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Results: 29
MRI visual rating scales in the diagnosis of dementia
Lorna Harper, Giorgio G Fumagalli, Frederik Barkhof, Philip Scheltens, John T O'Brien, Femke Bouwman, Emma J Burton, Jonathan D Rohrer, Nick C Fox, Gerard R Ridgway, Jonathan M Schott
Jan 29, 2016
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
Peter St George-Hyslop, Julie Qiaojin Lin, Akinori Miyashita, Emma C Phillips, Seema Qamar, Suzanne J Randle, GuoZhen Wang
Sep 05, 2018
Amyotrophic Lateral Sclerosis arginine methylation Cation-pi interactions frontotemporal dementia phase separation RNA binding proteins Amyotrophic Lateral Sclerosis biophysics Cytoplasmic Granules DNA-Binding Proteins frontotemporal dementia Frontotemporal Lobar Degeneration Humans Mutation Neurodegenerative Diseases Protein Domains Protein Processing Post-Translational RNA-Binding Protein FUS RNA-Binding Proteins Temporal Lobe
Neurophysiological signatures of Alzheimer's disease and frontotemporal lobar degeneration
Saber Sami, Nitin Williams, Laura E Hughes, Thomas E Cope, Timothy Rittman, Ian TS Coyle-Gilchrist, Richard N Henson, James B Rowe
Sep 20, 2018
The disruption of brain networks is characteristic of neurodegenerative dementias. However, it is controversial whether changes in connectivity reflect only the functional anatomy of disease, with selective vulnerability of...
Aged Alzheimer Disease Biomarkers Brain Connectome Diagnostic Techniques Neurological Female frontotemporal dementia Frontotemporal Lobar Degeneration Humans Magnetic Resonance Imaging Magnetoencephalography Male Middle Aged Nerve Net Neurodegenerative Diseases neurophysiology Phenotype Temporal Lobe
Apathy and impulsivity in frontotemporal lobar degeneration syndromes
CJ Lansdall, ITS Coyle-Gilchrist, PS Jones, P Vázquez Rodríguez, A Wilcox, E Wehmann, KM Dick, TW Robbins, JB Rowe
May 26, 2017
Apathy and impulsivity in frontotemporal lobar degeneration syndromes
Claire Lansdall, ITS Coyle-Gilchrist, Peter Simon Jones, Rodríguez P Vázquez, A Wilcox, E Wehmann, KM Dick, Trevor William Robbins, James Benedict Rowe
May 26, 2017
C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
Beatrice Costa, Claudia Manzoni, Manuel Bernal-Quiros, Demis A Kia, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Ole Andreassen, Maria Anfossi, Silvia Bagnoli, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Daniel Blackburn, Mercè Boada, Barbara Borroni, Lucy Bowns, Geir Bråthen, Amalia C Bruni, Huei-Hsin Chiang, Jordi Clarimon, Shuna Colville, Maria E Conidi, Tom E Cope, Carlos Cruchaga, Chiara Cupidi, Maria Elena Di Battista, Janine Diehl-Schmid, Monica Diez-Fairen, Oriol Dols-Icardo, Elisabetta Durante, Dušan Flisar, Francesca Frangipane, Daniela Galimberti, Maura Gallo, Maurizio Gallucci, Roberta Ghidoni, Caroline Graff, Jordan H Grafman, Murray Grossman, John Hardy, Isabel Hernández, Guy JT Holloway, Edward D Huey, Ignacio Illán-Gala, Anna Karydas, Behzad Khoshnood, Milica G Kramberger, Mark Kristiansen, Patrick A Lewis, Alberto Lleó, Gaganjit K Madhan, Raffaele Maletta, Aleš Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce Miller, Merel O Mol, Parastoo Momeni, Sonia Moreno-Grau, Chris M Morris, Benedetta Nacmias, Christer Nilsson, Valeria Novelli, Linn Öijerstedt, Alessandro Padovani, Suvankar Pal, Yasmin Panchbhaya, Pau Pastor, Borut Peterlin, Irene Piaceri, Stuart Pickering-Brown, Yolande AL Pijnenburg, Annibale A Puca, Innocenzo Rainero, Antonella Rendina, Anna MT Richardson, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Giacomina Rossi, Carola Rossmeier, James B Rowe, Elisa Rubino, Agustín Ruiz, Raquel Sanchez-Valle, Sigrid B Sando, Alexander F Santillo, Jennifer Saxon, Elio Scarpini, Maria Serpente, Nicoletta Smirne, Sandro Sorbi, EunRan Suh, Fabrizio Tagliavini, Jennifer C Thompson, John Q Trojanowski, Vivianna M Van Deerlin, Julie van der Zee, Christine Van Broeckhoven, Jeroen van Rooij, John C van Swieten, Arianna Veronesi, Emilia Vitale, Maria L Waldö, Cathy Woodward, Jennifer Yokoyama, Valentina Escott-Price, James M Polke, Raffaele Ferrari, International FTD-Genetics Consortium
Sep 10, 2020
OBJECTIVE: We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European...
