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Results: 20
Stem cell function and stress response are controlled by protein synthesis.
Sandra Blanco, Roberto Bandiera, Martyna Popis, Shobbir Hussain, Patrick Lombard, Jelena Aleksic, Abdulrahim Sajini, Hinal Tanna, Rosana Cortés-Garrido, Nikoletta Gkatza, Sabine Dietmann, Michaela Frye
May 05, 2016
Formation and abundance of 5-hydroxymethylcytosine in RNA.
Sabrina M Huber, Pieter van Delft, Lee Mendil, Martin Bachman, Katherine Smollett, Finn Werner, Eric A Miska, Shankar Balasubramanian
May 12, 2015
5-Formylcytosine can be a stable DNA modification in mammals.
Martin Bachman, Santiago Uribe-Lewis, Xiaoping Yang, Heather E Burgess, Mario Iurlaro, Wolf Reik, Adele Murrell, Shankar Balasubramanian
Jun 11, 2015
5-Hydroxymethylcytosine is a predominantly stable DNA modification.
Martin Bachman, Santiago Uribe-Lewis, Xiaoping Yang, Michael Williams, Adele Murrell, Shankar Balasubramanian
Sep 30, 2014
Cytosine-5 RNA methylation links protein synthesis to cell metabolism.
Nikoletta A Gkatza, Cecilia Castro, Robert F Harvey, Matthias Heiß, Martyna C Popis, Sandra Blanco, Susanne Bornelöv, Abdulrahim A Sajini, Joseph G Gleeson, Julian L Griffin, James A West, Stefanie Kellner, Anne E Willis, Sabine Dietmann, Michaela Frye
May 20, 2019
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
Isabela Cunha Navarro, Francesca Tuorto, David Jordan, Carine Legrand, Jonathan Price, Fabian Braukmann, Alan G Hendrick, Alper Akay, Annika Kotter, Mark Helm, Frank Lyko, Eric A Miska
Nov 12, 2020
Methylation of carbon-5 of cytosines (m5 C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5 C-methyltransferases have been studied, the impact of the global cytosine-5...
Caenorhabditis elegans 5-Methylcytosine NSUN RNA modifications translation efficiency 5-Methylcytosine Adaptation Physiological Animals CRISPR-Cas Systems Caenorhabditis elegans Cytosine Gene Editing Heat-Shock Response Hot Temperature Leucine Methyltransferases Mitochondria Proline Protein Biosynthesis RNA RNA processing Post-Transcriptional Ribosomes
5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells.
Eun-Ang Raiber, Guillem Portella, Sergio Martínez Cuesta, Robyn Hardisty, Pierre Murat, Zhe Li, Mario Iurlaro, Wendy Dean, Julia Spindel, Dario Beraldi, Zheng Liu, Mark A Dawson, Wolf Reik, Shankar Balasubramanian
Nov 30, 2018
Nucleosomes are the basic unit of chromatin that help the packaging of genetic material while controlling access to the genetic information. The underlying DNA sequence, together with transcription-associated proteins and...
Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.
Anne Derache, Collins C Iwuji, Siva Danaviah, Jennifer Giandhari, Anne-Geneviève Marcelin, Vincent Calvez, Tulio de Oliveira, François Dabis, Deenan Pillay, Ravindra K Gupta
Oct 22, 2019
OBJECTIVES: The WHO recently recommended the use of a new first-line ART containing dolutegravir. We investigated the efficacy of NRTI backbones (tenofovir or abacavir with a cytosine analogue) in low- and middle-income...
Adult Anti-HIV Agents Antiretroviral Therapy Highly Active Cytosine Dideoxynucleosides Drug Combinations Drug Resistance Viral Female HIV Infections HIV Integrase Inhibitors HIV-1 Heterocyclic Compounds 3-Ring Humans Male Middle Aged Mutation Oxazines Piperazines Pyridones South Africa Tenofovir Viral Load Young Adult
Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.
John P Thomson, Harri Lempiäinen, Jamie A Hackett, Colm E Nestor, Arne Müller, Federico Bolognani, Edward J Oakeley, Dirk Schübeler, Rémi Terranova, Diana Reinhardt, Jonathan G Moggs, Richard R Meehan
Oct 03, 2012
A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL.
Rubben Torella, Jinghua Li, Eddie Kinrade, Gustavo Cerda-Moya, Ashley N Contreras, Robert Foy, Robert Stojnic, Robert C Glen, Rhett A Kovall, Boris Adryan, Sarah J Bray
Aug 22, 2014
Methods for discovering genomic loci exhibiting complex patterns of differential methylation.
Thomas J Hardcastle
Sep 19, 2017
BACKGROUND: Cytosine methylation is widespread in most eukaryotic genomes and is known to play a substantial role in various regulatory pathways. Unmethylated cytosines may be converted to uracil through the addition of sodium...
Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).
Sarah F Field, Dario Beraldi, Martin Bachman, Sabrina K Stewart, Stephan Beck, Shankar Balasubramanian
Apr 08, 2015
Global analysis of cytosine and adenine DNA modifications across the tree of life.
Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, Christoph B Messner, Nicholas Grayson, Floriana Capuano, Michael Mülleder, Markus Ralser
Sep 02, 2022
Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate...
In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.
Mario Iurlaro, Gordon R McInroy, Heather E Burgess, Wendy Dean, Eun-Ang Raiber, Martin Bachman, Dario Beraldi, Shankar Balasubramanian, Wolf Reik
Jul 27, 2016
Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation.
Abdulrahim A Sajini, Nila Roy Choudhury, Rebecca E Wagner, Susanne Bornelöv, Tommaso Selmi, Christos Spanos, Sabine Dietmann, Juri Rappsilber, Gracjan Michlewski, Michaela Frye
Apr 18, 2019