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A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.
Silvia Corrochano, Gonzalo Blanco, Debbie Williams, Jessica Wettstein, Michelle Simon, Saumya Kumar, Lee Moir, Thomas Agnew, Michelle Stewart, Allison Landman, Vassilios N Kotiadis, Michael R Duchen, Henning Wackerhage, David C Rubinsztein, Steve DM Brown, Abraham Acevedo-Arozena
Sep 27, 2018
Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine...