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5-HT3 Cys-loop receptor ELIC Erwinia PAM Chimera modulator pLGIC

Cys-loop receptor Ligand-gated ion channel serotonin receptor Amino Acid Sequence Animals Binding Sites Carrier Proteins Crystallography X-Ray HEK293 Cells Humans Hydrogen Bonding Mice Models Molecular Mutation Oocytes Patch-Clamp Techniques Protein Structure Secondary Receptors Serotonin 5-HT3 Serotonin Serotonin Agents Varenicline water Xenopus

Cys-loop receptor Gloeobacter violaceus Electrophysiology Mutagenesis non-canonical amino acid non-standard mutagenesis nonsense suppression proline analogs Protein Conformation structure-function Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution Bacterial Proteins Cyanobacteria Hydrogen Bonding Ion Channel Gating Ligand-Gated Ion Channels Models Molecular Molecular Sequence Data Proline Protein Structure Secondary

GABRA2 Cys-loop receptor epileptic encephalopathy protein structural analysis whole-genome sequencing Child Epilepsy Female Humans Ion Channel Gating Language Disorders Molecular Dynamics Simulation Mutation Missense Protein Domains Protein Multimerization Receptors GABA-A Stereotyped Behavior

5-HT3 receptors are members of the family of pentameric ligand gated ion channels (pLGICs). Each subunit has four transmembrane α-helices (M1-M4), with M4 being most distant from the central pore. Residues in this α-helix...

Cys-loop receptor aromatic interaction Binding site Mutagenesis π interaction Amino Acid Sequence Binding Sites HEK293 Cells Humans Models Molecular Mutation Protein Structure Secondary Receptors Serotonin 5-HT3

Cys-loop receptor Binding site Mutagenesis noncanonical amino acid nonsense suppression Amino Acid Sequence HEK293 Cells Humans Membrane Lipids Receptors Serotonin 5-HT3 Serotonin

Cys-loop receptor Ligand-gated ion channel serotonin receptor Animals Aplysia Binding Sites Carrier Proteins Crystallography X-Ray Dose-Response Relationship Drug HEK293 Cells Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Isoquinolines Membrane Potentials Models Molecular Molecular Structure Mutation Protein Engineering Quinuclidines Receptors Serotonin 5-HT3 Serotonin 5-HT3 Receptor Antagonists

$\textit{Gloeobacter}$ Cys-loop receptor pore block Antagonist M2

Cys-loop receptor aromatic interaction Binding site hydrophobic interaction Mutagenesis Alanine Amino Acid Sequence Amino Acids Models Molecular Phylogeny Receptors GABA-A gamma-Aminobutyric Acid

The role of the outermost helix (M4) in the pentameric ligand-gated ion channel (pLGIC) family is currently not fully understood. It is known that M4 is important for receptor assembly, possibly via interactions with neighboring...

Cys-loop receptor M4 aromatic interaction Mutagenesis nACh receptor

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the...

Cys-loop receptor ELIC Electrophysiology Molecular dynamics pentameric ligand-gated ion channel Site-directed mutagenesis Animals cations Cell Line Crystallography X-Ray Humans Ligand-Gated Ion Channels Lipids Models Molecular Oocytes Protein Binding Protein Structural Elements Xenopus laevis

Cys-loop receptor Ligand-gated ion channel serotonin receptor Animals Biguanides Oocytes Receptors Serotonin 5-HT3 Serotonin Serotonin 5-HT3 Receptor Agonists Thymol Tryptamines Varenicline Xenopus laevis