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Universal screening for foetal growth restriction.
Gordon CS Smith
Jun 01, 2018
Foetal growth restriction (FGR) is a major cause of morbidity and mortality. Clinical methods for identifying women whose pregnancies are affected by FGR do not perform well. Despite this, the current approach to screening...
biomarker Doppler Foetal growth restriction Placenta screening ULTRASOUND Biomarkers Biometry Female Fetal Growth Retardation Gestational Age Humans Infant Newborn Mass Screening Placenta Predictive Value of Tests Pregnancy Prenatal Care Randomized Controlled Trials as Topic Research Design Risk Factors Ultrasonography Prenatal
Next steps to prevent stillbirth associated with growth restriction.
Despite increasing use of ultrasound in obstetrics, the task of accurately identifying fetuses at risk of stillbirth from chronic placental diseases (Kingdom JC, et al. Am. J. Obstet. Gynecol. 2018;218:S803–17) continues to...
Fetal Growth and the Risk of Spontaneous Preterm Birth in a Prospective Cohort Study of Nulliparous Women.
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.
Gurman Kaur, Caroline BM Porter, Orr Ashenberg, Jack Lee, Samantha J Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E Attfield, Christiane AE Desel, Jessica L Davies, Hayley G Evans, Inbal Avraham-Davidi, Lan T Nguyen, Danielle A Dionne, Anna E Neumann, Lise Torp Jensen, Thomas R Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Sep 02, 2022
Fetal growth restriction (FGR) affects 5-10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies...
Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth.
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Iain P Hargreaves, Viruna Neergheen, Catherine E Aiken, Malgorzata S Martin-Gronert, Josie M McConnell, Susan E Ozanne
Dec 10, 2015
accelerated postnatal growth coenzyme Q developmental programming Liver Disease low birth weight Animals Anti-Inflammatory Agents Non-Steroidal Cytokines Diet Protein-Restricted Dietary Supplements Female Fetal Development Fetal Growth Retardation Hepatitis Hyperinsulinism Liver Liver Cirrhosis Male Malnutrition Maternal Nutritional Physiological Phenomena Oxidative Stress Pregnancy Pregnancy Complications Rats Wistar Specific Pathogen-Free Organisms Ubiquinone Weaning
Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β
Masahito Mizuuchi, Tereza Cindrova-Davies, Matts Olovsson, D Stephen Charnock-Jones, Graham J Burton, Hong Wa Yung
Dec 15, 2015
Endoplasmic reticulum stress Placenta placental growth factor pre-eclampsia pregnancy and reproduction Activating Transcription Factor 4 Activating Transcription Factor 6 Basic-Leucine Zipper Transcription Factors Endoplasmic reticulum stress Female Fetal Growth Retardation Humans Placenta Placenta Growth Factor Pregnancy Pregnancy Complications Pregnancy Proteins Unfolded Protein Response
Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model.
Anna M Nuzzo, Emily J Camm, Amanda N Sferruzzi-Perri, Thomas J Ashmore, Hong-Wa Yung, Tereza Cindrova-Davies, Ana-Mishel Spiroski, Megan R Sutherland, Angela Logan, Shani Austin-Williams, Graham J Burton, Alessandro Rolfo, Tullia Todros, Michael P Murphy, Dino A Giussani
Oct 03, 2018
Molecular genetic investigations identify new clinical phenotypes associated with BCS1L-related mitochondrial disease.
Monika Oláhová, Camilla Ceccatelli Berti, Jack J Collier, Charlotte L Alston, Elisabeth Jameson, Simon A Jones, Noel Edwards, Langping He, Patrick F Chinnery, Rita Horvath, Paola Goffrini, Robert W Taylor, John A Sayer
Sep 04, 2019
BCS1L encodes a homolog of the Saccharomyces cerevisiae bcs1 protein, which has a known role in the assembly of Complex III of the mitochondrial respiratory chain. Phenotypes reported in association with pathogenic BCS1L...
ATPases Associated with Diverse Cellular Activities acidosis Lactic Adult Amino Acid Sequence Cholestasis Electron Transport Complex III Female Fetal Growth Retardation FIBROBLASTS Hemosiderosis Humans Infant Male metabolism Inborn Errors Mitochondrial Diseases Muscle Skeletal Mutation Phenotype Renal Aminoacidurias
Intervention against hypertension in the next generation programmed by developmental hypoxia.
Kirsty L Brain, Beth J Allison, Youguo Niu, Christine M Cross, Nozomi Itani, Andrew D Kane, Emilio A Herrera, Katie L Skeffington, Kimberley J Botting, Dino A Giussani
Jan 21, 2019
Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations.
Clive J Petry, Mark L Evans, Dianne L Wingate, Ken K Ong, Wolf Reik, Miguel Constância, David B Dunger
Oct 03, 2017
Placental Stem Villus Arterial Remodeling Associated with Reduced Hydrogen Sulfide Synthesis Contributes to Human Fetal Growth Restriction.
Adult Allyl Compounds arteries Cell Dedifferentiation Cell Differentiation Cell Hypoxia Chorionic Villi Cystathionine gamma-Lyase Desmin Female Fetal Growth Retardation Gene Expression Regulation Humans Hydrogen Sulfide Matrix Metalloproteinase 2 Myocytes Smooth Muscle Myosin Heavy Chains Oxidative Stress Pregnancy premature birth RNA Messenger Retinol-Binding Proteins Cellular Sulfides Vascular Remodeling
Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.
Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel AB Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli, Amanda H Waterman, Michael Zimmermann, Paul M Stewart, John Wright, Mark Mon-Williams, Darren Charles Greenwood, Laura J Hardie
Jun 11, 2021
BACKGROUND: Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on...
