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Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Camille Samson, Pierre Legrand, Mustafa Tekpinar, Jef Rozenski, Mikhail Abramov, Philipp Holliger, Vitor B Pinheiro, Piet Herdewijn, Marc Delarue
Dec 10, 2020
Archaeal DNA polymerases from the B-family (polB) have found essential applications in biotechnology. In addition, some of their variants can accept a wide range of modified nucleotides or xenobiotic nucleotides, such as...
DNA polymerase Crystallography protein expression and purification structural biology xeno-nucleic acid (XNA) Archaeal Proteins Binding Sites Cloning Molecular Crystallography X-Ray DNA Polymerase beta DNA Archaeal Directed Molecular Evolution Escherichia coli Gene Expression Genetic Vectors Hexosephosphates Kinetics Molecular Dynamics Simulation Mutation Nucleic Acid Conformation Nucleotides Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Engineering Protein Interaction Domains and Motifs RNA Archaeal Substrate Specificity Thermococcus
The DNA polymerases of Drosophila melanogaster.
Steven J Marygold, Helen Attrill, Elena Speretta, Kate Warner, Michele Magrane, Maria Berloco, Sue Cotterill, Mitch McVey, Yikang Rong, Masamitsu Yamaguchi
Jan 09, 2020
DNA synthesis during replication or repair is a fundamental cellular process that is catalyzed by a set of evolutionary conserved polymerases. Despite a large body of research, the DNA polymerases of Drosophila melanogaster have...