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Results: 20
Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain).
This paper analyses COVID-19 patients' dynamics during the first wave in the region of Castilla y León (Spain) with around 2.4 million inhabitants using multi-state competing risk survival models. From the date registered as the...
Humans Disease Progression Calibration Hospital Records Confidence Intervals Proportional Hazards Models Probability Reproducibility of Results Comorbidity Adolescent Adult Aged Aged 80 and over Middle Aged Child Child Preschool Infant Infant Newborn Hospitals Primary Health Care Spain Female Male Young Adult covid-19
Published by: PLOS ONE
PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs.
A review of instrumental variable estimators for Mendelian randomization.
instrumental variable Mendelian randomization causal inference comparison of methods finite-sample bias weak instruments Bayes Theorem Case-Control Studies Causality Confidence Intervals genetic variation Humans Least-Squares Analysis Likelihood Functions Mendelian Randomization Analysis Models Statistical Risk Factors
Simultaneous confidence sets for several effective doses.
Construction of simultaneous confidence sets for several effective doses currently relies on inverting the Scheffé type simultaneous confidence band, which is known to be conservative. We develop novel methodology to make the...
Order effects in high stakes undergraduate examinations
Clinical Competence Educational Measurement MEDICAL EDUCATION & TRAINING Adult Clinical Competence Confidence Intervals Education Medical Undergraduate Educational Measurement Female Humans Male Medical History Taking Obstetrics Pediatrics Physical Examination Reproducibility of Results Schools Medical Students Medical United Kingdom
Homozygosity and risk of childhood death due to invasive bacterial disease.
Emily J Lyons, William Amos, James A Berkley, Isaiah Mwangi, Mohammed Shafi, Thomas N Williams, Charles R Newton, Norbert Peshu, Kevin Marsh, J Anthony G Scott, Adrian VS Hill
Jun 14, 2011
BACKGROUND: Genetic heterozygosity is increasingly being shown to be a key predictor of fitness in natural populations, both through inbreeding depression, inbred individuals having low heterozygosity, and also through chance...
Analysis of Variance Bacteremia Case-Control Studies Child Child Preschool Confidence Intervals Genetic Predisposition to Disease Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections Homozygote Humans Infant Infant Newborn Infant Newborn Diseases Kenya Meningitis Bacterial Microsatellite Repeats Odds Ratio Risk Factors
Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models.
Sherly X Li, Roger L Milne, Tu Nguyen-Dumont, Xiaochuan Wang, Dallas R English, Graham G Giles, Melissa C Southey, Antonis C Antoniou, Andrew Lee, Shuai Li, Ingrid Winship, John L Hopper, Mary Beth Terry, Robert J Macinnis
Feb 24, 2021
BACKGROUND: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer risk models are used to provide advice on screening intervals...
Adult Aged Algorithms Breast Neoplasms Confidence Intervals Family Health Female Genetic Predisposition to Disease genetic variation Humans Life Style Medical History Taking Middle Aged Models Statistical Polymorphism Single Nucleotide Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors Time Factors
Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain).
This paper analyses COVID-19 patients' dynamics during the first wave in the region of Castilla y León (Spain) with around 2.4 million inhabitants using multi-state competing risk survival models. From the date registered as the...
Adolescent Adult Aged Aged 80 and over covid-19 Calibration Child Child Preschool Comorbidity Confidence Intervals Disease Progression Female Hospital Records Hospitals Humans Infant Infant Newborn Male Middle Aged Primary Health Care Probability Proportional Hazards Models Reproducibility of Results Spain Young Adult COVID-19 Drug Treatment
Role of the IL-33/ST2 axis in cardiovascular disease
Malaria prevalence and mosquito net coverage in Oromia and SNNPR regions of Ethiopia.
Estifanos B Shargie, Teshome Gebre, Jeremiah Ngondi, Patricia M Graves, Aryc W Mosher, Paul M Emerson, Yeshewamebrat Ejigsemahu, Tekola Endeshaw, Dereje Olana, Asrat WeldeMeskel, Admas Teferra, Zerihun Tadesse, Abate Tilahun, Gedeon Yohannes, Frank O Richards
Jun 16, 2011
Treatment of Multisystem Inflammatory Syndrome in Children.
Andrew J McArdle, Ortensia Vito, Harsita Patel, Eleanor G Seaby, Priyen Shah, Clare Wilson, Claire Broderick, Ruud Nijman, Adriana H Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunnington, Michael Levin, BATS Consortium
Jul 28, 2021
BACKGROUND: Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS: We performed an...
Adolescent Antibodies Viral covid-19 Child Child Preschool Cohort Studies Confidence Intervals Drug Therapy Combination Female Glucocorticoids Hospitalization Humans Immunoglobulins Intravenous immunomodulation Male Propensity Score Regression Analysis Respiration Artificial SARS-CoV-2 Systemic Inflammatory Response Syndrome Treatment Outcome COVID-19 Drug Treatment
Common Susceptibility Loci for Male Breast Cancer.
