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A Randomised, Double-Blind, Placebo-Controlled Trial Evaluating Concentrated Phytochemical-Rich Nutritional Capsule in Addition to a Probiotic Capsule on Clinical Outcomes among Individuals with COVID-19—The UK Phyto-V Study
Gut microflora dysbiosis affects the majority of individuals after COVID-19, contributing to both gastro-intestinal (GI) and non-GI symptoms. Natural phytochemicals have reported anti-viral properties and favourable...
Robert Thomas, Madeleine Williams, Jeffrey Aldous, Yuuki Yanagisawa, Rajeev Kumar, Rachel Forsyth, Angel Chater
Mar 28, 2022
Understanding causes of and developing effective interventions for schizophrenia and other psychoses
Jesus Perez, Debra A Russo, Jan Stochl, Gillian F Shelley, Carolyn M Crane, Michelle Painter, James B Kirkbride, Tim J Croudace, Peter B Jones
Apr 08, 2016
Cognitive training for freezing of gait in Parkinson's disease
Courtney C Walton, Loren Mowszowski, Moran Gilat, Julie M Hall, Claire O'Callaghan, Alana J Muller, Matthew Georgiades, Jennifer YY Szeto, Kaylena A Ehgoetz Martens, James M Shine, Sharon L Naismith, Simon JG Lewis
Sep 05, 2018
The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in...
1103 Clinical Sciences Clinical Clinical Medicine and Science aging Mind and Body Neurosciences Neurodegenerative Clinical Research Brain Disorders Parkinson's Disease Behavioral and Social Science Acquired Cognitive Impairment Mental Health Clinical Trials and Supportive Activities Neurological 6.6 Psychological and behavioural
Corticosteroid tapering with benralizumab treatment for eosinophilic asthma
Andrew Menzies-Gow, Jonathan Corren, Elisabeth H Bel, Jorge Maspero, Liam G Heaney, Mark Gurnell, Peter Wessman, Ubaldo J Martin, Shahid Siddiqui, Esther Garcia Gil
Dec 16, 2019
Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody approved in several countries for the add-on maintenance treatment of patients with severe eosinophilic asthma aged 12 years and older. In the...
Are biologics more effective than corticosteroids for intra‐articular treatment of osteoarthritis?
Summary: Intra‐articular corticosteroids are an effective treatment for equine osteoarthritis, however, there is increasing evidence for the effectiveness of other treatments such as biologics. Whilst current evidence does...
Tracking Repeat Victimisation After Domestic Abuse Cases Are Heard With and Without Independent Domestic Violence Advisors (IDVAs) in an English Magistrate’s Court
Abstract
Research Question
Do cases heard in a specialist domestic abuse (SDA) court on days when Independent Domestic Violence...
Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial).
Stuart Little, Thomas Chadwick, Pratik Choudhary, Cath Brennand, Julia Stickland, Shalleen Barendse, Tolulope Olateju, Lalantha Leelarathna, Emma Walkinshaw, Horng K Tan, Sally M Marshall, Reena M Thomas, Simon Heller, Mark Evans, David Kerr, Daniel Flanagan, Jane Speight, James Am Shaw
Jan 25, 2013
Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people
Francis M Finucane, Jessica Horton, Lisa R Purslow, David B Savage, Soren Brage, Hervé Besson, Kenneth Horton, Ema De Lucia Rolfe, Alison Sleigh, Stephen J Sharp, Helen J Martin, Avan Aihie Sayer, Cyrus Cooper, Ulf Ekelund, Simon J Griffin, Nicholas J Wareham
Jun 16, 2011
1103 Clinical Sciences 1117 Public Health and Health Services Clinical Clinical Medicine and Science aging Cardiovascular Clinical Research obesity Nutrition Prevention Clinical Trials and Supportive Activities Metabolic and endocrine 6.7 Physical 3.1 Primary prevention interventions to modify behaviours or promote well-being
Efficacy of spoken word comprehension therapy in patients with chronic aphasia
Victoria Fleming, Sonia Brownsett, Anna Krason, Maria A Maegli, Henry Coley-Fisher, Yean-Hoon Ong, Davide Nardo, Rupert Leach, David Howard, Holly Robson, Elizabeth Warburton, John Ashburner, Cathy J Price, Jenny T Crinion, Alexander P Leff
Oct 28, 2020
OBJECTIVE: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, 'Listen-In', and examined the relation between brain...
The Stroke Prevention Programme
Background
The management of cardiovascular (CV) risk factors in community populations is suboptimal. The aim of this programme was to explore the role of three approaches [use of a ‘polypill’; self-management of...
Comparative Effectiveness Research Health Services Hypertension Clinical Trials and Supportive Activities Prevention Cost Effectiveness Research Cardiovascular Brain Disorders stroke Clinical Research 7 Management of diseases and conditions 7.3 Management and decision making 7.1 Individual care needs stroke Cardiovascular 3 Good Health and Well Being
Boosted lopinavir vs boosted atazanavir in patients failing a NNRTI first line regimen in an urban clinic in Kampala.
Eva Laker, Ivan Mambule, Damalie Nalwanga, Joseph Musaazi, Agnes Kiragga, Rosalind Parkes-Ratanshi
Apr 09, 2019
INTRODUCTION: In 2011 Uganda recommended boosted atazanavir (ATV/r) as the preferred PI for second line due to once daily dosing, replacing aluvia (LPV/r) (1, 2). The evidence was based on the BMS O45 trial, of LPV/r vs ATV/r...