Age of Onset Aged Aged 80 and over Aphasia Primary Progressive C9orf72 Protein Cohort Studies DNA Repeat Expansion Europe Female frontotemporal dementia Frontotemporal Lobar Degeneration Geography Humans Male Mediterranean Region Middle Aged principal component analysis Scandinavian and Nordic Countries Syndrome
Metabolomic changes associated with frontotemporal lobar degeneration syndromes
Alexander G. Murley, P. Simon Jones, Ian Coyle Gilchrist, Lucy Bowns, Julie Wiggins, Kamen A. Tsvetanov, James B. Rowe
Apr 10, 2021
Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis.
Janice SW Ng, Maya A Hanspal, Naunehal S Matharu, Teresa P Barros, Elin K Esbjörner, Mark R Wilson, Justin J Yerbury, Christopher M Dobson, Janet R Kumita
Sep 09, 2019
TAR DNA-binding protein 43 (TDP-43) has been identified as the major constituent of the proteinaceous inclusions that are characteristic of most forms of amyotrophic lateral sclerosis (ALS) and ubiquitin positive frontotemporal...
Amino Acid Sequence Amyotrophic Lateral Sclerosis Cell Line Tumor Cell Nucleus Cysteine Cytosol DNA-Binding Proteins Electroporation Fluoresceins Fluorescent Dyes Frontotemporal Lobar Degeneration Humans Kinetics Models Biological Optical Imaging Organometallic Compounds Protein Transport Sequence Tagged Sites Time-Lapse Imaging Transfection
Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.
Alexander G Murley, Matthew A Rouse, Ian TS Coyle-Gilchrist, P Simon Jones, Win Li, Julie Wiggins, Claire Lansdall, Patricia Vázquez Rodríguez, Alicia Wilcox, Karalyn Patterson, James B Rowe
Feb 11, 2021
OBJECTIVE: To test the hypothesis that in syndromes associated with frontotemporal lobar degeneration, behavioural impairment predicts loss of functional independence and motor clinical features predict mortality, irrespective...
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
Tetsuro Murakami, Seema Qamar, Julie Qiaojin Lin, Gabriele S Kaminski Schierle, Eric Rees, Akinori Miyashita, Ana R Costa, Roger B Dodd, Fiona TS Chan, Claire H Michel, Deborah Kronenberg-Versteeg, Yi Li, Seung-Pil Yang, Yosuke Wakutani, William Meadows, Rodylyn Rose Ferry, Liang Dong, Gian Gaetano Tartaglia, Giorgio Favrin, Wen-Lang Lin, Dennis W Dickson, Mei Zhen, David Ron, Gerold Schmitt-Ulms, Paul E Fraser, Neil A Shneider, Christine Holt, Michele Vendruscolo, Clemens F Kaminski, Peter St George-Hyslop
Oct 22, 2015
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.
Alexander G Murley, Kamen A Tsvetanov, Matthew A Rouse, P Simon Jones, Katrine Sværke, Win Li, Adrian Carpenter, James B Rowe
Nov 19, 2021
There is an urgent need for a better understanding of the pathophysiology of cognitive impairment in syndromes associated with frontotemporal lobar degeneration. Here, we used magnetic resonance spectroscopy to quantify...
