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Cover Image for Mutational landscape of a chemically-induced mouse model of liver cancer.

Mutational landscape of a chemically-induced mouse model of liver cancer.

Frances Connor, Tim F Rayner, Sarah J Aitken, Christine Feig, Margus Lukk, Javier Santoyo-Lopez, Duncan T Odom

Oct 10, 2018

Cancer genomics Carcinogen mouse model hepatocellular carcinoma Hras mutational signatures Animals DNA Copy Number Variations Diethylnitrosamine Disease Models Animal Exome Genes ras Liver Neoplasms Experimental Male Mice Mice Inbred C3H Mutation

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Cover Image for Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.

Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, Michael WJ Hall, Agnieszka Wabik, Stefan C Dentro, Joanna C Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A Hall, Philip H Jones

Apr 28, 2020

ADAM10 Protein Amyloid Precursor Protein Secretases Animals Cell Lineage Diethylnitrosamine Epithelium esophagus Female High-Throughput Nucleotide Sequencing Male Membrane Proteins Mice Inbred C57BL Mice Transgenic Mutation Receptor Notch1 Receptor Notch2 Reproducibility of Results Tumor Suppressor Protein p53

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