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Cell Movement Dictyostelium Extracellular Matrix Mechanotransduction Cellular Pseudopodia Stress Mechanical Weight-Bearing Weights and Measures

Cryoelectron Microscopy Dictyostelium Eukaryotic Initiation Factors GTP Phosphohydrolases Humans Models Biological Models Molecular Molecular Conformation Peptide Chain Initiation Translational Peptide Elongation Factors Proteins Protozoan Proteins Ribonucleoprotein U5 Small Nuclear Ribosome Subunits Large Eukaryotic

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the...

Animals Arabidopsis Caenorhabditis elegans Dictyostelium Drosophila melanogaster Escherichia coli Gene Ontology Humans Internet Mice Molecular Sequence Annotation Rats Saccharomyces cerevisiae Schizosaccharomyces User-Computer Interface Zebrafish

Actins Animals Biological Transport Biopolymers Cell Membrane Cell Movement Cell Polarity Cycloheximide Dictyostelium Phagocytosis Protein Biosynthesis Time Factors

Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins...

Allosteric Regulation Animals Chickens Dictyostelium Hydrocarbons Chlorinated Models Molecular Myosins Pyrroles Rabbits Rats

Animals Dictyostelium Disease Models Animal Gene Expression Profiling Gene Expression Regulation Genome Protozoan Humans Protozoan Proteins Pseudomonas aeruginosa Species Specificity Virulence

4-Hydroxyphenylpyruvate Dioxygenase Blotting Northern Cyclic AMP-Dependent Protein Kinases Cyclin-Dependent Kinase 8 Dictyostelium Fatty Acid Synthases Gene Duplication Microarray Analysis NADH NADPH Oxidoreductases Phenotype Proteomics Spores Protozoan

Germ Cells Cells Cultured Ribosomes Animals Humans Drosophila Dictyostelium Saccharomyces cerevisiae Proteins Ribonucleoprotein U5 Small Nuclear Peptide Elongation Factors Eukaryotic Initiation Factors Biological Phenomena Protein Biosynthesis Protein Binding Sequence Homology Amino Acid Mutation Adolescent Adult Child Child Preschool Infant Ribosome Subunits Large Eukaryotic Young Adult Molecular Dynamics Simulation Shwachman-Diamond Syndrome

Adolescent Adult Animals Biological Phenomena Cells Cultured Child Child Preschool Dictyostelium Drosophila Eukaryotic Initiation Factors Germ Cells Humans Infant Molecular Dynamics Simulation Mutation Peptide Elongation Factors Protein Binding Protein Biosynthesis Proteins Ribonucleoprotein U5 Small Nuclear Ribosome Subunits Large Eukaryotic Ribosomes Saccharomyces cerevisiae Sequence Homology Amino Acid Shwachman-Diamond Syndrome Young Adult

Biomedical Research Dictyostelium Gene Duplication genetic variation Genome

ATP DIF Dictyostelium Polycystin-2 Purinergic signalling TRP channel

Blebs and pseudopods can both power cell migration, with blebs often favored in tissues, where cells encounter increased mechanical resistance. To investigate how migrating cells detect and respond to mechanical forces, we used...

Chemotaxis Dictyostelium cell migration Blebbing piezo

Amino Acid Sequence Animals Cell Aggregation Cyclic AMP-Dependent Protein Kinases DNA Protozoan Dictyostelium Folic Acid Gene Expression Regulation Developmental Genes Protozoan Membrane Proteins Molecular Sequence Data Multigene Family Mutation Phenotype Protozoan Proteins Restriction Mapping Sequence Analysis DNA Signal Transduction Starvation

BioModelAnalyzer (BMA) is an open-source graphical tool for the development of executable models of protein and gene networks within cells. Based upon the Qualitative Networks formalism, the user can rapidly construct large...

Cell Signaling executable models formal verification Systems Biology Cell Cycle Cyclic AMP Dictyostelium Germ Cells Models Biological Models Molecular Signal Transduction Software

Blebs and pseudopods can both power cell migration, with blebs often favored in tissues, where cells encounter increased mechanical resistance. To investigate how migrating cells detect and respond to mechanical forces, we used...

Dictyostelium piezo Blebbing cell migration Chemotaxis Biomechanical Phenomena Cell Movement Cytoplasm Dictyostelium Ion Channels Mechanotransduction Cellular Myosin Type II Pressure Protozoan Proteins Pseudopodia

Dictyostelium discoideum antibacterial compound dibenzofuran differentiation-inducing factor (DIF) polyketide synthase Dibenzofurans Polychlorinated Dictyostelium Ecosystem Fatty Acid Synthases Polyketide Synthases polyketides Soil