Behavioral variant frontotemporal dementia Corticobasal syndrome Frontotemporal Lobar Degeneration Glutamate progressive supranuclear palsy spectroscopy Aged Aspartic Acid Behavior Cognition Executive Function Female Frontotemporal Lobar Degeneration Glutamates Humans Male Middle Aged Prefrontal Cortex Primary visual cortex Proton Magnetic Resonance Spectroscopy Temporal Lobe
Metabolomic changes associated with frontotemporal lobar degeneration syndromes.
Alexander G Murley, P Simon Jones, Ian Coyle Gilchrist, Lucy Bowns, Julie Wiggins, Kamen A Tsvetanov, James B Rowe
Apr 06, 2020
Metabolomic changes associated with frontotemporal lobar degeneration syndromes
Alexander G. Murley, P. Simon Jones, Ian Coyle Gilchrist, Lucy Bowns, Julie Wiggins, Kamen A. Tsvetanov, James B. Rowe
Jul 14, 2020
Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes
Alexander G Murley, Ian Coyle-Gilchrist, Matthew Rouse, P Simon Jones, Win Li, Julie Wiggins, Claire Lansdall, Patricia Vázquez Rodríguez, Alicia Wilcox, Kamen A Tsvetanov, Karalyn Patterson, Matthew A Lambon Ralph, James B Rowe
Mar 10, 2020
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.
Alexander G Murley, Matthew A Rouse, P Simon Jones, Rong Ye, Frank H Hezemans, Claire O'Callaghan, Polytimi Frangou, Zoe Kourtzi, Catarina Rua, T Adrian Carpenter, Christopher T Rodgers, James B Rowe
Jul 28, 2020
GABA frontotemporal dementia Glutamate Impulsivity progressive supranuclear palsy Aged Aged 80 and over Female Frontotemporal Lobar Degeneration Glutamates Humans INHIBITION Psychological Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Neuropsychological Tests Neurotransmitter Agents Reaction Time Supranuclear Palsy Progressive Visual Cortex gamma-Aminobutyric Acid
Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia.
Alberto Benussi, Antonella Alberici, Kiran Samra, Lucy L Russell, Caroline V Greaves, Martina Bocchetta, Simon Ducharme, Elizabeth Finger, Giorgio Fumagalli, Daniela Galimberti, Lize C Jiskoot, Isabelle Le Ber, Mario Masellis, Benedetta Nacmias, James B Rowe, Raquel Sanchez-Valle, Harro Seelaar, Matthis Synofzik, GENFI Consortium, Jonathan D Rohrer, Barbara Borroni
Dec 24, 2021
FRONTotemporal dementia Incidence European Research Study-FRONTIERS
Barbara Borroni, Caroline Graff, Orla Hardiman, Albert C Ludolph, Fermin Moreno, Markus Otto, Marco Piccininni, Anne M Remes, James B Rowe, Harro Seelaar, Elka Stefanova, Latchezar Traykov, Giancarlo Logroscino, FRONTIERS
Sep 16, 2021
INTRODUCTION: The incidence of Frontotemporal Lobar Degeneration (FTLD)-related disorders and their characteristics are not well known. The "FRONTotemporal dementia Incidence European Research Study" (FRONTIERS) is designed to...
FRONTotemporal dementia Incidence European Research Study—FRONTIERS
Barbara Borroni, Caroline Graff, Orla Hardiman, Albert C. Ludolph, Fermin Moreno, Markus Otto, Marco Piccininni, Anne M Remes, James B Rowe, Harro Seelaar, Elka Stefanova, Latchezar Traykov, Giancarlo Logroscino, FRONTIERS
Aug 02, 2021
Abstract: Introduction: The incidence of Frontotemporal Lobar Degeneration (FTLD)–related disorders and their characteristics are not well known. The “FRONTotemporal dementia Incidence European Research Study” (FRONTIERS) is...
review article Review articles EPIDEMIOLOGY frontotemporal dementia Frontotemporal Lobar Degeneration Incidence Rare Diseases Registry
Published by: Alzheimer's & Dementia
White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes.
