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Evolution of protein complexes by duplication of homomeric interactions.

Jose B Pereira-Leal, Emmanuel D Levy, Christel Kamp, Sarah A Teichmann

May 16, 2019

BACKGROUND: Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins...

Dimerization evolution Molecular Gene Duplication Models Genetic Models Molecular Multiprotein Complexes Protein Structure Quaternary Protein Subunits Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins

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Cover Image for Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States.

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Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes.

Naomi J Petela, Andres Gonzalez Llamazares, Sarah Dixon, Bin Hu, Byung-Gil Lee, Jean Metson, Heekyo Seo, Antonio Ferrer-Harding, Menelaos Voulgaris, Thomas Gligoris, James Collier, Byung-Ha Oh, Jan Löwe, Kim A Nasmyth

Jul 28, 2021

Cohesin's association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being 'clamped' by Scc2 and ATP-dependent engagement...

S. cerevisiae Chromosomes cryo-EM Folding Gene Expression molecular biophysics sister chromatid cohesion structural biology Adenosine Triphosphatases Cell Cycle Proteins Chromatids Chromosomal Proteins Non-Histone Chromosomes Cryoelectron Microscopy DNA Dimerization Gene Expression Regulation Fungal Hydrolysis Protein Domains Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins

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