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The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.
A Communication Theoretical Modeling of Axonal Propagation in Hippocampal Pyramidal Neurons.
Understanding the fundamentals of communication among neurons, known as neuro-spike communication, leads to reach bio-inspired nanoscale communication paradigms. In this paper, we focus on a part of neuro-spike communication...
Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth.
Hafsa Munir, James O Jones, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P Martins, Sarah J Welsh, Jacqueline D Shields
Jan 05, 2021
Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators. Neutrophils release histone-bound nuclear DNA...
Amyloid Precursor Protein Secretases Amyloid beta-Peptides Animals Bone Marrow CD11b Antigen Cancer-Associated Fibroblasts Carcinogenesis Cell Communication Disease Models Animal Extracellular Traps Female Healthy Volunteers Humans Male Mice Mice Transgenic Neoplasms Neutrophils Observational Studies as Topic Primary Cell Culture Prognosis Protein-Arginine Deiminase Type 4 Reactive Oxygen Species Tumor Cells Cultured Tumor Microenvironment
Single cell atlas for 11 non-model mammals, reptiles and birds.
Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Xiran Wang, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai, Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu, Xinghuai Sun, Shenghai Zhang, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu, Yan Hua, Yahong Liu, Huan Liu, Xun Xu
Dec 24, 2021
The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the...
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.
Gurman Kaur, Caroline BM Porter, Orr Ashenberg, Jack Lee, Samantha J Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E Attfield, Christiane AE Desel, Jessica L Davies, Hayley G Evans, Inbal Avraham-Davidi, Lan T Nguyen, Danielle A Dionne, Anna E Neumann, Lise Torp Jensen, Thomas R Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Sep 02, 2022
Fetal growth restriction (FGR) affects 5-10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies...
C5a anaphylatoxin and its role in critical illness-induced organ dysfunction.
Alexander Jt Wood, Arlette Vassallo, Charlotte Summers, Edwin R Chilvers, Andrew Conway-Morris
Nov 19, 2018
C5a complement Critical Illness immunosuppression Infection neutrophil Anaphylatoxins Blood Coagulation Blood Platelets cardiovascular system Cell Communication Complement C5a Critical Illness Endothelium Vascular Humans Immune System Diseases Immunity Innate Multiple Organ Failure Receptor Anaphylatoxin C5a
Platelet P-selectin triggers rapid surface exposure of tissue factor in monocytes.
Tissue factor (TF) plays a central role in haemostasis and thrombosis. Following vascular damage, vessel wall TF initiates the extrinsic coagulation cascade. TF can also be exposed by monocytes. Inflammatory or infectious...
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.
Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M Glover, Magdalena Zernicka-Goetz
Jul 17, 2019
Animals Cell Communication Cell Differentiation Cell Line Cell Lineage Cell Movement Coculture Techniques Embryo Mammalian Endoderm Epithelial-Mesenchymal Transition Gastrulation Gene Expression Regulation Developmental Gestational Age Mice Mouse embryonic stem cells Phenotype Transcriptome Trophoblasts
Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging.
Maiara S Severo, Jonathan JM Landry, Randall L Lindquist, Christian Goosmann, Volker Brinkmann, Paul Collier, Anja E Hauser, Vladimir Benes, Johan Henriksson, Sarah A Teichmann, Elena A Levashina
May 14, 2019
Mosquito blood cells are immune cells that help control infection by vector-borne pathogens. Despite their importance, little is known about mosquito blood cell biology beyond morphological and functional criteria used for their...
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.
Activation of T lymphocytes by peptide/major histocompatibility complex on antigen-presenting cells (APCs) involves dynamic contacts between the two cells, during which T cells undergo marked morphological changes. These...
Actin Depolymerizing Factors Animals Antigen-Presenting Cells CD4-Positive T-Lymphocytes Cell Adhesion Cell Communication Cell Movement Cell Shape Class I Phosphatidylinositol 3-Kinases Dendritic Cells GTP-Binding Proteins Intercellular Adhesion Molecule-1 Lymph Nodes Lymphocyte Function-Associated Antigen-1 Mice Inbred C57BL Phosphatidylinositol 3-Kinases Protein Binding Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell
Photoperiodic control of seasonal growth is mediated by ABA acting on cell-cell communication
S Tylewicz, A Petterle, S Marttila, P Miskolczi, A Azeez, RK Singh, J Immanen, N Mähler, TR Hvidsten, DM Eklund, JL Bowman, YE Helariutta, RP Bhalerao
Apr 29, 2019
In temperate and boreal ecosystems, seasonal cycles of growth and dormancy allow perennial plants to adapt to winter conditions. We show, in hybrid aspen trees, that photoperiodic regulation of dormancy is mechanistically...
