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The calcium transporter ANNEXIN1 mediates cold-induced calcium signaling and freezing tolerance in plants.
Qiangbo Liu, Yanglin Ding, Yiting Shi, Liang Ma, Yi Wang, Chunpeng Song, Katie A Wilkins, Julia M Davies, Heather Knight, Marc R Knight, Zhizhong Gong, Yan Guo, Shuhua Yang
Jan 05, 2021
The transient elevation of cytosolic free calcium concentration ([Ca2+ ]cyt ) induced by cold stress is a well-established phenomenon; however, the underlying mechanism remains elusive. Here, we report that the Ca2+ -permeable...
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Olivia JS Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J Savill, Svenja Hester, Sophie Ravel, Jack D Sunter, Camilla Trevor, Steven Rust, Tristan J Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C Taylor, Matthew K Higgins, Mark Carrington
Feb 19, 2020
Editorial overview
Membrane proteins are associated with or integrated in membranes of cells and organelles, where they fulfil many functions vital for cellular physiology. They transport solutes across membranes to provide building blocks for...
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes.
Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, Lauren McGinney, Jerome Boulanger, Ksenia Rostislavleva, Christopher M Johnson, Izabella Niewczas, Jonathan Clark, Roger L Williams
Jun 30, 2020
The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various complexes that help adapt it to specific pathways, with...
Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.
Michael P Weekes, Robin Antrobus, Suzanne Talbot, Simon Hör, Nikol Simecek, Duncan L Smith, Stuart Bloor, Felix Randow, Paul J Lehner
May 29, 2019
The endoplasmic reticulum chaperone gp96 is required for the cell surface expression of a narrow range of proteins, including toll-like receptors (TLRs) and integrins. To identify a more comprehensive repertoire of proteins...
Animals Antigens CD Cell Line Cell Membrane Chromatography High Pressure Liquid Down-Regulation Integrins Low Density Lipoprotein Receptor-Related Protein-6 Membrane Glycoproteins Membrane Proteins Mice Peptide Fragments Protein Interaction Mapping Proteomics Receptors LDL Tandem Mass Spectrometry Toll-Like Receptors
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.
Christian M Gawden-Bone, Gordon L Frazer, Arianne C Richard, Claire Y Ma, Katharina Strege, Gillian M Griffiths
Oct 03, 2018
CTLs PI(4 5)P2 PIP5K cytotoxic T lymphocytes immunological synapse phosphatidylinositol 4-phosphate 5-kinase phosphoinositides phosphatidylinositol 4 5-biphosphate Phospholipids primary cilia secretion Actins Animals Cell Degranulation Cell Line Cell Membrane Cytoplasmic Granules Cytotoxicity Immunologic Immunological Synapses Lymphocyte Activation Mice Mice Inbred C57BL Mice Transgenic Phosphatidylinositols Phosphotransferases (Alcohol Group Acceptor) Receptors Antigen T-Cell Signal Transduction T-Lymphocytes Cytotoxic
Caveolae protect endothelial cells from membrane rupture during increased cardiac output.
Jade PX Cheng, Carolina Mendoza-Topaz, Gillian Howard, Jessica Chadwick, Elena Shvets, Andrew S Cowburn, Benjamin J Dunmore, Alexi Crosby, Nicholas W Morrell, Benjamin J Nichols
Jun 19, 2018
Caveolae are strikingly abundant in endothelial cells, yet the physiological functions of caveolae in endothelium and other tissues remain incompletely understood. Previous studies suggest a mechanoprotective role, but whether...
Strigolactone can promote or inhibit shoot branching by triggering rapid depletion of the auxin efflux protein PIN1 from the plasma membrane.
Plants continuously extend their root and shoot systems through the action of meristems at their growing tips. By regulating which meristems are active, plants adjust their body plans to suit local environmental conditions. The...
Arabidopsis Arabidopsis Proteins Biological Transport Cell Membrane Clathrin Computer Simulation Gene Expression Regulation Plant Heterocyclic Compounds 3-Ring Indoleacetic Acids Lactones Membrane Transport Proteins Meristem Plant Growth Regulators Plant Roots Plant Shoots Plant Stems Signal Transduction Xylem
Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.
Samuel G Chamberlain, Andrea Gohlke, Arooj Shafiq, Iolo J Squires, Darerca Owen, Helen R Mott
Aug 09, 2021
RalA is a small GTPase and a member of the Ras family. This molecular switch is activated downstream of Ras and is widely implicated in tumor formation and growth. Previous work has shown that the ubiquitous Ca2+-sensor...
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity.
Bo Meng, Adam Abdullahi, Isabella ATM Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L Mallery, Oscar J Charles, CITIID-NIHR BioResource COVID-19 Collaboration, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C Walls, Laurelle Jackson, Darren Martin, Kenneth GC Smith, John Bradley, John AG Briggs, Jinwook Choi, Elo Madissoon, Kerstin B Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A Teichmann, Andrew J Fisher, Matteo S Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J Matheson, Kei Sato, Ravindra K Gupta
Mar 31, 2022
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its...