Sarah Maguire, Eleni Perraki, Katarzyna Tomczyk, Michael E Jones, Olivia Fletcher, Matthew Pugh, Timothy Winter, Kyle Thompson, Rosie Cooke, kConFab Consortium, Alison Trainer, Paul James, Stig Bojesen, Henrik Flyger, Heli Nevanlinna, Johanna Mattson, Eitan Friedman, Yael Laitman, Domenico Palli, Giovanna Masala, Ines Zanna, Laura Ottini, Valentina Silvestri, Antoinette Hollestelle, Maartje J Hooning, Srdjan Novaković, Mateja Krajc, Manuela Gago-Dominguez, Jose Esteban Castelao, Hakan Olsson, Ingrid Hedenfalk, Emmanouil Saloustros, Vasilios Georgoulias, Douglas F Easton, Paul Pharoah, Alison M Dunning, D Timothy Bishop, Susan L Neuhausen, Linda Steele, Alan Ashworth, Montserrat Garcia Closas, Richard Houlston, Anthony Swerdlow, Nick Orr
Oct 16, 2020
BACKGROUND: The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study...
Adjusting for time-varying confounders in survival analysis using structural nested cumulative survival time models.
Accounting for time-varying confounding when assessing the causal effects of time-varying exposures on survival time is challenging. Standard survival methods that incorporate time-varying confounders as covariates generally...
Aalen's additive model G-estimation accelerated failure time model marginal structural model survival data Biometry Computer Simulation Confidence Intervals Confounding Factors Epidemiologic Cystic Fibrosis Deoxyribonucleases Humans Linear Models Models Statistical Proportional Hazards Models Registries Survival Analysis Time Factors United Kingdom
Confidence intervals for the between-study variance in random-effects meta-analysis using generalised heterogeneity statistics
BACKGROUND: Confidence intervals for the between study variance are useful in random-effects meta-analyses because they quantify the uncertainty in the corresponding point estimates. Methods for calculating these confidence...
Correcting for bias in the selection and validation of informative diagnostic tests.
When developing a new diagnostic test for a disease, there are often multiple candidate classifiers to choose from, and it is unclear if any will offer an improvement in performance compared with current technology. A two-stage...
Diagnostic Tests family history group sequential design uniformly minimum variance unbiased estimator Analysis of Variance Bias Biomarkers Breast Neoplasms Computer Simulation Confidence Intervals Early Detection of Cancer Epidemiologic Research Design Family Health Female Humans Likelihood Functions Reproducibility of Results Risk Assessment statistics Nonparametric Surveys and Questionnaires
Handling missing data in matched case-control studies using multiple imputation.
Analysis of matched case-control studies is often complicated by missing data on covariates. Analysis can be restricted to individuals with complete data, but this is inefficient and may be biased. Multiple imputation (MI) is an...
The DAMASK trial protocol
Stephen D Brealey, Christine Atwell, Stirling Bryan, Simon Coulton, Helen Cox, Ben Cross, Fiona Fylan, Andrew Garratt, Fiona J Gilbert, Maureen Gc Gillan, Maggie Hendry, Kerenza Hood, Helen Houston, David King, Veronica Morton, Jo Orchard, Michael Robling, Ian T Russell, David Torgerson, Valerie Wadsworth, Clare Wilkinson
Jan 29, 2020
BACKGROUND: Though new technologies like Magnetic Resonance Imaging (MRI) may be accurate, they often diffuse into practice before thorough assessment of their value in diagnosis and management, and of their effects on patient...
Adolescent Adult Clinical Competence Clinical Protocols Confidence Intervals Family Practice Female Health Services Accessibility Humans Knee Injuries Magnetic Resonance Imaging Male Middle Aged Orthopedics Physical Therapy Specialty Range of Motion Articular Referral and Consultation Research Design Risk Factors United Kingdom
Elevated rates of autism, other neurodevelopmental and psychiatric diagnoses, and autistic traits in transgender and gender-diverse individuals.
Varun Warrier, David M Greenberg, Elizabeth Weir, Clara Buckingham, Paula Smith, Meng-Chuan Lai, Carrie Allison, Simon Baron-Cohen
Jul 16, 2020
Heterogeneity of Associations between Total and Types of Fish Intake and the Incidence of Type 2 Diabetes
Silvia Pastorino, Tom Bishop, Stephen J Sharp, Matthew Pearce, Tasnime Akbaraly, Natalia B Barbieri, Maira Bes-Rastrollo, Joline WJ Beulens, Zhengming Chen, Huaidong Du, Bruce B Duncan, Atsushi Goto, Tommi Härkänen, Maryam Hashemian, Daan Kromhout, Ritva Järvinen, Mika Kivimaki, Paul Knekt, Xu Lin, Eiliv Lund, Dianna J Magliano, Reza Malekzadeh, Miguel Ángel Martínez-González, Gráinne O'Donoghue, Donal O'Gorman, Hossein Poustchi, Charlotta Rylander, Norie Sawada, Jonathan E Shaw, Maria Schmidt, Sabita S Soedamah-Muthu, Liang Sun, Wanqing Wen, Alicja Wolk, Xiao-Ou Shu, Wei Zheng, Nicholas J Wareham, Nita G Forouhi
Apr 19, 2021
The association between fish consumption and new-onset type 2 diabetes is inconsistent and differs according to geographical location. We examined the association between the total and types of fish consumption and type 2...