Intercellular network structure and regulatory motifs in the human hematopoietic system.
Wenlian Qiao, Weijia Wang, Elisa Laurenti, Andrei L Turinsky, Shoshana J Wodak, Gary D Bader, John E Dick, Peter W Zandstra
Aug 28, 2020
The hematopoietic system is a distributed tissue that consists of functionally distinct cell types continuously produced through hematopoietic stem cell (HSC) differentiation. Combining genomic and phenotypic data with...
Manipulating leukocyte interactions in vivo through optogenetic chemokine release.
Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration.
Jo Richardson, Anton Gauert, Luis Briones Montecinos, Lucía Fanlo, Zainalabdeen Mohmammed Alhashem, Rodrigo Assar, Elisa Marti, Alexandre Kabla, Steffen Härtel, Claudia Linker
May 24, 2016
Alexandre J Kabla
Jul 02, 2012
A number of biological processes, such as embryo development, cancer metastasis or wound healing, rely on cells moving in concert. The mechanisms leading to the emergence of coordinated motion remain however largely unexplored....
M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation.
Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang
Nov 09, 2020
Rationale: For intravascular stent implantation to be successful, the processes of vascular tissue repair and therapy are considered to be critical. However, the mechanisms underlying the eventual fate of vascular smooth muscle...
M2 macrophage Dedifferentiation Exosomes intravascular stent Stiffness vascular smooth muscle cell Animals Cell Communication Cell Differentiation Cell Line Coronary Disease Disease Models Animal Endovascular Procedures Exosomes Humans MACROPHAGES Male Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Proto-Oncogene Proteins c-jun Proto-Oncogene Proteins c-kit RNA-seq Rats Rats Sprague-Dawley Signal Transduction Stents Transcription Factor AP-1
New models to study vascular mural cell embryonic origin
A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells (SMCs) and pericytes influences vessel properties, in particular the regional propensity to vascular diseases....
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A Lazarus, Mona Shehata, Bruno M Simões, Alice R Greenhalgh, Sacha J Howell, Robert B Clarke, Carlos Caldas, Timotheus YF Halim, John C Marioni, Walid T Khaled
Feb 12, 2021
It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known...
Interleukin-15 and interferon-gamma participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production.
Isidoro González-Alvaro, Carmen Domínguez-Jiménez, Ana M Ortiz, Vanessa Núñez-González, Pedro Roda-Navarro, Elena Fernández-Ruiz, David Sancho, Francisco Sánchez-Madrid
Jun 14, 2011
How Subclonal Modeling Is Changing the Metastatic Paradigm
Intestinal epithelial cells
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to...
Phloem development
Phloem, as a major tissue mediating long-distance communication, has been an object of extensive research ever since its structure was first reported in 1837. Functional phloem consists of sieve elements (SEs) and companion...
Entosis Controls a Developmental Cell Clearance in C. elegans.
Yongchan Lee, Jens C Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M Collinson, Cole M Haynes, Oliver Florey, Michael Overholtzer
Jun 25, 2019
Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a...
The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.
Dong Lu, Rinako Nakagawa, Sandra Lazzaro, Philipp Staudacher, Cei Abreu-Goodger, Tom Henley, Sara Boiani, Rebecca Leyland, Alison Galloway, Simon Andrews, Geoffrey Butcher, Stephen L Nutt, Martin Turner, Elena Vigorito
Jul 19, 2018
A single microRNA (miRNA) can regulate the expression of many genes, though the level of repression imparted on any given target is generally low. How then is the selective pressure for a single miRNA/target interaction...
3' Untranslated Regions Animals Antibody Formation B-Lymphocytes Base Sequence Binding Sites Cell Adhesion Cell Communication Cell Differentiation Gene Expression Regulation Lymphocyte Activation lymphopoiesis Mice Mice Knockout MicroRNAs Myelopoiesis PAX5 Transcription Factor Positive Regulatory Domain I-Binding Factor 1 Proto-Oncogene Proteins T-Lymphocytes Trans-Activators Transcription Factors
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