Standard versus simplified radiofrequency ablation protocol for Barrett's esophagus
Wei Keith Tan, Krish Ragunath, Jonathan R White, Jose Santiago, Jacobo Ortiz Fernandez-Sordo, Mirela Pana, Bincy Alias, Andreas V Hadjinicolaou, Vijay Sujendran, Massimiliano di Pietro
Apr 15, 2019
Interventions for physical activity promotion applied to the primary healthcare settings for people living in regions of low socioeconomic level
Emanuel P Salvador, Evelyn H Ribeiro, Leandro Mt Garcia, Douglas R Andrade, Vanessa Mv Guimaraes, Marcelo S Aoki, Alex A Florindo
Dec 12, 2017
BACKGROUND: Regular physical activity practice has been widely recommended for promoting health, but the physical activity levels remain low in the population. Therefore, the study of interventions to promote physical activity...
What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies.
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring
R Tweyongyere, PA Mawa, M Kihembo, FM Jones, EL Webb, S Cose, DW Dunne, BJ Vennervald, AM Elliott
Sep 23, 2011
Clinical Research Infectious Diseases Vector-Borne Diseases Digestive Diseases Clinical Trials and Supportive Activities Pediatric Infection Inflammatory and immune system Reproductive health and childbirth 3 Good Health and Well Being Animals Antibodies Protozoan Antigens Protozoan Antiprotozoal Agents Cytokines Female Humans Immunity Maternally-Acquired Infant Infant Newborn Leukocytes Mononuclear Placebos Praziquantel Pregnancy Pregnancy Complications Parasitic Schistosoma mansoni Schistosomiasis mansoni Treatment Outcome Uganda
Legal geography 1
This report examines the spatiality of court processes, connecting interdisciplinary work that has considered the physical processes of trials with geographical work that has deepened our understanding of the substance...
Alex Jeffrey
Mar 23, 2018
General practitioners' perceptions of the effectiveness of medical interventions
BACKGROUND: Many interventions shown to be effective through clinical trials are not readily implemented in clinical practice. Unfortunately, little is known regarding how clinicians construct their perceptions of the...
1117 Public Health and Health Services 1103 Clinical Sciences Health services & systems Health Services Research Smoking and Health Cardiovascular Tobacco Clinical Research Comparative Effectiveness Research Brain Disorders Heart Disease Prevention Behavioral and Social Science Mind and Body Clinical Trials and Supportive Activities Cardiovascular Cancer
A school-based, peer-led programme to increase physical activity among 13- to 14-year-old adolescents
Kirsten L Corder, Helen E Brown, Caroline HD Croxson, Stephanie T Jong, Stephen J Sharp, Anna Vignoles, Paul O Wilkinson, Edward Cf Wilson, Esther Mf van Sluijs
May 31, 2021
Background
Adolescent physical activity levels are low and are associated with rising disease risk and social disadvantage. The Get Others Active (GoActive) intervention was co-designed with adolescents and teachers to...
Comparative Effectiveness Research Clinical Research Prevention Behavioral and Social Science Pediatric Clinical Trials and Supportive Activities 3 Prevention of disease and conditions and promotion of well-being 3.1 Primary prevention interventions to modify behaviours or promote wellbeing stroke Cancer Cardiovascular
'Why would they spend all this money and give us these items for free?'
Jane Ardrey, Kate Jehan, Nicola Desmond, Caroline Kumbuyo, Deborah Nyirenda, Stephen B Gordon, Kevin Mortimer, Rachel Tolhurst
Feb 02, 2023
Effects of limiting digital screen use on well-being, mood, and biomarkers of stress in adults
Abstract Studies have linked higher digital screen use with poorer mental health. However, there is limited experimental evidence to suggest a causal relationship. In this trial, we aimed to...
Jesper Pedersen, Martin Gillies Banke Rasmussen, Sarah Overgaard Sørensen, Sofie Rath Mortensen, Line Grønholt Olesen, Søren Brage, Peter Lund Kristensen, Eli Puterman, Anders Grøntved
Oct 12, 2022
ERS International Congress 2021
Thomas Gille, Pradeesh Sivapalan, Georgios Kaltsakas, Shailesh B Kolekar, Matthew Armstrong, Rachel Tuffnell, Rachael A Evans, Guido Vagheggini, Luiza Helena Degani-Costa, Cláudia Vicente, Nilakash Das, Vitalii Poberezhets, Camille Rolland-Debord, Sam Bayat, Ioannis Vogiatzis, Frits ME Franssen, Hilary Pinnock, Lowie EGW Vanfleteren
Jun 29, 2022
It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of laboratory-based science, randomised controlled trials and qualitative...
Intensive therapy for moderate established rheumatoid arthritis
David L Scott, Fowzia Ibrahim, Harry Hill, Brian Tom, Louise Prothero, Rhiannon R Baggott, Ailsa Bosworth, James B Galloway, Sofia Georgopoulou, Naomi Martin, Isabel Neatrour, Elena Nikiphorou, Jackie Sturt, Allan Wailoo, Frances MK Williams, Ruth Williams, Heidi Lempp
Apr 15, 2021
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