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Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law
Raymond Goldstein, Thomas C Day, Stephanie Hoehn, Seyed A Zamani-Dahaj, David Yanni, Anthony Burnetti, Jennifer Pentz, Aurelia R Honerkamp-Smith, Hugo Wioland, Hannah R Sleath, William C Ratcliff, Peter J Yunker
Mar 28, 2022
The prevalence of multicellular organisms is due in part to their ability to form
complex structures. How cells pack in these structures is a fundamental biophysical issue,
underlying their functional properties. However, much...
Advances in understanding the pathogenesis of hereditary macrothrombocytopenia.
Genomics macrothrombocytopenia megakaryopoiesis platelets polygenic Adolescent Adult Aged Blood Platelets Cell Size Cohort Studies Female Genetic Heterogeneity Genome-Wide Association Study Humans Male Mean Platelet Volume Middle Aged Multifactorial Inheritance Phenotype Platelet Count Thrombocytopenia Transcription Factors Young Adult
FRET imaging of hemoglobin concentration in Plasmodium falciparum-infected red cells.
Alessandro Esposito, Teresa Tiffert, Jakob MA Mauritz, Simon Schlachter, Lawrence H Bannister, Clemens F Kaminski, Virgilio L Lew
Jan 25, 2021
BACKGROUND: During its intraerythrocytic asexual reproduction cycle Plasmodium falciparum consumes up to 80% of the host cell hemoglobin, in large excess over its metabolic needs. A model of the homeostasis of...
Investigating biomechanical noise in neuroblastoma cells using the quartz crystal microbalance.
biomechanical noise frequency stability neuroblastoma cells quartz crystal microbalance Biosensing Techniques Cell Line Tumor Cell Movement Cell Size Elastic Modulus Equipment Design Equipment Failure Analysis Humans Micro-Electrical-Mechanical Systems Neuroblastoma Neurons Reproducibility of Results Sensitivity and Specificity Signal-To-Noise Ratio Stress Mechanical
The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia.
Halima Al Balushi, Kobina Dufu, David C Rees, John N Brewin, Anke Hannemann, Donna Oksenberg, David C-Y Lu, John S Gibson
Feb 28, 2019
GBT1118 O2 affinity sickle cell anemia cell volume Hemolysis Potassium permeability sickling Anemia Sickle Cell Antisickling Agents Benzaldehydes Cell Size Erythrocyte Membrane Hemoglobin Sickle Hemolysis Humans Intermediate-Conductance Calcium-Activated Potassium Channels Niacinamide Oxygen Permeability Symporters
Alexandre J Kabla
Jul 02, 2012
A number of biological processes, such as embryo development, cancer metastasis or wound healing, rely on cells moving in concert. The mechanisms leading to the emergence of coordinated motion remain however largely unexplored....
The Macronuclear Genome of $\textit{Stentor coeruleus}$ Reveals Tiny Introns in a Giant Cell
MM Slabodnick, JG Ruby, SB Reiff, EC Swart, S Gosai, S Prabakaran, E Witkowska, GE Larue, S Fisher, RM Freeman, J Gunawardena, W Chu, NA Stover, BD Gregory, M Nowacki, J Derisi, SW Roy, WF Marshall, P Sood
Apr 12, 2017
Transcriptional networks controlling the cell cycle.
Martin Bonke, Mikko Turunen, Maria Sokolova, Anna Vähärautio, Teemu Kivioja, Minna Taipale, Mikael Björklund, Jussi Taipale
Nov 04, 2020
In this work, we map the transcriptional targets of 107 previously identified Drosophila genes whose loss caused the strongest cell-cycle phenotypes in a genome-wide RNA interference screen and mine the resulting data...
Animals CDC2 Protein Kinase Cell Cycle Cell Line Cell Size Chromatin Immunoprecipitation Cluster Analysis Drosophila Feedback Physiological Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Microarray Analysis Mitosis Oligonucleotides Phosphorylation RNA Interference Sequence Analysis RNA
Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.
Malgorzata S Martin-Gronert, Denise S Fernandez-Twinn, Martin Bushell, Kenneth Siddle, Susan E Ozanne
Aug 09, 2017
Adipose Tissue Cell-autonomous mechanisms developmental programming Insulin signalling Low birthweight maternal diet Protein restriction Type 2 diabetes Adipocytes Adipose Tissue Animals Cell Size Cells Cultured Diet Protein-Restricted Female Insulin Insulin Resistance Male Maternal Nutritional Physiological Phenomena MicroRNAs Pregnancy Rats Signal Transduction
A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue
Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.
