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BACKGROUND: Chromosome instability leads to aneuploidy, a state in which cells have abnormal numbers of chromosomes, and is found in two out of three cancers. In a chromosomal instable p53 deficient mouse model with accelerated...

Aneuploidy Copy number detection karyotype heterogeneity leukaemia Lymphoma Single-cell sequencing Aneuploidy Animals chromosomal instability Chromosome Aberrations Comparative Genomic Hybridization Computational Biology DNA Copy Number Variations Genetic Heterogeneity Humans Karyotype Mice Mice Knockout Neoplasms Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Single-Cell Analysis Software

Animals Biological Evolution Comparative Genomic Hybridization Female Fertility Male Sequence Homology Nucleic Acid Sus scrofa X Chromosome Y Chromosome

BACKGROUND: Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is...

Alveolar capillary dysplasia FOXF1 mutation neonate pulmonary hypertension respiratory failure Comparative Genomic Hybridization Forkhead Transcription Factors Genetic Association Studies Humans Infant Infant Newborn Persistent Fetal Circulation Syndrome Poland Pulmonary Alveoli

Adaptation Biological Animals Bacterial Proteins Cattle Comparative Genomic Hybridization DNA Bacterial evolution Molecular Gene Expression Profiling Genes Bacterial Genome Bacterial Genomic Islands Mastitis Bovine Phylogeny Sequence Analysis DNA Streptococcus Virulence

Amino Acid Sequence Animals Comparative Genomic Hybridization Conserved Sequence Drosophilidae evolution Molecular Genome Insect Molecular Sequence Data Multigene Family Sequence Alignment Sequence Analysis DNA Serpins Synteny

Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated...

BRCA1 Breast Cancer classification Copy number aberration profiles Breast Neoplasms Cohort Studies Comparative Genomic Hybridization DNA Methylation Datasets as Topic Female Gene Dosage Genes BRCA1 Humans Randomized Controlled Trials as Topic

Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10-15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination-mediated DNA repair and deficiency...

BRCA1 Breast Cancer Genomic Instability targeted therapy Triple negative breast cancer Adult Aged Aged 80 and over Comparative Genomic Hybridization DNA Methylation DNA Mutational Analysis Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes BRCA1 High-Throughput Nucleotide Sequencing Humans Microarray Analysis Middle Aged Molecular Targeted Therapy Promoter Regions Genetic Transcriptome Triple Negative Breast Neoplasms

Animals Base Sequence Binding Sites Comparative Genomic Hybridization Drosophila Drosophila Proteins evolution Molecular Gene Regulatory Networks Genome principal component analysis Protein Binding Regulatory Elements Transcriptional SOX Transcription Factors Sequence Analysis DNA

Adaptation Physiological Animals Base Sequence Cattle Comparative Genomic Hybridization DNA Bacterial Ecosystem evolution Molecular Genome Bacterial Goats Host-Pathogen Interactions Humans Interspersed Repetitive Sequences Phylogeny Ruminants Sheep Species Specificity Staphylococcus aureus

Base Sequence Breast Neoplasms Cell Line Tumor Chromosome Mapping Cloning Molecular Comparative Genomic Hybridization Female Genome Human Humans Molecular Sequence Data Oncogene Proteins Fusion Sequence Alignment Sequence Analysis DNA

Animals Arthropods Comparative Genomic Hybridization Female In Situ Hybridization Fluorescence Male Real-Time Polymerase Chain Reaction Sex Determination Processes X Chromosome Y Chromosome