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Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery.
Gonzalo Millan-Zambrano, Helena Santos-Rosa, Fabio Puddu, Samuel C Robson, Stephen P Jackson, Tony Kouzarides
Dec 03, 2018
Cla4 DNA damage checkpoint H4T80ph PAK Rad53 Rad9 Rtt107 Histone modifications Cell Cycle Checkpoints Cell Cycle Proteins Checkpoint Kinase 2 DNA Damage DNA Repair Histones Intracellular Signaling Peptides and Proteins Nuclear Proteins Phosphorylation Protein Binding Protein Serine-Threonine Kinases Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction
Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.
Helena Carén, Stefan H Stricker, Harry Bulstrode, Sladjana Gagrica, Ewan Johnstone, Thomas E Bartlett, Andrew Feber, Gareth Wilson, Andrew E Teschendorff, Paul Bertone, Stephan Beck, Steven M Pollard
Apr 12, 2019
Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stemcell-like cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stemcells (GSCs) and, therefore, might have therapeutic value....
HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions
Cell Cycle Checkpoints Cells Cultured Enzyme Activation Fluorescent Antibody Technique Gene Amplification Genome Viral Human papillomavirus 16 Human papillomavirus 18 Humans Immunoblotting Immunohistochemistry In Situ Hybridization Fluorescence Keratinocytes Life Cycle Stages Mutagenesis Site-Directed Oncogene Proteins Viral Real-Time Polymerase Chain Reaction Virus Replication
The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion.
Ting Deng, Przemyslaw Stempor, Alex Appert, Michael Daube, Julie Ahringer, Alex Hajnal, Evelyn Lattmann
May 15, 2020
Cell invasion allows cells to migrate across compartment boundaries formed by basement membranes. Aberrant cell invasion is a first step during the formation of metastases by malignant cancer cells. Anchor cell (AC) invasion in...
Animals Basement Membrane Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Checkpoints Cell Differentiation Cell Proliferation G1 Phase Cell Cycle Checkpoints Gene Expression MDS1 and EVI1 Complex Locus Protein Proto-Oncogene Mas Proto-Oncogene Proteins c-fos Proto-Oncogenes Receptors Notch Signal Transduction Transcription Factors
CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.
Anna Hupalowska, Agnieszka Jedrusik, Meng Zhu, Mark T Bedford, David M Glover, Magdalena Zernicka-Goetz
Dec 21, 2018
Nuclear architecture has never been carefully examined during early mammalian development at the stages leading to establishment of the embryonic and extra-embryonic lineages. Heterogeneous activity of the methyltransferase...
CARM1 Cell fate development Embryo Heterogeneity nuclear bodies p54/nrb paraspeckles phase-separation pre-implantation Animals Blastocyst Cell Cycle Checkpoints Cell Differentiation Cell Lineage Embryonic Development Mice Nuclear Matrix-Associated Proteins Protein-Arginine N-Methyltransferases RNA Long Noncoding RNA-Binding Proteins
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, MS Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D Toop, Monika Dudek, Samuel C Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A Garyfallos, Hannes Ponstingl, Joao ML Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J Bannister, Roland Rad, Rab K Prinjha, John C Marioni, Brian Huntly, Jennifer Batson, Jonathan C Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O Bates, Kosuke Yusa, Tony Kouzarides, George S Vassiliou
Jan 08, 2019
We recently identified the splicing kinase gene SRPK1 as a genetic vulnerability of acute myeloid leukemia (AML). Here, we show that genetic or pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukemic cell...
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line.
Claire M Mulvey, Lisa M Breckels, Oliver M Crook, David J Sanders, Andre LR Ribeiro, Aikaterini Geladaki, Andy Christoforou, Nina Kočevar Britovšek, Tracey Hurrell, Michael J Deery, Laurent Gatto, Andrew M Smith, Kathryn S Lilley
Sep 13, 2021
Algorithms Anti-Infective Agents Anti-Inflammatory Agents Antigen Presentation Autophagosomes Bayes Theorem Cell Cycle Checkpoints Cell Membrane Cell Nucleus Cell Shape Humans Immunity Inflammation Leukemia Lipopolysaccharides Lymphocyte Activation Lysosomes Neoplasm Proteins Protein Transport Proteome Proteomics Signal Transduction T-Lymphocytes THP-1 Cells Time Factors Transport Vesicles Up-Regulation rho GTP-Binding Proteins
Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation.