Adipose Tissue Cell-autonomous mechanisms developmental programming Insulin signalling Low birthweight maternal diet Protein restriction Type 2 diabetes Adipocytes Adipose Tissue Animals Cell Size Cells Cultured Diet Protein-Restricted Female Insulin Insulin Resistance Male Maternal Nutritional Physiological Phenomena MicroRNAs Pregnancy Rats Signal Transduction
The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia.
Red cells from patients with sickle cell anemia (SCA) are under greater oxidative challenge than those from normal individuals. We postulated that oxidants generated by xanthine oxidase (XO) and hypoxanthine (HO) contribute to...
Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing.
Benjamin Lacroix, Gaëlle Letort, Laras Pitayu, Jérémy Sallé, Marine Stefanutti, Gilliane Maton, Anne-Marie Ladouceur, Julie C Canman, Paul S Maddox, Amy S Maddox, Nicolas Minc, François Nédélec, Julien Dumont
Jan 26, 2021
Successive cell divisions during embryonic cleavage create increasingly smaller cells, so intracellular structures must adapt accordingly. Mitotic spindle size correlates with cell size, but the mechanisms for this scaling...
Caenorhabditis elegans Paracentrotus lividus Cell Division Embryonic Development in silico models intracellular scaling microtubule dynamics Microtubules mitotic spindle spindle assembly Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Carrier Proteins Cell Size Embryo Nonmammalian Microtubules Paracentrotus Spindle Apparatus
Membrane Mechanics of Endocytosis in Cells with Turgor.
Endocytosis is an essential process by which cells internalize a piece of plasma membrane and material from the outside. In cells with turgor, pressure opposes membrane deformations, and increases the amount of force that has to...
Limits and Constraints on Mechanisms of Cell-Cycle Regulation Imposed by Cell Size-Homeostasis Measurements.
Physical principles of membrane remodelling during cell mechanoadaptation.
Anita Joanna Kosmalska, Laura Casares, Alberto Elosegui-Artola, Joseph Jose Thottacherry, Roberto Moreno-Vicente, Víctor González-Tarragó, Miguel Ángel Del Pozo, Satyajit Mayor, Marino Arroyo, Daniel Navajas, Xavier Trepat, Nils C Gauthier, Pere Roca-Cusachs
Jan 06, 2020
Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell...
The self-organization of plant microtubules inside the cell volume yields their cortical localization, stable alignment, and sensitivity to external cues.
Vincent Mirabet, Pawel Krupinski, Olivier Hamant, Elliot M Meyerowitz, Henrik Jönsson, Arezki Boudaoud
Apr 27, 2018
Many cell functions rely on the ability of microtubules to self-organize as complex networks. In plants, cortical microtubules are essential to determine cell shape as they guide the deposition of cellulose microfibrils, and...
Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease.
Claire M Lye, Guy B Blanchard, Huw W Naylor, Leila Muresan, Jan Huisken, Richard J Adams, Bénédicte Sanson
Oct 07, 2015
Animals Biomarkers Cell Shape Cell Size Drosophila Drosophila Proteins Embryo Nonmammalian Endoderm Gastrulation Green Fluorescent Proteins Mechanical Phenomena Membrane Fusion Proteins Microscopy Electron Scanning Microscopy Video Models Anatomic Morphogenesis Mutation Recombinant Fusion Proteins Rheology Time-Lapse Imaging Twist-Related Protein 1
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume
S Zou, AM Teixeira, M Kostadima, WJ Astle, A Radhakrishnan, LM Simon, L Truman, JS Fang, J Hwa, P-X Zhang, P van der Harst, PF Bray, WH Ouwehand, M Frontini, DS Krause
Aug 07, 2017
Sodium homeostasis in the tumour microenvironment.
Theresa K Leslie, Andrew D James, Fulvio Zaccagna, James T Grist, Surrin Deen, Aneurin Kennerley, Frank Riemer, Joshua D Kaggie, Ferdia A Gallagher, Fiona J Gilbert, William J Brackenbury
Aug 02, 2019
The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and...
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