
Snow algae communities in Antarctica
Matthew P Davey, Louisa Norman, Peter Sterk, Maria Huete-Ortega, Freddy Bunbury, Bradford Kin Wai Loh, Sian Stockton, Lloyd S Peck, Peter Convey, Kevin K Newsham, Alison G Smith
Feb 05, 2019
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Michael Segel, Björn Neumann, Myfanwy FE Hill, Isabell P Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C Agley, Amelia J Thompson, Ginez A Gonzalez, Amar Sharma, Steffan Holmqvist, David H Rowitch, Kristian Franze, Robin Jm Franklin, Kevin J Chalut
Aug 21, 2019
Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Cell migration relies on coordinated activity of chemotactic and guidance receptors. Here, we report a specific role for the RNA-binding protein ZFP36L1 in limiting the abundance of molecules involved in the homing of...
Animals Antibody-Producing Cells Antigens B-Lymphocytes Base Sequence Bone Marrow Butyrate Response Factor 1 Cell Count Cell Death Cell Membrane Cell Movement G-Protein-Coupled Receptor Kinase 2 Gene Expression Regulation Germinal Center Immunization Integrins Lysophospholipids Mice Inbred C57BL Receptors CXCR4 Receptors G-Protein-Coupled Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen
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