Felicity E Stubbs, Benjamin P Flynn, Caroline A Rivers, Matthew T Birnie, Andrew Herman, Erin E Swinstead, Songjoon Baek, Hai Fang, Jillian Temple, Jason S Carroll, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell
Dec 09, 2022
Developmental potential of aneuploid human embryos cultured beyond implantation.
Marta N Shahbazi, Tianren Wang, Xin Tao, Bailey AT Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D Smith, Antonio Pellicer, Richard T Scott, Emre Seli, Magdalena Zernicka-Goetz
Jul 20, 2020
Aneuploidy, the presence of an abnormal number of chromosomes, is a major cause of early pregnancy loss in humans. Yet, the developmental consequences of specific aneuploidies remain unexplored. Here, we determine the extent of...
Aneuploidy Antigens CD Cadherins Cell Adhesion Cell Cycle Checkpoints Cell Lineage Chromosome Segregation Chromosomes Human Pair 16 Chromosomes Human Pair 21 Embryo Implantation Embryo Mammalian Embryonic Development Female Genes erbB-1 Genetic Testing Humans Monosomy Mosaicism Pregnancy Stem Cells Trisomy
A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.
Cara B Eldridge, Finian J Allen, Alastair Crisp, Rodrigo A Grandy, Ludovic Vallier, Julian E Sale
Sep 23, 2020
The ability of human induced pluripotent stem cells (hiPSCs) to differentiate in vitro to each of the three germ layer lineages has made them an important model of early human development and a tool for tissue engineering....
Cell Cycle Regulation in Macrophages and Susceptibility to HIV-1.
Macrophages are the first line of defence against invading pathogens. They play a crucial role in immunity but also in regeneration and homeostasis. Their remarkable plasticity in their phenotypes and function provides them with...
G0/G1 phase HIV SAMHD1 cell arrest Cell Cycle macrophage Animals Cell Cycle Cell Cycle Checkpoints Cells Cultured DNA Damage G1 Phase Gram-Negative Bacteria HIV-1 Histone Deacetylase Inhibitors Humans MACROPHAGES Phosphorylation Resting Phase Cell Cycle SAM Domain and HD Domain-Containing Protein 1 vif Gene Products Human Immunodeficiency Virus vpr Gene Products Human Immunodeficiency Virus
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.
Annarita Favia, Luisa Salvatori, Simona Nanni, Lisa K Iwamoto-Stohl, Sergio Valente, Antonello Mai, Fiorella Scagnoli, Rosaria Anna Fontanella, Pierangela Totta, Sergio Nasi, Barbara Illi
Nov 03, 2020
Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and...
Antibodies Cell Cycle Checkpoints Cell Differentiation Cell Line Tumor Glioblastoma HEK293 Cells Humans Methylation Neoplastic Stem Cells Promoter Regions Genetic Protein Binding Protein Stability Protein-Arginine N-Methyltransferases Proto-Oncogene Proteins c-myc RNA Interference RNA Small Interfering Repressor Proteins SOXB1 Transcription Factors
Cellular Senescence
Vassilis Gorgoulis, Peter D Adams, Andrea Alimonti, Dorothy C Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B Maier, Masashi Narita, Laura Niedernhofer, João F Passos, Paul D Robbins, Clemens A Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria
Nov 25, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related...
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Apr 14, 2021
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to...
The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.
Like all DNA viruses, human cytomegalovirus (HCMV) infection is known to result in profound effects on host cell cycle. Infection of fibroblasts with HCMV is known to induce an advance in cell cycle through the G(0)-G(1) phase...