Adult Aged Aged 80 and over Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral covid-19 COVID-19 Vaccines Cell Line Cell Membrane Chlorocebus aethiops Convalescence Female Humans Immune Sera Intestines Lung Male Membrane Fusion Middle Aged Mutation Nasal Mucosa SARS-CoV-2 Serine Endopeptidases Spike Glycoprotein Coronavirus Tissue Culture Techniques Virulence Virus Internalization Virus Replication
Structure of a cholinergic cell membrane.
Nigel Unwin
Aug 23, 2022
Cell membranes are complex assemblies of proteins and lipids making transient or long-term associations that have yet to be characterized at a molecular level. Here, cryo-electron microscopy is applied to determine how...
Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10
Wei Li, Jingxu Guo, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard Salmon, Randy Read, Nick Morrell, Peter Ten Dijke, Bin Liu
Jun 07, 2022
Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is...
Outer membrane β-barrel protein folding is physically controlled by periplasmic lipid head groups and BamA.
Dennis Gessmann, Yong Hee Chung, Emily J Danoff, Ashlee M Plummer, Clifford W Sandlin, Nathan R Zaccai, Karen G Fleming
Jul 04, 2016
beta-barrel transmembrane protein membrane protein folding Bacterial Outer Membrane Proteins Biocatalysis Cell Membrane Escherichia coli Escherichia coli Proteins Kinetics Lipids Models Biological Periplasm Phenylalanine Phosphatidylethanolamines Phosphatidylglycerols Protein Folding Protein Structure Secondary
Generic membrane spanning features endow IRE1α with responsiveness to membrane aberrancy
Animals CHO Cells Cell Membrane Cricetulus DNA-Binding Proteins Endoplasmic Reticulum Endoplasmic reticulum stress Endoribonucleases Lipids Membrane Proteins Membranes Mutation Palmitic Acid Protein Domains Protein Folding Protein Serine-Threonine Kinases Signal Transduction Transcription Factors Unfolded Protein Response eIF-2 Kinase
Biomimetic Electronic Devices for Measuring Bacterial Membrane Disruption.
Charalampos Pitsalidis, Anna-Maria Pappa, Mintu Porel, Christine M Artim, Gregorio C Faria, Duc D Duong, Christopher A Alabi, Susan Daniel, Alberto Salleo, Róisín M Owens
Sep 17, 2018
TAPBPR
TAPBPR/TAPBPL antigen processing and presentation disease association human major histocompatibility complex (MHC) tapasin Amino Acid Sequence Antigen Presentation Antigen-Presenting Cells Cell Membrane Endoplasmic Reticulum Gene Expression Histocompatibility Antigens Class I Humans Immunoglobulins Membrane Proteins Membrane Transport Proteins Models Molecular Molecular Sequence Data Peptides Protein Transport Signal Transduction
Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L Seifert, Marshall W Hogarth, Davi A Mazala, Kai Ting Huang, Rita Horvath, Jyoti K Jaiswal, György Hajnóczky
Apr 21, 2020
Muscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix...
Atrophy autosomal recessive Calcium Injury membrane Mitochondria mitochondrial disease muscle disease Adolescent Adult Animals Calcium Calcium Signaling Calcium-Binding Proteins Cation Transport Proteins Cell Membrane Cytosol Female FIBROBLASTS Homeostasis Humans Male Mice Knockout Mitochondria Mitochondrial Membrane Transport Proteins Models Biological Muscle Contraction Muscle Weakness Muscle Skeletal Muscular Atrophy Sarcolemma Tetanus Wasting Syndrome
Controlling aggregation of cholesterol-modified DNA nanostructures.
Alexander Ohmann, Kerstin Göpfrich, Himanshu Joshi, Rebecca F Thompson, Diana Sobota, Neil A Ranson, Aleksei Aksimentiev, Ulrich F Keyser
Oct 08, 2019
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.
Caroline Coombs, Antonios Georgantzoglou, Hazel A Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Oct 17, 2019
Immune cells congregate at specific loci to fight infections during inflammatory responses, a process that must be transient and self-resolving. Cell dispersal promotes resolution, but it remains unclear how transition from...
Filopodia and their links with membrane traffic and cell adhesion.
JL Gallop
Dec 09, 2019
Filopodia are dynamic, narrow, plasma membrane protrusions filled with bundled actin filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell body, where barbed end polymerases such as formins and...
Membrane curvature in cell biology
Curving biological membranes establishes the complex architecture of the cell and mediates membrane traffic to control flux through subcellular compartments. Common molecular mechanisms for bending membranes are evident in...
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