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Results: 7
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.
Mélanie A Eckersley-Maslin, Valentine Svensson, Christel Krueger, Thomas M Stubbs, Pascal Giehr, Felix Krueger, Ricardo J Miragaia, Charalampos Kyriakopoulos, Rebecca V Berrens, Inês Milagre, Jörn Walter, Sarah A Teichmann, Wolf Reik
May 16, 2019
Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous...
DNA Methylation MERVL Zscan4 Chromatin Embryonic Stem Cell Endogenous retrovirus imprint preimplantation reprogramming Animals Cell Cycle Cellular Reprogramming Chromatin DNA Methylation DNA Modification Methylases endogenous retroviruses Epigenesis Genetic Genome Genomic Imprinting Induced Pluripotent Stem Cells Mice Mouse embryonic stem cells Multigene Family RNA Messenger Single-Cell Analysis Transcription Factors Transcriptional Activation Transcriptome
Stoyana Alexandrova, Tuzer Kalkan, Peter Humphreys, Andrew Riddell, Roberta Scognamiglio, Andreas Trumpp, Jennifer Nichols
Nov 16, 2015
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis.
Thorsten Boroviak, Remco Loos, Patrick Lombard, Junko Okahara, Rüdiger Behr, Erika Sasaki, Jennifer Nichols, Austin Smith, Paul Bertone
Nov 23, 2015
Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency.
Tüzer Kalkan, Susanne Bornelöv, Carla Mulas, Evangelia Diamanti, Tim Lohoff, Meryem Ralser, Sjors Middelkamp, Patrick Lombard, Jennifer Nichols, Austin Smith
Apr 10, 2019
ETS factors RBPJ Commitment DIFFERENTIATION Embryonic Stem Cell Epiblast gene regulatory network Pluripotency self-renewal Animals Basic Helix-Loop-Helix Transcription Factors Cell Differentiation Cell Line Cell Lineage Cell Self Renewal DNA-Binding Proteins Gene Knockout Techniques Gene Regulatory Networks Immunoglobulin J Recombination Signal Sequence-Binding Protein Mice Mice Inbred C57BL Mice Inbred CBA Nanog Homeobox Protein Neurons Pluripotent Stem Cells RNA Small Interfering T-Box Domain Proteins Transcription Factors
Activation of lineage-regulators and transposable elements across a pluripotent spectrum
DNA Methylation KLF4 PGC STAT3 chimeric transcripts Embryonic Stem Cell Heterogeneity imprints Pluripotency transposable element Animals CRISPR-Cas Systems Cell Differentiation Cell Line Cell Lineage DNA Methylation DNA Transposable Elements GATA4 Transcription Factor Kruppel-Like Factor 4 Kruppel-Like Transcription Factors Leukemia Inhibitory Factor Male Mice Mice Inbred C57BL Mouse embryonic stem cells Pluripotent Stem Cells Positive Regulatory Domain I-Binding Factor 1 principal component analysis SOXB1 Transcription Factors STAT3 Transcription Factor Transcription Factors