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Structural insights into the role of domain flexibility in human DNA ligase IV.
Takashi Ochi, Qian Wu, Dimitri Y Chirgadze, J Günter Grossmann, Victor M Bolanos-Garcia, Tom L Blundell
Mar 12, 2021
Knowledge of the architecture of DNA ligase IV (LigIV) and interactions with XRCC4 and XLF-Cernunnos is necessary for understanding its role in the ligation of double-strand breaks during nonhomologous end joining. Here we...
Catalytic Domain Chromatography Gel DNA DNA Breaks Double-Stranded DNA Ligase ATP DNA Ligases DNA Nucleotidyltransferases DNA Repair DNA Repair Enzymes DNA-Binding Proteins Escherichia coli Humans Models Molecular Protein Binding Protein Structure Secondary Protein Structure Tertiary Recombinant Proteins SCATTERING Small Angle X-Ray Diffraction