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Results: 7
The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Michal Meir, Yaron Galanty, Lior Kashani, Michael Blank, Rami Khosravi, María Jesús Fernández-Ávila, Andrés Cruz-García, Ayelet Star, Lea Shochot, Yann Thomas, Lisa J Garrett, Daniel A Chamovitz, David M Bodine, Thimo Kurz, Pablo Huertas, Yael Ziv, Yosef Shiloh
Jun 01, 2015
Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.
Cullin‐3 ROMK WNK kinases hyperkalemia Proteasome ubiquitin‐ligase complex Adaptor Proteins Signal Transducing Animals Biomarkers Cell Line Cullin Proteins Gene Knock-In Techniques Genetic Predisposition to Disease Kidney Membrane Potentials Mice Transgenic Microfilament Proteins Mutation Oocytes Phenotype Potassium Potassium Channels Inwardly Rectifying Protein Processing Post-Translational Protein Serine-Threonine Kinases Pseudohypoaldosteronism Transfection Xenopus laevis
Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.
BTB–Kelch E3 ubiquitin ligase X-ray crystallography immunosuppression innate immunity isothermal titration calorimetry (ITC) Poxvirus Protein Structure structure-function viral immunology Amino Acid Substitution Cullin Proteins HEK293 Cells Humans Multiprotein Complexes Mutation Missense Protein Domains Protein Structure Quaternary Proteolysis Ubiquitination Vaccinia vaccinia virus Viral Proteins
WNK signalling pathways in blood pressure regulation.
hyperkalemia Hypertension NCC Proteasome SPAK/OSR1 phosphorylation Ubiquitin-E3 ligase complex WNK kinases Animals blood pressure Cullin Proteins Humans Hypertension Neovascularization Physiologic Protein Serine-Threonine Kinases Pseudohypoaldosteronism Receptors Drug Signal Transduction Sodium Chloride Symporters Sodium-Potassium-Chloride Symporters
Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8+ T-Cell Memory.
Mitchell A Pallett, Hongwei Ren, Rui-Yao Zhang, Simon R Scutts, Laura Gonzalez, Zihan Zhu, Carlos Maluquer de Motes, Geoffrey L Smith
Feb 19, 2019
BTB-Kelch E3 ligase NF-κB cullin-3 importins protein A55 vaccinia virus Animals BTB-POZ Domain Cell Line Cullin Proteins Female HEK293 Cells Humans Immune Evasion Immunity Innate Karyopherins Kelch Repeat Mice Mice Inbred C57BL NF-kappa B Poxviridae Signal Transduction T-Lymphocytes Ubiquitin-Protein Ligases Vaccinia vaccinia virus Viral Proteins Virulence Virus Replication alpha Karyopherins
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).
Mark Glover, James S Ware, Amanda Henry, Martin Wolley, Roddy Walsh, Louise V Wain, Shengxin Xu, William G Van't Hoff, Martin D Tobin, Ian P Hall, Stuart Cook, Richard D Gordon, Michael Stowasser, Kevin M O'Shaughnessy
Aug 19, 2014