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Chromatography DEAE Membranes Micro-capillary films Weak anion-exchange Adsorption Anions Chemistry Techniques Analytical Chromatography Affinity Electrophoresis Polyacrylamide Gel Muramidase Proteins Serum Albumin Bovine Solutions spectroscopy Fourier Transform Infrared

continuous processing flow reactors integrated systems synthetic methods Amantadine Carboxylic Acids Chemistry Techniques Synthetic Equipment Design

Amino Acids Animals Chemistry Techniques Synthetic Humans Proteins Transition Elements

CH functionalization flow chemistry metal catalysis natural products total synthesis Carbazoles Chemistry Techniques Synthetic Hydrogen Bonding Indoles Molecular Structure Pyrroles

Macrocycles have long been recognized as useful chemical entities for medicine, with naturally occurring and synthetic macrocycles clinically approved for use as prescription drugs. Despite this promise, the synthesis of...

Chemistry Techniques Synthetic Cyclization Cycloaddition Reaction Macrocyclic Compounds Small Molecule Libraries

There is evidence to suggest that increasing the level of saturation (that is, the number of sp3-hybridized carbon atoms) of small molecules can increase their likelihood of success in the drug discovery pipeline1. Owing to...

Alkenes Alkylation Amines Carbon Catalysis Chemistry Techniques Synthetic Pharmaceutical Preparations Photochemical Processes

Amides Chemistry Techniques Synthetic Kinetics Manganese Compounds Oxazoles Oxidation-Reduction Oxides

5-(Alkynyl)dibenzothiophenium triflates are introduced as new reagents to prepare different protein conjugates through site-selective cysteine alkynylation. The protocol developed allows a highly efficient label of free...

Alkynes Animals Chemistry Techniques Synthetic Cysteine Humans Indicators and Reagents Mesylates Models Molecular Proteins Sulfhydryl Compounds Thiophenes

In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors. In the rapidly changing...

machine-assisted synthesis sustainable chemistry synthetic methods Biotechnology Chemistry Techniques Synthetic Humans Macromolecular Substances

Eukaryotic translation initiation factor 4E (eIF4E) is considered as the corner stone in the cap-dependent translation initiation machinery. Its role is to recruit mRNA to the ribosome through recognition of the 5'-terminal mRNA...

Cancer Cap-binding inhibitor protein synthesis eIF4E mRNA translation Animals Biomimetic Materials Chemistry Techniques Synthetic Drug Design Eukaryotic Initiation Factor-4E Models Molecular Nucleotides Protein Conformation RNA Caps Rabbits Thiourea

continuous synthesis flow chemistry self-optimization Analgesics Opioid Anesthetics Local Antidepressive Agents Second-Generation Bupropion Chemistry Techniques Synthetic Cloud Computing Drug Industry Equipment Design Japan Lidocaine Tramadol United Kingdom United States

The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp). Combining...

Aminoacyltransferases Bacterial Proteins Biophysical Phenomena Chemistry Techniques Analytical Cysteine Endopeptidases Cytochromes c Electrophoresis Polyacrylamide Gel Heme Kinetics Maltose Maltose-Binding Proteins Point Mutation Protein Binding Protein Denaturation Protein Folding Protein Stability Protein Structure Tertiary Protein Unfolding Proteins Proteolysis Reproducibility of Results Temperature Thermolysin

The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3-9. Arguably the most robust...

Aldehydes Amines Loratadine Alkylation Amination Chemistry Techniques Synthetic

Amyloid beta-Peptides Biflavonoids Chemistry Techniques Synthetic Peptide Fragments Protein Aggregates