Claire J Lansdall, Ian TS Coyle-Gilchrist, P Simon Jones, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Katrina M Dick, Trevor W Robbins, James B Rowe
Mar 05, 2018
OBJECTIVE: To identify the white matter correlates of apathy and impulsivity in the major syndromes associated with frontotemporal lobar degeneration, using diffusion-weighted imaging and data from the PiPPIN (Pick's Disease and...
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.
Seema Qamar, GuoZhen Wang, Suzanne J Randle, Francesco Simone Ruggeri, Juan A Varela, Julie Qiaojin Lin, Emma C Phillips, Akinori Miyashita, Declan Williams, Florian Ströhl, William Meadows, Rodylyn Ferry, Victoria J Dardov, Gian G Tartaglia, Lindsay A Farrer, Gabriele S Kaminski Schierle, Clemens F Kaminski, Christine E Holt, Paul E Fraser, Gerold Schmitt-Ulms, David Klenerman, Tuomas Knowles, Michele Vendruscolo, Peter St George-Hyslop
Sep 05, 2018
Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report...
AFM-IR arginine methylation cation-π citrullination frontotemporal dementia membraneless organelle neuronal ribonucleoprotein granule phase separation phase-sensitive fluorescent dyes synaptic new protein synthesis Amyotrophic Lateral Sclerosis Animals Arginine cations DNA Methylation frontotemporal dementia Frontotemporal Lobar Degeneration Humans Microscopy Atomic Force Microscopy Fluorescence Molecular Chaperones Protein Binding Protein Domains Protein Processing Post-Translational Protein Structure Secondary RNA-Binding Protein FUS Tyrosine Xenopus laevis
Limbic-predominant age-related TDP-43 encephalopathy (LATE)
Peter T Nelson, Dennis W Dickson, John Q Trojanowski, Clifford R Jack, Patricia A Boyle, Konstantinos Arfanakis, Rosa Rademakers, Irina Alafuzoff, Johannes Attems, Carol Brayne, Ian TS Coyle-Gilchrist, Helena C Chui, David W Fardo, Margaret E Flanagan, Glenda Halliday, Suvi RK Hokkanen, Sally Hunter, Gregory A Jicha, Yuriko Katsumata, Claudia H Kawas, C Dirk Keene, Gabor G Kovacs, Walter A Kukull, Allan I Levey, Nazanin Makkinejad, Thomas J Montine, Shigeo Murayama, Melissa E Murray, Sukriti Nag, Robert A Rissman, William W Seeley, Reisa A Sperling, Charles L White, Lei Yu, Julie A Schneider
Mar 18, 2019
Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes.
Ian TS Coyle-Gilchrist, Katrina M Dick, Karalyn Patterson, Patricia Vázquez Rodríquez, Eileen Wehmann, Alicia Wilcox, Claire J Lansdall, Kate E Dawson, Julie Wiggins, Simon Mead, Carol Brayne, James B Rowe
Mar 15, 2016
Prognostic importance of apathy in syndromes associated with frontotemporal lobar degeneration.
Claire J Lansdall, Ian TS Coyle-Gilchrist, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Trevor W Robbins, James B Rowe
Jan 17, 2019
Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.
Michael Fernandopulle, GuoZhen Wang, Jonathon Nixon-Abell, Seema Qamar, Varun Balaji, Ryuta Morihara, Peter H St George-Hyslop
Jul 08, 2019
ANXA11 Amyotrophic Lateral Sclerosis FUS TDP-43 biological condensates fronto-temporal dementia gelation Hydrogels local RNA translation neuronal transport granules phase separation Stress granules Amyotrophic Lateral Sclerosis Annexins Biological Transport DNA-Binding Proteins Frontotemporal Lobar Degeneration Humans Intracellular Membranes Mutation Missense Neurodegenerative Diseases Neurons Protein Processing Post-Translational RNA-Binding Protein FUS Temporal Lobe
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