Models of Intrauterine growth restriction and fetal programming in rabbits.
Jorge Lopez-Tello, Maria Arias-Alvarez, Antonio Gonzalez-Bulnes, Amanda N Sferuzzi-Perri
Mar 18, 2020
Intrauterine growth restriction (IUGR) affects approximately 10% of human pregnancies globally and has immediate and life-long consequences for offspring health. However, the mechanisms underlying the pathogenesis of IUGR and...
Fetal anogenital distance using ultrasound.
Ezra Aydin, Rosemary Holt, Daren Chaplin, Rebecca Hawkes, Carrie Allison, Gerald Hackett, Topun Austin, Alex Tsompanidis, Lidia Gabis, Shimrit Ilana Ziv, Simon Baron-Cohen
May 02, 2019
Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice.
Lindsey M Berends, Laura Dearden, Yi Chun L Tung, Peter Voshol, Denise S Fernandez-Twinn, Susan E Ozanne
Nov 22, 2018
AIMS: Intra-uterine growth restriction (IUGR) followed by accelerated postnatal growth is associated with an increased risk of obesity and type 2 diabetes. We aimed to determine central and peripheral insulin sensitivity in mice...
Catch-up growth developmental programming Diabetes Hypothalamus IUGR Insulin Resistance Adipose Tissue Animal Feed Animals Animals Newborn Body composition Body Weight Diabetes mellitus Type 2 Disease Models Animal Female Fetal Growth Retardation Glucose Clamp Technique Glucose Intolerance Glucose Tolerance Test Insulin Insulin Resistance Male Mice Mice Inbred C57BL obesity Signal Transduction Time Factors
Routine Third Trimester Sonogram
Several risk factors for adverse pregnancy outcomes can be identified by a routine third trimester ultrasound scan. However, there is also potential for harm, anxiety, and additional health care costs through unnecessary...
Doppler fetal growth restriction Fetal presentation large for gestational age screening Small for gestational age Stillbirth ULTRASOUND Amniotic Fluid Anxiety Biomarkers Breech Presentation False Positive Reactions Female Fetal Development Fetal Growth Retardation Fetal Macrosomia Humans Pregnancy Pregnancy Outcome Pregnancy Trimester Third Prenatal Diagnosis Risk Factors Stillbirth Ultrasonography Doppler Ultrasonography Prenatal
Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance.
Antonia Hufnagel, Denise S Fernandez-Twinn, Heather L Blackmore, Thomas J Ashmore, Robert A Heaton, Benjamin Jenkins, Albert Koulman, Iain P Hargreaves, Catherine E Aiken, Susan E Ozanne
Oct 01, 2021
Maternal obesity is a global problem that increases the risk of short- and long-term adverse outcomes for mother and child, many of which are linked to gestational diabetes mellitus. Effective treatments are essential to prevent...
The RNA landscape of the human placenta in health and disease.
Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D W Kirk, Sylvia Richardson, Gordon C S Smith, D Stephen Charnock-Jones
Jun 12, 2021
Placenta Humans Fetal Growth Retardation pre-eclampsia Follistatin-Related Proteins RNA Biopsy Gene Expression Regulation Developmental Pregnancy Female Transcriptome Datasets as Topic RNA-seq
Published by: Nature Communications
Association of birthweight centiles and early childhood development of singleton infants born from 37 weeks of gestation in Scotland
Abiodun Adanikin, Deborah A Lawlor, Jill P Pell, Scott M Nelson, Gordon CS Smith, Stamatina Iliodromiti
Nov 15, 2022
Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.
Conditions such as small for gestational age (SGA), which is defined as birthweight less than 10th percentile for gestational age can predispose to neurodevelopmental abnormalities compared to babies with normal birthweight....
A maternal serum metabolite ratio predicts fetal growth restriction at term.
Ulla Sovio, Neil Goulding, Nancy McBride, Emma Cook, Francesca Gaccioli, D Stephen Charnock-Jones, Debbie A Lawlor, Gordon CS Smith
Feb 03, 2020
Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue.
BACKGROUND: It is now widely accepted that the early-life nutritional environment is important in determining susceptibility to metabolic diseases. In particular, intra-uterine growth restriction followed by accelerated...
Adipocytes Adipose Tissue Animals Blotting Western Body Weight Diabetes mellitus Type 2 Female Fetal Development Fetal Growth Retardation Gene Expression Insulin Insulin Resistance Male Metabolic Syndrome obesity Phenotype Phosphorylation Pregnancy prenatal exposure delayed effects Proto-Oncogene Proteins c-akt Rats Rats Wistar
Endoplasmic reticulum stress disrupts placental morphogenesis
Hong Wa Yung, Myriam Hemberger, Erica D Watson, Claire E Senner, Carolyn P Jones, Randal J Kaufman, D Stephen Charnock-Jones, Graham J Burton
Aug 10, 2020
We recently reported the first evidence of placental endoplasmic reticulum (ER) stress in the pathophysiology of human intrauterine growth restriction. Here, we used a mouse model to investigate potential underlying mechanisms....
Akt IGF2 Pdk1 Endoplasmic Reticulum intrauterine growth restriction mTOR placental morphogenesis Stress Animals Cell Differentiation Disease Models Animal Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 Female Fetal Growth Retardation Glycoproteins Glycosylation Humans Mice Inbred C57BL Mice Mutant Strains Organ Size Placenta Placentation Pregnancy Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Pyruvate Dehydrogenase Acetyl-Transferring Kinase Signal Transduction TOR Serine-Threonine Kinases
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