Acetyltransferases Cell Cycle Checkpoints Cells Cultured Cytomegalovirus DNA Replication FIBROBLASTS Gene Expression HEK293 Cells Host-Pathogen Interactions Humans Immediate-Early Proteins Intracellular Signaling Peptides and Proteins Plasmids RNA Small Interfering Trans-Activators Transfection Virus Replication
NOTCH1 mediates a switch between two distinct secretomes during senescence
M Hoare, Y Ito, T-W Kang, MP Weekes, NJ Matheson, DA Patten, S Shetty, AJ Parry, S Menon, R Salama, R Antrobus, K Tomimatsu, W Howat, PJ Lehner, L Zender, M Narita
Sep 19, 2017
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Eric H Ma, Glenn Bantug, Takla Griss, Stephanie Condotta, Radia M Johnson, Bozena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L Balmer, Mark J Verway, Thomas C Raissi, Harmony Tsui, Giselle Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M Krawczyk, Adam Friedman, Mark Manfredi, Martin J Richer, Christoph Hess, Russell G Jones
Jan 12, 2018
During immune challenge, T lymphocytes engage pathways of anabolic metabolism to support clonal expansion and the development of effector functions. Here we report a critical role for the non-essential amino acid serine in...
Phgdh Shmt T cell Glycolysis immunometabolism Immunotherapy Metabolic reprogramming metabolism Serine serine biosynthesis Animals Carbon Cell Cycle Checkpoints Cell Proliferation Diet Energy Metabolism Extracellular Space Glycine Listeria monocytogenes Metabolic Networks and Pathways Metabolome Mice Inbred C57BL Purine Nucleotides Serine T-Lymphocytes
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
Simon JA Buczacki, Semiramis Popova, Emma Biggs, Chrysa Koukorava, Jon Buzzelli, Louis Vermeulen, Lee Hazelwood, Hayley Francies, Mathew J Garnett, Douglas J Winton
Sep 05, 2018
Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant...
Animals Cell Cycle Cell Cycle Checkpoints Cell Differentiation Cell Line Tumor Cell Proliferation Cell Separation Cellular Senescence Colorectal Neoplasms Humans Itraconazole Mice Neoplastic Stem Cells Organoids Phenotype Receptors G-Protein-Coupled Spheroids Cellular Staining and Labeling Wnt Signaling Pathway
Modelling of the cancer cell cycle as a tool for rational drug development
The dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways. It has been argued that selectivity of treatments could exploit loss of checkpoint function in cancer cells, a concept...
Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression.
Fbxo7 anaemia Cell Cycle DIFFERENTIATION mitophagy rs11107 ubiquitin ligase Anemia Animals Cell Cycle Checkpoints Cell Line Tumor Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation Erythrocytes Erythropoiesis F-Box Proteins Genotype Hemoglobins Mice Knockout Mitochondria Mitophagy Phenotype Protein Stability RNA Interference Signal Transduction Time Factors Transfection
Chronic Hepatitis B Virus Infection
Phaedra M Tachtatzis, Aileen Marshall, Aloysious Arvinthan, Suman Verma, Sue Penrhyn-Lowe, Marianna Mela, Cinzia Scarpini, Susan E Davies, Nicholas Coleman, Graeme JM Alexander
Aug 19, 2020
BACKGROUND: Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the...
A guide to assessing cellular senescence in vitro and in vivo.
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly dynamic and regulated cellular state plays...
Ageing assessment Biomarkers Cellular Senescence detection aging Animals Animals Genetically Modified Biomarkers Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Cell Shape Cells Cultured Cellular Senescence Cytokines DNA Damage Genetic Loci Heterochromatin Humans Lamin Type B Lysosomes Mitochondria
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.
Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia MW Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy
Jan 15, 2021
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage...
Animals Binding Sites Breast Neoplasms Cell Adhesion Cell Cycle Checkpoints Cell Line Tumor Cell Proliferation Chromatin Immunoprecipitation DNA Neoplasm DNA-Binding Proteins Drug Resistance Neoplasm Estrogens Female Gene Expression Regulation Neoplastic Genome Human Humans Mice Models Biological Phenotype Protein Binding Proto-Oncogene Proteins c-ets Sequence Analysis DNA Transcription Factors Transcription Genetic
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare, Y Ito, T-W Kang, Michael Weekes, Nicholas Matheson, DA Patten, S Shetty, Aled Parry, S Menon, R Salama, R Antrobus, K Tomimatsu, W Howat, Paul Lehner, L Zender, Masashi Narita
Jul 27, 2016
The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.
G Giotopoulos, W-I Chan, SJ Horton, D Ruau, P Gallipoli, A Fowler, C Crawley, E Papaemmanuil, PJ Campbell, B Göttgens, JM Van Deursen, PA Cole, BJP Huntly
May 18, 2015
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