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Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 08, 2020
INTRODUCTION: Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
HSCs revive their niche after transplantation.
Simón Méndez-Ferrer
Dec 11, 2020
Golan K, Singh AK et al.1 describe how mitochondrial transfer from hematopoietic stem cells (HSCs) to bone marrow (BM) mesenchymal stem cells (MSCs) helps to regenerate the stroma and its capacity to sustain hematopoietic...
Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals.
Hugo Poplimont, Antonios Georgantzoglou, Morgane Boulch, Hazel A Walker, Caroline Coombs, Foteini Papaleonidopoulou, Milka Sarris
May 20, 2020
Neutrophils are major inflammatory cells that rapidly infiltrate wounds to provide antimicrobial functions. Within the damaged tissue, neutrophil migration behavior often switches from exploratory patrolling to coordinated...
Chemotaxis connexins Infection Inflammation leukocyte migration leukotriene Neutrophils Swarming tissue damage Wound Adenosine Triphosphate Animals Calcium Cell Aggregation Connexin 43 connexins Leukotriene B4 Neutrophil Infiltration Neutrophils Pseudomonas aeruginosa Signal Transduction Wounds and Injuries Zebrafish
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Bram P Prins, Timothy J Mead, Jennifer A Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T Klena, George C Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V Smith, Niek Verweij, Helen R Warren, Stefan Weiss, Alvaro Alonso, David O Arnar, Michiel L Bots, Rudolf A de Boer, Anna F Dominiczak, Mark Eijgelsheim, Patrick T Ellinor, Xiuqing Guo, Stephan B Felix, Tamara B Harris, Caroline Hayward, Susan R Heckbert, Paul L Huang, JW Jukema, Mika Kähönen, Jan A Kors, Pier D Lambiase, Lenore J Launer, Man Li, Allan Linneberg, Christopher P Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M Psaty, Olli T Raitakari, Kenneth M Rice, Jerome I Rotter, Moritz F Sinner, Elsayed Z Soliman, Tim D Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G Wilson, Zhijun Xie, Folkert W Asselbergs, Marcus Dörr, Cornelia M van Duijn, Paolo Gasparini, Daniel F Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J Lin, Steven A Lubitz, Dennis O Mook-Kanamori, Francesco J Conti, Christopher H Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J Samani, Gianfranco Sinagra, Blair H Smith, Hilma Holm, Bruno H Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S Apte, Pim van der Harst, Kari Stefansson, Patricia B Munroe, Dan E Arking, Cecilia W Lo, Yalda Jamshidi
Sep 17, 2018
ADAMTS6 Conduction exome chip Meta-Analysis ADAMTS Proteins Animals Black People Connexin 43 Electrocardiography Exome Female Gene Expression Gene Expression Profiling Genetic Loci Genome-Wide Association Study Heart Conduction System Humans Male Mice Middle Aged Myocardium Open Reading Frames Polymorphism Single Nucleotide White People Exome Sequencing
Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation
Rita I Jabr, Fiona S Hatch, Samantha C Salvage, Alejandro Orlowski, Paul D Lampe, Christopher H Fry
May 07, 2019
Cardiac arrhythmias are associated with raised intracellular [Ca2+] and slowed action potential conduction caused by reduced gap junction (GJ) electrical conductance (Gj). Ventricular GJs are composed of connexin proteins...
The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles.
Feifei Ning, Ling Luo, Shiraz Ahmad, Haseeb Valli, Kamalan Jeevaratnam, Tingzhong Wang, Laila Guzadhur, Dandan Yang, James A Fraser, Christopher L-H Huang, Aiqun Ma, Samantha C Salvage
Oct 21, 2015
Soluble silica stimulates osteogenic differentiation and gap junction communication in human dental follicle cells.
Pamela Uribe, Anders Johansson, Ravin Jugdaohsingh, Jonathan J Powell, Catarina Magnusson, Marcela Davila, Anna Westerlund, Maria Ransjö
Jun 18, 2021
Several studies have indicated that dietary silicon (Si) is beneficial for bone homeostasis and skeletal health. Furthermore, Si-containing bioactive glass biomaterials have positive effects on bone regeneration when used for...