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A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a...

ANCA C5a clinical trial complement Therapy Vasculitis Aniline Compounds Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Monoclonal Clinical Trials Phase II as Topic Complement C5a Complement Inactivating Agents Complement Pathway Alternative Humans Neutrophil Activation Nipecotic Acids

BACKGROUND: The mammalian intestine is a complex biological system that exhibits functional plasticity in its response to diverse stimuli to maintain homeostasis. To improve our understanding of this plasticity, we performed a...

Complement Pathway Data integration Homeostasis Intestine pathway analysis transcriptomics Animals Complement Activation Complement System Proteins Computational Biology Gene Expression Profiling Homeostasis Intestinal Mucosa Mice Models Biological Molecular Sequence Annotation Signal Transduction Transcriptome

The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We...

Complement cascade Lectin pathway MBL-associated serine protease Neuroinflammation Neurological deficits Pharmacological target Traumatic brain injury Animals Brain Brain Injuries Traumatic Collectins Complement C4b Complement Pathway Mannose-Binding Lectin Gene Deletion Inflammation Lectins Mannose-Binding Lectin Mannose-Binding Protein-Associated Serine Proteases Mice Mice Knockout Prognosis Recovery of Function

Physiochemical stress induces tissue injury as a result of the detection of abnormal molecular patterns by sensory molecules of the innate immune system. Here, we have described how the recently discovered C-type lectin...

Acute Kidney Injury Animals Collectins Complement Pathway Mannose-Binding Lectin Complement System Proteins Fucose Kidney Tubules Proximal Mannose-Binding Protein-Associated Serine Proteases Mice Mice Knockout

The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its...

Alternative pathway complement Properdin Animals Complement Pathway Alternative History 20th Century History 21st Century Humans Properdin

C3b feedback cycle Factor I complotype Alleles Complement C3b Complement Factor H Complement Pathway Alternative Feedback Physiological Fibrinogen Gene Expression Regulation Genotype Heterozygote Homozygote Humans Peptide Fragments Polymorphism Single Nucleotide Zymosan

Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement...

chronic cerebral hypoperfusion complement Inflammation Microglia white matter injury Animals Brain Injuries Brain Ischemia Complement C3 Complement Pathway Classical Inflammation Male Mice Mice Inbred C57BL Mice Knockout Microglia Perfusion Rats Rats Sprague-Dawley Receptors G-Protein-Coupled white matter

Abstract Background: Complement factor D (FD) is the rate-limiting enzyme of the alternative complement pathway. Previous reports of FD deficiency featured absent plasma FD (type I deficiency) and susceptibility to...

Complement Factor D Complement Pathway Alternative Female Hereditary Complement Deficiency Diseases Humans Immunologic Deficiency Syndromes Male Mutation Pedigree Protein Conformation Young Adult